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Fig. 3 | BMC Cardiovascular Disorders

Fig. 3

From: microRNA-130a-5p suppresses myocardial ischemia reperfusion injury by downregulating the HMGB2/NF-κB axis

Fig. 3

Overexpressed miR-130a-5p alleviates MIRI-induced oxidative stress and mitochondrial disorder in mice. a Serum levels of LDH, MDA and SOD measured using kits, n = 10. b MMP, ATP, ROS and Ca2+ expression were tested with kits, n = 4. c Western blot analysis showed that the elevated protein levels of Cyt-c and AIF in MIRI mice were discouraged by miR-130a-5p overexpression, n = 4. The images of c shown are cropped. One-way ANOVA and Tukey’s multiple comparisons test were applied to determine the statistical significance. **p < 0.01; ##p < 0.01. miR mircoRNA, MIRI myocardial ischemia reperfusion injury, LDH lactate dehydrogenase, MDA malondialdehyde, SOD superoxide dismutase, MMP mitochondrial membrane potential, ATP adenosine triphosphate, ROS reactive oxygen species, Cyt-c Cytochrome C, AIF apoptosis inducing factor, ANOVA analysis of variance

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