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Table 2 Association of serum lactate levels and clearance with 30-day mortality in unadjusted and adjusted analyses

From: Association between serum lactate levels and mortality in patients with cardiogenic shock receiving mechanical circulatory support: a multicenter retrospective cohort study

 

Unadjusted

Adjusted (model 1)a,d

Adjusted (model 2)b,d

Adjusted (model 3)c,d

 

OR

95% CI

P

OR

95% CI

P

OR

95% CI

P

OR

95% CI

P

Lactate, baseline

1.15

1.00–1.39

0.04

1.13

0.98–1.37

0.09

1.19

1.01–1.48

0.03

1.21

1.01–1.55

0.03

Lactate, 1 h

1.13

1.00–1.33

0.05

1.11

0.97–1.32

0.14

1.21

1.02–1.50

0.02

1.29

1.07–1.73

0.005

Lactate, 6 h

1.18

1.03–1.47

0.01

1.16

1.01–1.45

0.03

1.27

1.07–1.64

0.004

1.34

1.10–1.95

0.01

Lactate, 12 h

1.27

1.05–1.76

0.005

1.25

1.04–1.74

0.01

1.46

1.13–2.22

0.001

1.62

1.19–3.03

< 0.001

Lactate, 24 h

1.76

1.13–4.33

0.001

1.63

1.11–3.88

0.001

2.37

1.24–6.90

< 0.001

5.86

1.53–67.86

< 0.001

Overall lactatee

1.27

1.06–1.70

0.03

1.26

1.04–1.71

0.01

1.54

1.16–2.50

< 0.001

1.73

1.20–3.48

< 0.001

Clearance, 1hf,g

1.00

0.98–1.01

0.60

1.00

0.98–1.01

0.81

0.99

0.97–1.01

0.31

0.99

0.97–1.01

0.10

Clearance, 6hf,g

0.98

0.97–0.99

0.01

0.98

0.97–0.99

0.01

0.97

0.95–0.99

0.002

0.97

0.94–0.99

0.002

Clearance, 12hf,g

0.98

0.96–0.99

0.006

0.98

0.96–0.99

0.005

0.97

0.94–0.99

< 0.001

0.97

0.93–0.99

< 0.001

Clearance, 24hf,g

0.95

0.91–0.98

< 0.001

0.95

0.90–0.99

< 0.001

0.94

0.87–0.98

< 0.001

0.97

0.78–0.98

< 0.001

  1. CI, confidence interval; OR, odds ratio
  2. aModel 1: adjusted by type of device (ECMO or Impella), pre-device cardiac arrest, center
  3. bModel 2: adjusted by age, type of device (ECMO or Impella), shock to support time, center
  4. cModel 3: adjusted by SOFA, SAPS 3, center
  5. dThere was no evidence of multicollinearity as assessed by the variance inflation test
  6. eOverall lactate represents the mean serum lactate effect (1 h, 6 h, 12 h, 24 h) on 30-day mortality
  7. fClearance was calculated as the following: [(lactate at time point of interest – initial lactate)/initial lactate*100]
  8. gAll lactate clearance models were adjusted for initial lactate levels