Skip to main content

Table 1 Summary of the main characteristics of included studies

From: Intermittent hypoxia reduces infarct size in rats with acute myocardial infarction: a systematic review and meta-analysis

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19
Yuan 2017 [4] SD M 330–350 g 5000 m altitude 6 h/day 28 days G 30 120 sodium pentobarbital IR/VR Means±SD 4 12.8 2.0 4 38.4 5
Li 2016 [24] SD M 220 ±? g 5000 m altitude 6 h/day 28 days G 30 120 sodium pentobarbital IR/VR Means±SD 6 27.3 5.9 6 48.3 7.5
Kasparova 2015 [3] W M 300–380 g Normobaric FiO2 10% 8 h/day 21 days LAD 20 180 Sodium pentobarbital IR/AAR Means±SE 10 46.4 4.2 10 62.7 2.7
Meng 2014 [25] W M 150–180 g 5000 m altitude 6 h/day 42 days LAD 30 240 25% ethylurethanm solution IR/AAR Means±SE 7 12.5 1.6 7 30.9 6.8
Ma 2014 [26] SD M neonate 3000 m altitude 5 h/day 42 days G 30 120 sodium pentobarbital IR/VR Means±SE 6 26.7 0.4 6 48.6 2.2
Gao 2014 [27] SD M 100–130 g 5000 m altitude 4 h/day 28 days G 30 120 sodium pentobarbital IR/AAR Means±SE 5 22.58 3 5 35.9 4.1
Manukhina 2013 [28] W M 250–280 g Normobaric FiO2 9.5–10% 4 min/cycle 5–8 cycles/day 20 days LAD 30 120 urethane IR/AAR Means±SE 10 17.5 2.6 9 30.6 5.1
Ramond 2013a [16] W M 250–350 g Normobaric FiO2 5% 40s/min 8 h/d 14 days G 30 120 sodium pentobarbital IR/VR Means±SE 7 36.0 2.8 7 21.8 3.1
Ramond 2013b [16] W M 250–350 g Normobaric FiO2 5% 40s/min 8 h/d 14 days G 30 120 sodium pentobarbital IR/VR Means±SE 8 40.3 3.5 8 29.4 3.7
Milano 2011 [17] SD M 251 ± 2 g Normobaric FiO2 10% 23 h/day 15 days LAD 30 180 sodium pentobarbital IR/AAR Means±SE 7 68.5 2.4 7 46.5 4.4
Wang 2011 [29] SD M 100–120 g 5000 m altitude 4 h/day 28 days G 30 120 pentobarbital sodium IR/AAR Means±SE 5 20.5 5.3 5 42.1 3.8
Belaidi 2008 [30] W M 330–350 g Normobaric FiO2 10% 4 h/day 1 day G 30 120 pentobarbital sodium IR/VR Means±SE 8 15.9 5.6 8 33.8 5
Yeung 2007a [31] SD M 290–320 g Normobaric FiO2 10% 6 h/day 3 days LCA 30 120 decapitated IR/AAR Means±SE 6 32.7 1.2 6 35.1 1.8
Yeung 2007b [31] SD M 290–320 g Normobaric FiO2 10% 6 h/day 7 days LCA 30 120 decapitated IR/AAR Means±SE 6 26.5 0.7 6 34.8 1.1
Yeung 2007c [31] SD M 290–320 g Normobaric FiO2 10% 6 h/day 14 days LCA 30 120 decapitated IR/AAR Means±SE 6 31.71 1.0 6 37.7 2.0
Ravingerová 2007 [32] W M 250–280 g 7000 m altitude 8 h/day 5 days/week 25–30 days LAD 20 180 sodium pentobarbiton IR/AAR Means±SE 8 51.8 4.4 8 64.9 5.1
Kolár 2007 [33] W M 250–280 g 7000 m altitude 8 h/day 24–30 days LAD 20 180 sodium pentobarbital IR/AAR Means±SE 8 27.7 4.9 8 56.7 4.5
Béguin 2007 [34] W M 330–380 g 5000 m altitude 4 h/d 1 day G 30 120 sodium pentobarbital IR/VR Means±SE 8 22.2 2.4 8 33.8 2.6
