From: Outcomes of Cardiac Resynchronization Therapy in Patients with Hypothyroidism and Heart Failure
Variable | Univariate Analysis | Multivariate Analysis | ||||
---|---|---|---|---|---|---|
HR | 95% CI | P Value | HR | 95% CI | P Value | |
Age | 0.99 | 0.97–1.01 | 0.42 |  |  |  |
Female | 0.33 | 0.17–0.64 | 0.001 | 1.59 | 0.66–3.86 | 0.30 |
Primary prevention | 0.46 | 0.28–0.74 | 0.002 | 0.15 | 0.02–1.21 | 0.07 |
Hypertension | 0.85 | 0.53–1.38 | 0.52 |  |  |  |
Diabetes mellitus | 0.79 | 0.45–1.38 | 0.41 |  |  |  |
Chronic kidney disease | 1.90 | 1.16–3.11 | 0.01 | 1.81 | 0.95–3.48 | 0.07 |
Hyperlipidemia | 0.75 | 0.47–1.22 | 0.25 |  |  |  |
Atrial fibrillation | 1.18 | 0.74–1.89 | 0.48 |  |  |  |
ICM | 1.60 | 0.98–2.59 | 0.06 | 0.99 | 0.51–1.95 | 0.98 |
LBBB | 0.74 | 0.46–1.19 | 0.22 |  |  |  |
QRS duration | 1.00 | 0.99–1.01 | 0.78 |  |  |  |
NYHA functional class | 1.31 | 0.80–2.17 | 0.29 |  |  |  |
LVEF | 0.99 | 0.95–1.03 | 0.55 |  |  |  |
TRT | 0.74 | 0.45–1.23 | 0.25 |  |  |  |
amiodarone | 1.79 | 1.10–2.89 | 0.02 | 0.36 | 0.05–2.81 | 0.33 |
Statin | 1.14 | 0.71–1.83 | 0.57 |  |  |  |
Digoxin | 1.03 | 0.64–1.65 | 0.91 |  |  |  |
b-Blocker | 0.87 | 0.45–1.65 | 0.66 |  |  |  |
ACEI/ARB | 0.78 | 0.45–1.36 | 0.39 |  |  |  |
Aldactone | 0.68 | 0.39–1.17 | 0.16 |  |  |  |
Furosemide | 1.23 | 0.71–2.11 | 0.46 |  |  |  |
CRT Response | 0.44 | 0.24–0.80 | 0.007 | 0.58 | 0.31–1.12 | 0.11 |
TSH per 5 mIU/L | 1.35 | 1.12–1.63 | 0.002 | 1.44 | 1.13–1.84 | 0.004 |