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Table 4 Univariate and Multivariate Cox Regression Models to Identify Predictors for Appropriate ICD Therapy in Patients with Hypothyroidism

From: Outcomes of Cardiac Resynchronization Therapy in Patients with Hypothyroidism and Heart Failure

Variable Univariate Analysis Multivariate Analysis
HR 95% CI P Value HR 95% CI P Value
Age 0.99 0.97–1.01 0.42    
Female 0.33 0.17–0.64 0.001 1.59 0.66–3.86 0.30
Primary prevention 0.46 0.28–0.74 0.002 0.15 0.02–1.21 0.07
Hypertension 0.85 0.53–1.38 0.52    
Diabetes mellitus 0.79 0.45–1.38 0.41    
Chronic kidney disease 1.90 1.16–3.11 0.01 1.81 0.95–3.48 0.07
Hyperlipidemia 0.75 0.47–1.22 0.25    
Atrial fibrillation 1.18 0.74–1.89 0.48    
ICM 1.60 0.98–2.59 0.06 0.99 0.51–1.95 0.98
LBBB 0.74 0.46–1.19 0.22    
QRS duration 1.00 0.99–1.01 0.78    
NYHA functional class 1.31 0.80–2.17 0.29    
LVEF 0.99 0.95–1.03 0.55    
TRT 0.74 0.45–1.23 0.25    
amiodarone 1.79 1.10–2.89 0.02 0.36 0.05–2.81 0.33
Statin 1.14 0.71–1.83 0.57    
Digoxin 1.03 0.64–1.65 0.91    
b-Blocker 0.87 0.45–1.65 0.66    
ACEI/ARB 0.78 0.45–1.36 0.39    
Aldactone 0.68 0.39–1.17 0.16    
Furosemide 1.23 0.71–2.11 0.46    
CRT Response 0.44 0.24–0.80 0.007 0.58 0.31–1.12 0.11
TSH per 5 mIU/L 1.35 1.12–1.63 0.002 1.44 1.13–1.84 0.004
  1. Abbreviations as in Table 1. TSH thyroid-stimulating hormone