Zhu 2006 [35] SD M 100–130 g 5000 m altitude 6 h/day 42 days G 30 120 sodium pentobarbital IR/VR (LV area) Means±SE 7 24 1.9 7 42.1 2.1
Kolár 2005 [36] W M 5–6 weeks 7000 m altitude 8 h/day 35–42 days LAD 20 180 sodium pentobarbiton IR/AAR Means±SE 7 43.2 3.3 7 59.2 4.4
Béguin 2005 [37] W M 330–380 g Normobaric FiO2 10% 40s/min 4 h/d 1d G 30 120 sodium pentobarbiton IR/VR (LV area) Means±SE 11 21.8 3.1 9 33.5 2.5
Joyeux-Faure 2005 [38] W M 220–240 g Normobaric FiO2 5% 40s/min 8 h/d 35 days G 30 120 sodium pentobarbiton IR/VR Means±SE 9 46.9 3.6 9 26.1 2.8
Neckár 2005a [39] W M 250–280 g 7000 m altitude 8 h/day 24–32 days LAD 20 180 sodium pentobarbital IR/AAR Means±SE 9 41.2 3.9 9 58.2 2.2
Neckár 2005b [39] W M 250–280 g 7000 m altitude 8 h/day 24–32 days LAD 20 180 sodium pentobarbital IR/AAR Means±SE 9 33.9 3.8 9 58.9 3.7
Neckár 2004 [40] W M 250–280 g 7000 m altitude 8 h/day 5 days a week 35 days LAD 30 240 sodium pentobarbiton IR/AAR Means±SE 11 48 2.2 15 69.2 1.7
Neckár 2002a [41] W M 250–280 g 5000 m altitude 8 h/day 5 days a week 24–32 days G 20 240 sodium pentobarbiton IR/AAR Means±SE 16 52.7 2.5 10 62.2 2
Neckár 2002b [41] W M 250–280 g 5000 m altitude 8 h/day 5 days a week 24–32 days G 20 240 sodium pentobarbiton IR/AAR Means±SE 9 51.5 2.2 9 60.2 2.6
Neckár 2002c [42] W M 250–280 g 7000 m altitude 8 h/day 5 days a week 24–30 days LAD 30 240 sodium pentobarbiton IR/AAR Means±SE 19 50.2 1.9 10 66.6 2.3
  1. Different letters refer to different studies and experimental groups within each included study. SD, Sprague-Dawley rats; W, Wistar rats; M, male; 7000 m altitude (around PB 308 mmHg, PO2 65 mmHg, FiO2 9.75%), 5000 m altitude (around PB 404 mmHg, PO2 85 mmHg, FiO2 12.95%), 3000 m altitude (around PB 525 mmHg, PO2 110 mmHg, FiO2 14.4%), sea-level (around PB 760 mmHg, PO2 159 mmHg, FiO2 20.95%); G, global ischemia; LAD, left anterior descending; LCA, left coronary artery; IS, infarct size; VS, ventricle size; AAR, area at risk; SEM, standard error of the mean; STD, standard deviation of the mean. The main characteristics included (1) study, year, reference; (2) species; (3) sex; (4) age or weight; (5) oxygen concentration (Fi O2); (6) daily hypoxic exposure (hour); (7) total stimulus duration (day); (8) ligation of coronary artery; (9) duration of index ischemia duration (min); (10) reperfusion duration (h); (11) induction anesthetic; (12) measurement of IS; (13) measurement of variance; (14) control group sample size; (15) control group mean infarct size; (16) control group variance; (17) conditioning group sample size; (18) conditioning group mean infarct size; (19) conditioning group variance