Table 3 Linear regressions comparing aortic stenosis severity with extracellular matrix remodeling
From: Atrial matrix remodeling in atrial fibrillation patients with aortic stenosis
Variable | B coefficient | 95% CI | p value |
|---|---|---|---|
AoMaxG | |||
Cardiomyocyte Area | 0.089 | [− 0.069 to 0.248] | 0.250 |
Fibrosis | − 8.431 | [− 184.602 to 167.741] | 0.920 |
COL1A1 | − 493,530.998 | [− 929322.424 to − 57739] | 0.029 |
COL3A1 | − 106,482.445 | [− 240598.920 to 27,634.031] | 0.110 |
COL1A1/3A1 Ratio | − 88.731 | [− 165.756 to − 11.706] | 0.027 |
MMP2 | − 27,782.426 | [− 170179.428 to 114,614.396] | 0.680 |
MMP9 | − 595,526.093 | [− 1429715.173 to 238,662.988] | 0.147 |
MMP16 | 1,691,707.088 | [− 3869174.848 to 7,252,589.024] | 0.523 |
TIMP1 | 14,457.016 | [− 7526.012 to 36,440.044] | 0.179 |
TIMP2 | 5262.861 | [− 85597.990 to 96,123.712] | 0.902 |
TIMP4 | − 47,199.665 | [− 445150.640 to 350,751.311 | 0.799 |
MMP2/TIMP1 Ratio | − 79.725 | [− 159.870 to 0.419] | 0.051 |
MMP2/TIMP2 Ratio | − 30.903 | [− 94.861 to 33.056] | 0.316 |
MMP9/TIMP1 Ratio | − 330.433 | [− 732.257 to 71.391] | 0.099 |
MMP2/TIMP4 Ratio | − 0.345 | [− 2.205 to 1.516] | 0.691 |
MMP16/TIMP4 Ratio | 7.394 | [− 69.324 to 84.111] | 0.836 |
Serum TIMP1 | − 0.004 | [− 0.006 to − 0.001] | 0.015 |
Serum TIMP2 | 0.028 | [− 0.235 to 0.292] | 0.822 |
AoMG | |||
Cardiomyocyte Area | 0.038 | [− 0.059 to 0.135] | 0.421 |
Fibrosis | 9.331 | [− 93.022 to 111.684] | 0.850 |
COL1A1 | − 248,924.745 | [− 492536.116 to − 5313.373] | 0.046 |
COL3A1 | − 55,243.442 | [− 128681.989 to 18,195.105] | 0.128 |
COL1A1/3A1 Ratio | − 44.441 | [− 87.659 to − 1.224] | 0.045 |
MMP2 | − 8256.311 | [− 85857.707 to 69,345.085] | 0.822 |
MMP9 | − 273,834.048 | [− 737776.442 to 190,108.346] | 0.225 |
MMP16 | 1,163,548.388 | [− 1821928.808 to 4,149,025.584] | 0.415 |
TIMP1 | 9237.603 | [− 2320.881 to 20,796.086] | 0.108 |
TIMP2 | 8692.535 | [− 40342.265 to 57,727.334] | 0.708 |
TIMP4 | − 20,738.463 | [− 241638.087 to 200,161.161] | 0.840 |
MMP2/TIMP1 Ratio | − 44.416 | [− 87.457 to − 1.375] | 0.044 |
MMP2/TIMP2 Ratio | − 20.424 | [− 54.401 to 13.554] | 0.217 |
MMP9/TIMP1 Ratio | − 157.431 | [− 381.331 to 66.470] | 0.153 |
MMP2/TIMP4 Ratio | − 0.215 | [− 1.244 to 0.815] | 0.655 |
MMP16/TIMP4 Ratio | 0.796 | [− 41.824 to 43.416] | 0.968 |
Serum TIMP1 | − 0.002 | [− 0.004 to − 0.0002] | 0.031 |
Serum TIMP2 | 0.002 | [− 0.166 to 0.169] | 0.983 |
AVA | |||
Cardiomyocyte Area | − 0.001 | [− 0.002 to − 2.6E−5] | 0.043 |
Fibrosis | − 0.628 | [− 1.749 to 0.493] | 0.251 |
COL1A1 | 4045.908 | [564.094 to 7527.721] | 0.026 |
COL3A1 | 999.124 | [− 42.261 to 2040.509] | 0.059 |
COL1A1/3A1 Ratio | 0.684 | [0.050 to 1.319] | 0.037 |
MMP2 | 31.793 | [− 1153.160 to 1216.745] | 0.954 |
MMP9 | 2748.383 | [− 4536.323 to 10,033.089] | 0.427 |
MMP16 | − 16,518.724 | [− 64280.280 to 31,242.833] | 0.466 |
TIMP1 | − 65.689 | [− 255.398 to 124.020] | 0.465 |
TIMP2 | − 118.969 | [− 861.135 to 623.197] | 0.733 |
TIMP4 | − 1791.725 | [− 4921.305 to 1337.855] | 0.231 |
MMP2/TIMP1 Ratio | 0.089 | [− 0.678 to 0.855] | 0.806 |
MMP2/TIMP2 Ratio | 0.309 | [− 0.225 to 0.843] | 0.231 |
MMP9/TIMP1 Ratio | 1.551 | [− 2.011 to 5.114] | 0.361 |
MMP2/TIMP4 Ratio | 0.009 | [− 0.006 to 0.023] | 0.200 |
MMP16/TIMP4 Ratio | 0.281 | [− 0.326 to 0.889] | 0.326 |
Serum TIMP1 | 8.697E−6 | [2.4E−5 to 4.1E−5] | 0.577 |
Serum TIMP2 | − 0.001 | [− 0.004 to 0.001] | 0.303 |