Intermittent hypoxia reduces infarct size in rats with acute myocardial infarction: a systematic review and meta-analysis

Hu, Ke; Deng, Wei; Yang, Jing; Wei, Yu; Wen, Chaolin; Li, Xingsheng; Chen, Qingwei; Ke, Dazhi; Li, Guiqiong

doi:10.1186/s12872-020-01702-y

Table 1 Summary of the main characteristics of included studies

From: Intermittent hypoxia reduces infarct size in rats with acute myocardial infarction: a systematic review and meta-analysis

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19
Yuan 2017 [4]	SD	M	330–350 g	5000 m altitude	6 h/day	28 days	G	30	120	sodium pentobarbital	IR/VR	Means±SD	4	12.8	2.0	4	38.4	5
Li 2016 [24]	SD	M	220 ±? g	5000 m altitude	6 h/day	28 days	G	30	120	sodium pentobarbital	IR/VR	Means±SD	6	27.3	5.9	6	48.3	7.5
Kasparova 2015 [3]	W	M	300–380 g	Normobaric FiO2 10%	8 h/day	21 days	LAD	20	180	Sodium pentobarbital	IR/AAR	Means±SE	10	46.4	4.2	10	62.7	2.7
Meng 2014 [25]	W	M	150–180 g	5000 m altitude	6 h/day	42 days	LAD	30	240	25% ethylurethanm solution	IR/AAR	Means±SE	7	12.5	1.6	7	30.9	6.8
Ma 2014 [26]	SD	M	neonate	3000 m altitude	5 h/day	42 days	G	30	120	sodium pentobarbital	IR/VR	Means±SE	6	26.7	0.4	6	48.6	2.2
Gao 2014 [27]	SD	M	100–130 g	5000 m altitude	4 h/day	28 days	G	30	120	sodium pentobarbital	IR/AAR	Means±SE	5	22.58	3	5	35.9	4.1
Manukhina 2013 [28]	W	M	250–280 g	Normobaric FiO2 9.5–10%	4 min/cycle	5–8 cycles/day 20 days	LAD	30	120	urethane	IR/AAR	Means±SE	10	17.5	2.6	9	30.6	5.1
Ramond 2013a [16]	W	M	250–350 g	Normobaric FiO2 5%	40s/min 8 h/d	14 days	G	30	120	sodium pentobarbital	IR/VR	Means±SE	7	36.0	2.8	7	21.8	3.1
Ramond 2013b [16]	W	M	250–350 g	Normobaric FiO2 5%	40s/min 8 h/d	14 days	G	30	120	sodium pentobarbital	IR/VR	Means±SE	8	40.3	3.5	8	29.4	3.7
Milano 2011 [17]	SD	M	251 ± 2 g	Normobaric FiO2 10%	23 h/day	15 days	LAD	30	180	sodium pentobarbital	IR/AAR	Means±SE	7	68.5	2.4	7	46.5	4.4
Wang 2011 [29]	SD	M	100–120 g	5000 m altitude	4 h/day	28 days	G	30	120	pentobarbital sodium	IR/AAR	Means±SE	5	20.5	5.3	5	42.1	3.8
Belaidi 2008 [30]	W	M	330–350 g	Normobaric FiO2 10%	4 h/day	1 day	G	30	120	pentobarbital sodium	IR/VR	Means±SE	8	15.9	5.6	8	33.8	5
Yeung 2007a [31]	SD	M	290–320 g	Normobaric FiO2 10%	6 h/day	3 days	LCA	30	120	decapitated	IR/AAR	Means±SE	6	32.7	1.2	6	35.1	1.8
Yeung 2007b [31]	SD	M	290–320 g	Normobaric FiO2 10%	6 h/day	7 days	LCA	30	120	decapitated	IR/AAR	Means±SE	6	26.5	0.7	6	34.8	1.1
Yeung 2007c [31]	SD	M	290–320 g	Normobaric FiO2 10%	6 h/day	14 days	LCA	30	120	decapitated	IR/AAR	Means±SE	6	31.71	1.0	6	37.7	2.0
Ravingerová 2007 [32]	W	M	250–280 g	7000 m altitude	8 h/day	5 days/week 25–30 days	LAD	20	180	sodium pentobarbiton	IR/AAR	Means±SE	8	51.8	4.4	8	64.9	5.1
Kolár 2007 [33]	W	M	250–280 g	7000 m altitude	8 h/day	24–30 days	LAD	20	180	sodium pentobarbital	IR/AAR	Means±SE	8	27.7	4.9	8	56.7	4.5
Béguin 2007 [34]	W	M	330–380 g	5000 m altitude	4 h/d	1 day	G	30	120	sodium pentobarbital	IR/VR	Means±SE	8	22.2	2.4	8	33.8	2.6
Zhu 2006 [35]	SD	M	100–130 g	5000 m altitude	6 h/day	42 days	G	30	120	sodium pentobarbital	IR/VR (LV area)	Means±SE	7	24	1.9	7	42.1	2.1
Kolár 2005 [36]	W	M	5–6 weeks	7000 m altitude	8 h/day	35–42 days	LAD	20	180	sodium pentobarbiton	IR/AAR	Means±SE	7	43.2	3.3	7	59.2	4.4
Béguin 2005 [37]	W	M	330–380 g	Normobaric FiO2 10%	40s/min 4 h/d	1d	G	30	120	sodium pentobarbiton	IR/VR (LV area)	Means±SE	11	21.8	3.1	9	33.5	2.5
Joyeux-Faure 2005 [38]	W	M	220–240 g	Normobaric FiO2 5%	40s/min 8 h/d	35 days	G	30	120	sodium pentobarbiton	IR/VR	Means±SE	9	46.9	3.6	9	26.1	2.8
Neckár 2005a [39]	W	M	250–280 g	7000 m altitude	8 h/day	24–32 days	LAD	20	180	sodium pentobarbital	IR/AAR	Means±SE	9	41.2	3.9	9	58.2	2.2
Neckár 2005b [39]	W	M	250–280 g	7000 m altitude	8 h/day	24–32 days	LAD	20	180	sodium pentobarbital	IR/AAR	Means±SE	9	33.9	3.8	9	58.9	3.7
Neckár 2004 [40]	W	M	250–280 g	7000 m altitude	8 h/day	5 days a week 35 days	LAD	30	240	sodium pentobarbiton	IR/AAR	Means±SE	11	48	2.2	15	69.2	1.7
Neckár 2002a [41]	W	M	250–280 g	5000 m altitude	8 h/day	5 days a week 24–32 days	G	20	240	sodium pentobarbiton	IR/AAR	Means±SE	16	52.7	2.5	10	62.2	2
Neckár 2002b [41]	W	M	250–280 g	5000 m altitude	8 h/day	5 days a week 24–32 days	G	20	240	sodium pentobarbiton	IR/AAR	Means±SE	9	51.5	2.2	9	60.2	2.6
Neckár 2002c [42]	W	M	250–280 g	7000 m altitude	8 h/day	5 days a week 24–30 days	LAD	30	240	sodium pentobarbiton	IR/AAR	Means±SE	19	50.2	1.9	10	66.6	2.3

