Fig. 6

miR-130a-5p targets HMGB2 to downregulate the NF-κB axis, mitigating inflammatory injury induced by MIRI. a Western blot analysis was applied to assess the p65 and IκBα protein levels and phosphorylation in myocardial tissues in MIRI mice, n = 4. b ELISA kits were utilized to determine the serum levels of TNF-α, IL-6 and IL-1β, n = 10. The images of a shown are cropped. One-way ANOVA and Tukey’s multiple comparisons test were applied to determine statistical significance. **p < 0.01; ^##p < 0.01; ^&&p < 0.01. miR microRNA, HMGB high mobility group box, NF-κB nuclear factor kappa-B, MIRI myocardial ischemia reperfusion injury, IκB inhibitor of κB, ELISA enzyme-linked immunosorbent assay, TNF-α tumor necrosis factor-α, IL interleukin