Table 2 Diagnostic accuracy of hs-cTnI for AMI in patients according to sex, age and eGFR category

All patients (n = 3295)

2758 (83.7)

Cut-off = 1.15 ng mL⁻¹

82.5 (81.0, 83.9)

95.4 (91.7, 97.8)

0.924 (0.914, 0.933)

< 0.001

(a) Male patients younger than 60 years with eGFR ≥ 60 mL min⁻¹ (1.73 m²)⁻¹ (n = 896)

798 (89.1)

Cut-off = 0.24 ng mL⁻¹

91.6 (89.5, 93.4)

100.0 (96.3, 100.0)

0.984 (0.973, 0.991)

< 0.001

(b) Male patients aged 60 or above with eGFR ≥ 60 mL min⁻¹ (1.73 m²)⁻¹ (n = 1088)

1028 (94.5)

Cut-off = 0.31 ng mL⁻¹

90.9 (88.9, 92.6)

100.0 (95.9, 100.0)

0.962 (0.949, 0.973)

< 0.001

(c) Female patients younger than 60 years with eGFR ≥ 60 mL min⁻¹ (1.73 m²)⁻¹ (n = 154)

81 (52.6)

Cut-off = 0.27 ng mL⁻¹

93.2 (84.9, 97.8)

100.0 (95.5, 100.0)

0.979 (0.941, 0.995)

< 0.001

(d) Female patients aged 60 or above with GFR ≥ 60 mL min⁻¹ (1.73 m²)⁻¹ (n = 396)

357 (90.2)

Cut-off = 0.27 ng mL⁻¹

91.0 (87.5, 93.8)

100.0 (93.0, 100.0)

0.946 (0.918, 0.966)

< 0.001

(e) Male patients younger than 60 years with 30 ≤ eGFR< 60 mL min⁻¹ (1.73 m²)⁻¹ (n = 76)

56 (73.7)

Cut-off = 0.72 ng mL⁻¹

81.4 (66.6, 91.6)

100.0 (89.4, 100.0)

0.869 (0.772, 0.936)

< 0.001

(f) Male patients aged 60 or above with 30 ≤ eGFR< 60 mL min⁻¹ (1.73 m²)⁻¹ (n = 330)

267 (80.9)

Cut-off = 0.50 ng mL⁻¹

89.5 (85.2, 92.9)

100.0 (94.3, 100.0)

0.959 (0.932, 0.978)

< 0.001

(g) Female patients aged 60 or above with 30 ≤ eGFR< 60 mL min⁻¹ (1.73 m²)⁻1 (n = 178)

128 (71.9)

Cut-off = 0.59 ng mL⁻¹

91.4 (85.1, 95.6)

100.0 (92.9, 100.0)

0.952 (0.910, 0.979)

< 0.001

(h) Male patients aged 60 or above with 15 ≤ eGFR< 30 mL min⁻¹ (1.73 m²)⁻¹ (n = 89)

51 (57.3)

Cut-off = 2.61 ng mL⁻¹

80.4 (66.9, 90.2)

92.1 (78.6, 98.3)

0.907 (0.827, 0.958)

< 0.001

(i) Female patients aged 60 or above with 15 ≤ eGFR< 30 mL min⁻¹ (1.73 m²)⁻¹ (n = 56)

28 (50.0)

Cut-off = 1.90 ng mL⁻¹

89.3 (71.8, 97.7)

100.0 (87.7, 100.0)

0.943 (0.846, 0.987)

< 0.001