Different letters refer to different studies and experimental groups within each included study. SD, Sprague-Dawley rats; W, Wistar rats; M, male; 7000 m altitude (around PB 308 mmHg, PO2 65 mmHg, FiO2 9.75%), 5000 m altitude (around PB 404 mmHg, PO2 85 mmHg, FiO2 12.95%), 3000 m altitude (around PB 525 mmHg, PO2 110 mmHg, FiO2 14.4%), sea-level (around PB 760 mmHg, PO2 159 mmHg, FiO2 20.95%); G, global ischemia; LAD, left anterior descending; LCA, left coronary artery; IS, infarct size; VS, ventricle size; AAR, area at risk; SEM, standard error of the mean; STD, standard deviation of the mean. The main characteristics included (1) study, year, reference; (2) species; (3) sex; (4) age or weight; (5) oxygen concentration (Fi O2); (6) daily hypoxic exposure (hour); (7) total stimulus duration (day); (8) ligation of coronary artery; (9) duration of index ischemia duration (min); (10) reperfusion duration (h); (11) induction anesthetic; (12) measurement of IS; (13) measurement of variance; (14) control group sample size; (15) control group mean infarct size; (16) control group variance; (17) conditioning group sample size; (18) conditioning group mean infarct size; (19) conditioning group variance

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ISSN: 1471-2261

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