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Table 1 The functional enrichment analyses of DEGs ranked by P-value

From: Investigation of the underlying genes and mechanism of familial hypercholesterolemia through bioinformatics analysis

Term Count Genes P-Value
GO-BPs
 GO:0001843 ~ neural tube closure 4 TMED2, SKI, PRKACB, VASP 0.006332314
 GO:0010942 ~ positive regulation of cell death 3 AKR1C3, UCP2, TRIM13 0.008780361
 GO:0007596 ~ blood coagulation 5 P2RX5, F5, ENPP4, PRKACB, WAS 0.012574205
 GO:0007229 ~ integrin-mediated signaling pathway 4 ITGAL, ITGAV, PRAM1, ZYX 0.012578224
 GO:0038027 ~ apolipoprotein A-I-mediated signaling pathway 2 ABCA7, ITGAV 0.024181939
 GO:0051289 ~ protein homotetramerization 3 CRTC2, VASP, GOLGA2 0.034735707
 GO:0048208 ~ COPII vesicle coating 3 F5, TMED2, GOLGA2 0.035801513
 GO:0035019 ~ somatic stem cell population maintenance 3 BCL9L, SKI, POLR2A 0.040189117
 GO:0006888 ~ ER to Golgi vesicle-mediated transport 4 F5, TMED2, GOLGA2, SPTAN1 0.043542377
 GO:0098609 ~ cell-cell adhesion 5 PKM, BAG3, VASP, GOLGA2, SPTAN1 0.043641603
GO-CCs
 GO:0005913 ~ cell-cell adherens junction 7 PKM, TLN1, BAG3, ZYX, VASP, GOLGA2, SPTAN1 0.004005355
 GO:0032587 ~ ruffle membrane 4 ABCA7, TLN1, ITGAV, IFIT5 0.00665283
 GO:0005886 ~ plasma membrane 30 ABCA7, ITGAL, TLN1, LRRC8B, ENPP4, MMP25, PKM, DYSF, ITGAV, BAG3, ANKRD11, CD4, PRKACB, KLRF1, ZYX, FLVCR1, FMNL1, KLRB1, RHBDF2, CD160, EDA2R, VASP, P2RX5, LSP1, PRKD2, NEDD1, F5, IFIT5, P2RY14, CYBRD1 0.010121246
 GO:0016020 ~ membrane 19 FMNL1, ITGAL, MOB4, ENPP4, MAP 4 K1, RPS9, PRRC2A, CAD, MMP25, TAPBP, LSP1, PIGK, F5, PEX2, ITGAV, CD4, KLRF1, NCOR2, SPTAN1 0.011799738
 GO:0070062 ~ extracellular exosome 22 FMNL1, ITGAL, CRTC2, TLN1, ENPP4, RPS9, MINK1, PRRC2A, CAD, WAS, VASP, AKR1C3, PKM, LSP1, DYSF, CLIC3, UBA1, ITGAV, BEX5, CYBRD1, PRKACB, SPTAN1 0.017083511
 GO:1903561 ~ extracellular vesicle 3 PKM, F5, SPTAN1 0.022786951
 GO:0017053 ~ transcriptional repressor complex 3 MIER1, SKI, NCOR2 0.027213685
 GO:0005654 ~ nucleoplasm 21 CRTC2, SF1, RPS9, CAD, SKI, BOD1L1, POLR2A, FEM1C, PRKD2, NEDD1, HNRNPUL1, MIER1, SRRM2, FYTTD1, ANKRD11, SP4, BCL9L, KPNA5, PRKACB, NCOR2, CHD3 0.02939589
 GO:0033116 ~ endoplasmic reticulum-Golgi intermediate compartment membrane 3 F5, TMED2, GOLGA2 0.035966686
 GO:0005737 ~ cytoplasm 33 CRTC2, TLN1, MOB4, LRRC8B, MAP 4 K1, TRIM13, PRRC2A, AKR1C3, DNAJC17, PKM, MIER1, BAG3, ANKRD11, HECTD3, ZYX, MTMR6, CHD3, C15ORF39, RPS9, MINK1, SKI, VASP, P2RX5, FEM1C, PRKD2, CLIC3, UBA1, RFK, SP4, BEX5, CMIP, KPNA5, FPGT 0.045491399
 GO:0032580 ~ Golgi cisterna membrane 3 MOB4, TMED2, GOLGA2 0.049065899
GO-MFs
 GO:0005515 ~ protein binding 62 RARRES3, TLN1, LRRC8B, HMGN4, TAPBP, PKM, PIGK, DYSF, PEX2, MIER1, BAG3, ZYX, PRKACB, MATK, FLVCR1, GOLGA2, FMNL1, GZMA, SF1, CD160, MINK1, LENG8, WAS, VASP, PRKD2, F5, CLIC3, PRAM1, CYBRD1, KPNA5, CMIP, ITGAL, CRTC2, MOB4, TRIM13, MAP 4 K1, PRRC2A, CIC, POLR2A, TMED2, CD69, ITGAV, HECTD3, LIMD2, CD4, MTMR6, TRAM1, CHD3, EDA2R, RPS9, ZNF26, SKI, FEM1C, MRFAP1L1, HNRNPUL1, UCP2, UBA1, FYTTD1, SP4, BEX5, NCOR2, SPTAN1 0.0000906709830702394
 GO:0098641 ~ cadherin binding involved in cell-cell adhesion 6 PKM, TLN1, BAG3, VASP, GOLGA2, SPTAN1 0.014824041
 GO:0004888 ~ transmembrane signaling receptor activity 5 KLRB1, P2RX5, CD69, CD4, KLRF1 0.02204474
 GO:0044822 ~ poly(A) RNA binding 12 PKM, HNRNPUL1, UBA1, FYTTD1, SRRM2, IFIT5, SF1, RPS9, PRRC2A, ZYX, CHD3, POLR2A 0.023879125
 GO:0032393 ~ MHC class I receptor activity 2 CD160, KLRF1 0.02949141
 GO:0005522 ~ profilin binding 2 FMNL1, VASP 0.043913166