BMC Cardiovascular Disorders

Table 1 Results from two-sample MR analysis using 3 genetic instruments of GDF-15

From: The impact of growth differentiation factor 15 on the risk of cardiovascular diseases: two-sample Mendelian randomization study

Outcome	IVW			Weighted median			MR-Egger
Outcome	Estimate	SE	P value	Estimate	SE	P value	Estimate	SE	P value	Intercept	P value
CES	0.091	0.043	0.035	0.111	0.053	0.036	0.154	0.150	0.304	− 0.017	0.660
AIS	0.024	0.022	0.268	0.022	0.027	0.409	0.104	0.077	0.175	− 0.021	0.279
LAS	− 0.007	0.055	0.898	− 0.013	0.062	0.829	− 0.033	0.189	0.862	0.007	0.886
SVS	− 0.037	0.051	0.464	− 0.037	0.057	0.523	0.030	0.177	0.86	− 0.018	0.689
AF	0.031	0.016	0.043	0.032	0.018	0.078	0.024	0.054	0.661	0.002	0.884
HF	− 0.008	0.018	0.660	0.012	0.023	0.589	0.002	0.072	0.973	− 0.003	0.881
NICM	0.117	0.072	0.102	0.106	0.084	0.204	0.207	0.249	0.406	− 0.024	0.708
CAD	− 0.065	0.026	0.013	− 0.062	0.029	0.032	− 0.010	0.101	0.921	− 0.015	0.569
MI	− 0.063	0.024	0.009	− 0.063	0.028	0.024	− 0.097	0.084	0.249	0.009	0.671

Data are reported as OR and 95% CI
SE Std error, AIS any ischemic stroke, CES cardioembolic stroke, LAS large-artery atherosclerotic stroke, SVS small vessel stroke, AF atrial fibrillation, HF heart failure, NICM nonischemic cardiomyopathy, CAD coronary artery disease, MI myocardial infarction

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ISSN: 1471-2261

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