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Table 3 Univariate and Multivariate Cox Regression Models to Identify Predictors for appropriate ICD therapy in All Patients

From: Outcomes of Cardiac Resynchronization Therapy in Patients with Hypothyroidism and Heart Failure

Variable Univariate Analysis Multivariate Analysis
HR 95% CI P Value HR 95% CI P Value
Age 0.99 0.98–1.00 0.08    
Female 0.41 0.29–0.59 < 0.001 0.45 0.27–0.75 0.002
Primary prevention 0.54 0.40–0.72 < 0.001 0.28 0.10–0.83 0.02
Hypertension 1.04 0.81–1.32 0.78    
Diabetes mellitus 1.01 0.78–1.32 0.92    
Chronic kidney disease 1.24 0.94–1.63 0.13    
Hyperlipidemia 1.09 0.86–1.39 0.48    
Atrial fibrillation 1.20 0.94–1.53 0.14    
ICM 1.13 0.89–1.44 0.32    
LBBB 0.67 0.52–0.85 0.001 0.72 0.50–1.05 0.08
QRS duration 0.997 0.992–1.001 0.17    
NYHA functional class 1.16 0.91–1.47 0.24    
LVEF 0.98 0.96–1.00 0.02 0.97 0.95–1.01 0.11
TRT 0.97 0.71–1.32 0.84    
Statin 1.02 0.80–1.30 0.87    
amiodarone 1.62 1.22–2.15 0.001 0.44 0.16–1.27 0.13
Digoxin 1.55 1.22–1.97 < 0.001 1.44 1.00–2.07 0.05
ACEARB 0.77 0.57–1.05 0.09 0.73 0.45–1.18 0.20
Aldactone 1.07 0.82–1.38 0.62    
Furosemide 1.30 0.99–1.71 0.06 1.13 0.75–1.70 0.54
CRT response 0.43 0.32–0.59 < 0.001 0.46 0.32–0.68 < 0.001
TSH per 5 mIU/L 1.05 1.02–1.09 0.002 1.23 1.01–1.50 0.04
  1. Abbreviations as in Table 1. TSH thyroid-stimulating hormone