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Table 2 Diagnostic accuracy of hs-cTnI for AMI in patients according to sex, age and eGFR category

From: High-sensitive cardiac troponin for the diagnosis of acute myocardial infarction in different chronic kidney disease stages

  AMI (n, %) Sensitivity (%, 95% CI) Specificity (%, 95% CI) AUC (95% CI) P value
All patients (n = 3295) 2758 (83.7)     
Cut-off = 1.15 ng mL−1   82.5 (81.0, 83.9) 95.4 (91.7, 97.8) 0.924 (0.914, 0.933) < 0.001
(a) Male patients younger than 60 years with eGFR ≥ 60 mL min−1 (1.73 m2)−1 (n = 896) 798 (89.1)     
Cut-off = 0.24 ng mL−1   91.6 (89.5, 93.4) 100.0 (96.3, 100.0) 0.984 (0.973, 0.991) < 0.001
(b) Male patients aged 60 or above with eGFR ≥ 60 mL min−1 (1.73 m2)−1 (n = 1088) 1028 (94.5)     
Cut-off = 0.31 ng mL−1   90.9 (88.9, 92.6) 100.0 (95.9, 100.0) 0.962 (0.949, 0.973) < 0.001
(c) Female patients younger than 60 years with eGFR ≥ 60 mL min−1 (1.73 m2)−1 (n = 154) 81 (52.6)     
Cut-off = 0.27 ng mL−1   93.2 (84.9, 97.8) 100.0 (95.5, 100.0) 0.979 (0.941, 0.995) < 0.001
(d) Female patients aged 60 or above with GFR ≥ 60 mL min−1 (1.73 m2)−1 (n = 396) 357 (90.2)     
Cut-off = 0.27 ng mL−1   91.0 (87.5, 93.8) 100.0 (93.0, 100.0) 0.946 (0.918, 0.966) < 0.001
(e) Male patients younger than 60 years with 30 ≤ eGFR< 60 mL min−1 (1.73 m2)−1 (n = 76) 56 (73.7)     
Cut-off = 0.72 ng mL−1   81.4 (66.6, 91.6) 100.0 (89.4, 100.0) 0.869 (0.772, 0.936) < 0.001
(f) Male patients aged 60 or above with 30 ≤ eGFR< 60 mL min−1 (1.73 m2)−1 (n = 330) 267 (80.9)     
Cut-off = 0.50 ng mL−1   89.5 (85.2, 92.9) 100.0 (94.3, 100.0) 0.959 (0.932, 0.978) < 0.001
(g) Female patients aged 60 or above with 30 ≤ eGFR< 60 mL min−1 (1.73 m2)1 (n = 178) 128 (71.9)     
Cut-off = 0.59 ng mL−1   91.4 (85.1, 95.6) 100.0 (92.9, 100.0) 0.952 (0.910, 0.979) < 0.001
(h) Male patients aged 60 or above with 15 ≤ eGFR< 30 mL min−1 (1.73 m2)−1 (n = 89) 51 (57.3)     
Cut-off = 2.61 ng mL−1   80.4 (66.9, 90.2) 92.1 (78.6, 98.3) 0.907 (0.827, 0.958) < 0.001
(i) Female patients aged 60 or above with 15 ≤ eGFR< 30 mL min−1 (1.73 m2)−1 (n = 56) 28 (50.0)     
Cut-off = 1.90 ng mL−1   89.3 (71.8, 97.7) 100.0 (87.7, 100.0) 0.943 (0.846, 0.987) < 0.001
  1. AMI acute myocardial infarction, eGFR estimated glomerular filtration rate, hs-cTnI high-sensitive cardiac troponin I, CI confidence interval, AUC area under the curve