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Table 4 Univariate and Multivariate Cox Regression Models to Identify Predictors for Appropriate ICD Therapy in Patients with Hypothyroidism

From: Outcomes of Cardiac Resynchronization Therapy in Patients with Hypothyroidism and Heart Failure

Variable

Univariate Analysis

Multivariate Analysis

HR

95% CI

P Value

HR

95% CI

P Value

Age

0.99

0.97–1.01

0.42

   

Female

0.33

0.17–0.64

0.001

1.59

0.66–3.86

0.30

Primary prevention

0.46

0.28–0.74

0.002

0.15

0.02–1.21

0.07

Hypertension

0.85

0.53–1.38

0.52

   

Diabetes mellitus

0.79

0.45–1.38

0.41

   

Chronic kidney disease

1.90

1.16–3.11

0.01

1.81

0.95–3.48

0.07

Hyperlipidemia

0.75

0.47–1.22

0.25

   

Atrial fibrillation

1.18

0.74–1.89

0.48

   

ICM

1.60

0.98–2.59

0.06

0.99

0.51–1.95

0.98

LBBB

0.74

0.46–1.19

0.22

   

QRS duration

1.00

0.99–1.01

0.78

   

NYHA functional class

1.31

0.80–2.17

0.29

   

LVEF

0.99

0.95–1.03

0.55

   

TRT

0.74

0.45–1.23

0.25

   

amiodarone

1.79

1.10–2.89

0.02

0.36

0.05–2.81

0.33

Statin

1.14

0.71–1.83

0.57

   

Digoxin

1.03

0.64–1.65

0.91

   

b-Blocker

0.87

0.45–1.65

0.66

   

ACEI/ARB

0.78

0.45–1.36

0.39

   

Aldactone

0.68

0.39–1.17

0.16

   

Furosemide

1.23

0.71–2.11

0.46

   

CRT Response

0.44

0.24–0.80

0.007

0.58

0.31–1.12

0.11

TSH per 5 mIU/L

1.35

1.12–1.63

0.002

1.44

1.13–1.84

0.004

  1. Abbreviations as in Table 1. TSH thyroid-stimulating hormone