Table 1 The functional enrichment analyses of DEGs ranked by P-value
Term | Count | Genes | P-Value |
|---|---|---|---|
GO-BPs | |||
 GO:0001843 ~ neural tube closure | 4 | TMED2, SKI, PRKACB, VASP | 0.006332314 |
 GO:0010942 ~ positive regulation of cell death | 3 | AKR1C3, UCP2, TRIM13 | 0.008780361 |
 GO:0007596 ~ blood coagulation | 5 | P2RX5, F5, ENPP4, PRKACB, WAS | 0.012574205 |
 GO:0007229 ~ integrin-mediated signaling pathway | 4 | ITGAL, ITGAV, PRAM1, ZYX | 0.012578224 |
 GO:0038027 ~ apolipoprotein A-I-mediated signaling pathway | 2 | ABCA7, ITGAV | 0.024181939 |
 GO:0051289 ~ protein homotetramerization | 3 | CRTC2, VASP, GOLGA2 | 0.034735707 |
 GO:0048208 ~ COPII vesicle coating | 3 | F5, TMED2, GOLGA2 | 0.035801513 |
 GO:0035019 ~ somatic stem cell population maintenance | 3 | BCL9L, SKI, POLR2A | 0.040189117 |
 GO:0006888 ~ ER to Golgi vesicle-mediated transport | 4 | F5, TMED2, GOLGA2, SPTAN1 | 0.043542377 |
 GO:0098609 ~ cell-cell adhesion | 5 | PKM, BAG3, VASP, GOLGA2, SPTAN1 | 0.043641603 |
GO-CCs | |||
 GO:0005913 ~ cell-cell adherens junction | 7 | PKM, TLN1, BAG3, ZYX, VASP, GOLGA2, SPTAN1 | 0.004005355 |
 GO:0032587 ~ ruffle membrane | 4 | ABCA7, TLN1, ITGAV, IFIT5 | 0.00665283 |
 GO:0005886 ~ plasma membrane | 30 | ABCA7, ITGAL, TLN1, LRRC8B, ENPP4, MMP25, PKM, DYSF, ITGAV, BAG3, ANKRD11, CD4, PRKACB, KLRF1, ZYX, FLVCR1, FMNL1, KLRB1, RHBDF2, CD160, EDA2R, VASP, P2RX5, LSP1, PRKD2, NEDD1, F5, IFIT5, P2RY14, CYBRD1 | 0.010121246 |
 GO:0016020 ~ membrane | 19 | FMNL1, ITGAL, MOB4, ENPP4, MAP 4 K1, RPS9, PRRC2A, CAD, MMP25, TAPBP, LSP1, PIGK, F5, PEX2, ITGAV, CD4, KLRF1, NCOR2, SPTAN1 | 0.011799738 |
 GO:0070062 ~ extracellular exosome | 22 | FMNL1, ITGAL, CRTC2, TLN1, ENPP4, RPS9, MINK1, PRRC2A, CAD, WAS, VASP, AKR1C3, PKM, LSP1, DYSF, CLIC3, UBA1, ITGAV, BEX5, CYBRD1, PRKACB, SPTAN1 | 0.017083511 |
 GO:1903561 ~ extracellular vesicle | 3 | PKM, F5, SPTAN1 | 0.022786951 |
 GO:0017053 ~ transcriptional repressor complex | 3 | MIER1, SKI, NCOR2 | 0.027213685 |
 GO:0005654 ~ nucleoplasm | 21 | CRTC2, SF1, RPS9, CAD, SKI, BOD1L1, POLR2A, FEM1C, PRKD2, NEDD1, HNRNPUL1, MIER1, SRRM2, FYTTD1, ANKRD11, SP4, BCL9L, KPNA5, PRKACB, NCOR2, CHD3 | 0.02939589 |
 GO:0033116 ~ endoplasmic reticulum-Golgi intermediate compartment membrane | 3 | F5, TMED2, GOLGA2 | 0.035966686 |
 GO:0005737 ~ cytoplasm | 33 | CRTC2, TLN1, MOB4, LRRC8B, MAP 4 K1, TRIM13, PRRC2A, AKR1C3, DNAJC17, PKM, MIER1, BAG3, ANKRD11, HECTD3, ZYX, MTMR6, CHD3, C15ORF39, RPS9, MINK1, SKI, VASP, P2RX5, FEM1C, PRKD2, CLIC3, UBA1, RFK, SP4, BEX5, CMIP, KPNA5, FPGT | 0.045491399 |
 GO:0032580 ~ Golgi cisterna membrane | 3 | MOB4, TMED2, GOLGA2 | 0.049065899 |
GO-MFs | |||
 GO:0005515 ~ protein binding | 62 | RARRES3, TLN1, LRRC8B, HMGN4, TAPBP, PKM, PIGK, DYSF, PEX2, MIER1, BAG3, ZYX, PRKACB, MATK, FLVCR1, GOLGA2, FMNL1, GZMA, SF1, CD160, MINK1, LENG8, WAS, VASP, PRKD2, F5, CLIC3, PRAM1, CYBRD1, KPNA5, CMIP, ITGAL, CRTC2, MOB4, TRIM13, MAP 4 K1, PRRC2A, CIC, POLR2A, TMED2, CD69, ITGAV, HECTD3, LIMD2, CD4, MTMR6, TRAM1, CHD3, EDA2R, RPS9, ZNF26, SKI, FEM1C, MRFAP1L1, HNRNPUL1, UCP2, UBA1, FYTTD1, SP4, BEX5, NCOR2, SPTAN1 | 0.0000906709830702394 |
 GO:0098641 ~ cadherin binding involved in cell-cell adhesion | 6 | PKM, TLN1, BAG3, VASP, GOLGA2, SPTAN1 | 0.014824041 |
 GO:0004888 ~ transmembrane signaling receptor activity | 5 | KLRB1, P2RX5, CD69, CD4, KLRF1 | 0.02204474 |
 GO:0044822 ~ poly(A) RNA binding | 12 | PKM, HNRNPUL1, UBA1, FYTTD1, SRRM2, IFIT5, SF1, RPS9, PRRC2A, ZYX, CHD3, POLR2A | 0.023879125 |
 GO:0032393 ~ MHC class I receptor activity | 2 | CD160, KLRF1 | 0.02949141 |
 GO:0005522 ~ profilin binding | 2 | FMNL1, VASP | 0.043913166 |