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Table 3 Within group and between group change between pre vs. Active and pre vs. post intervention period for the both intervention and control

From: Thrombolysis implementation intervention and clinical outcome: a secondary analysis of a cluster randomized trial

 

Within Group Change

Between Group Change

Intervention

Control

Intervention vs. Control

Number, n (%)

OR (95% CI)

p-value

Number, n (%)

OR (95% CI)

p-value

OR (95% CI)

p-value

Excellent Outcome (Three month post treatment mRS 0–2)

 Pre-intervention period

107 (47%)

Reference

Reference

66 (32%)

Reference

Reference

Reference

Reference

 Active intervention period

106 (45%)

0.97 (0.62–1.51)

0.878

74 (39%)

1.15 (0.60–1.51)

0.834

0.98 (0.54–1.92)

0.966

 Post intervention period

72 (44%)

0.96 (0.56–1.65)

0.892

57 (36%)

1.07 (0.59–1.59)

0.906

0.99 (0.48–2.05)

0.983

Poor Outcome (Three month post treatment mRS 5–6)

 Pre-intervention period

37 (16%)

Reference

Reference

44 (21%)

Reference

Reference

Reference

Reference

 Active intervention period

34 (14%)

0.84 (0.47–1.51)

0.568

29 (15%)

0.78 (0.43–1.40)

0.397

1.09 (0.48–2.49)

0.843

 Post intervention period

24 (15%)

0.43 (0.19–0.95)

0.047

22 (14%)

0.58 (0.31–1.08)

0.087

0.74 (0.27–2.03)

0.559

PH (Post treatment)

 Pre-intervention period

21 (7.4%)

Reference

Reference

22 (7%)

Reference

Reference

Reference

Reference

 Active intervention period

9 (3.2%)

0.51 (0.22–1.18)

0.115

16 (6.2%)

0.95 (0.47–1.90)

0.880

0.54 (0.18–1.60)

0.265

 Post intervention period

10 (4.5%)

0.82 (0.35–1.95)

0.880

12 (6%)

0.90 (0.42–1.91)

0.780

0.92 (0.29–2.87)

0.884

  1. Mixed effects logistic mixed model was used
  2. Models were controlled for baseline thrombolysis rate, pre-morbid modified Rankin Score (mRS) and baseline National Institute of Health Stroke Scale (NIHSS)
  3. A p-value < 0.05 was considered as significant
  4. Within Group Change: It shows only the change from pre- to active intervention period and pre- to post intervention period for both the intervention and control arm separately
  5. Between Group Change: It shows the difference between the within group changes of the intervention and control arm for both the active and post intervention period separately