Table 2 Echocardiography findings in patients with MYBPC3 and MYH7 gene mutation
From: Genetic determinants of clinical phenotype in hypertrophic cardiomyopathy
| Â | Overall | MYBPC3 | MYH7 | p value |
|---|---|---|---|---|
PLW thickness (mm) | 10.6 ± 2.0 | 10.6 ± 2.1 | 10.8 ± 1.7 | 0.776 |
IVS thickness (mm) | 21.5 ± 7.1 | 21.5 ± 7.0 | 21.6 ± 7.9 | 0.982 |
LA volume (ml) | 115.6 ± 56 | 111.7 ± 83.9 | 130.3 ± 87.2 | 0.518 |
LV end-diastolic volume (ml) | 108.9 ± 49.7 | 110.8 ± 52.2 | 92.7 ± 7.0 | 0.560 |
LV end-systolic volume (ml) | 51.6 ± 35.6 | 52.6 ± 37.4 | 44.0 ± 19.0 | 0.700 |
LV ejection fraction (%) | 55.3 ± 7.8 | 55.6 ± 8.2 | 54.1 ± 6.3 | 0.594 |
LV mass (g) | 301.4 ± 114.0 | 306.0 ± 115.2 | 261.0 ± 115.4 | 0.527 |
LV mass index (g/m2) | 155.9 ± 52.3 | 159.0 ± 53.1 | 129.5 ± 43.1 | 0.364 |
Relative wall thickness | 0.43 ± 0.10 | 0.44 ± 0.10 | 0.34 ± 0.02 | 0.103 |
LV outflow pressure gradient (mmHg) | 8.2 ± 11.1 | 6.0 ± 2.5 | 16.1 ± 22.7 | 0.252 |
E/e′ ratio | 9.7 ± 4.5 | 8.8 ± 3.3 | 13.9 ± 6.9 | 0.079* |
TAPSE (mm) | 21.4 ± 4.8 | 21.0 ± 4.4 | 22.5 ± 6.0 | 0.363 |
Systolic anterior motion, n (%) | 10 (15.9%) | 5 (10.4%) | 5 (33.3%) | 0.025* |
Papillary muscle abnormalities, n (%) | 4 (6.3%) | 4 (8.3%) | – | 0.261 |
Mitral leaflet abnormalities, n (%) | 15 (23.8%) | 9 (18.8%) | 6 (40.0%) | 0.039* |
Calcification of mitral annulus, n (%) | 3 (4.8%) | – | 3 (20.0%) | 0.001* |