From: Outcomes of Cardiac Resynchronization Therapy in Patients with Hypothyroidism and Heart Failure
Variable | Univariate Analysis | Multivariate Analysisa | Multivariate Analysisb | ||||||
---|---|---|---|---|---|---|---|---|---|
HR | 95% CI | P Value | HR | 95% CI | P Value | HR | 95% CI | P Value | |
Age | 1.04 | 1.04–1.05 | < 0.001 | 1.04 | 1.03–1.06 | < 0.001 | 1.04 | 1.03–1.06 | < 0.001 |
Female | 0.54 | 0.44–0.68 | < 0.001 | 0.73 | 0.52–1.04 | 0.09 | 0.77 | 0.53–1.12 | 0.18 |
CRT-D | 0.71 | 0.56–0.91 | 0.007 | 0.72 | 0.47–1.12 | 0.14 | 0.74 | 0.45–1.22 | 0.23 |
Hypertension | 0.97 | 0.83–1.14 | 0.73 |  |  |  |  |  |  |
Diabetes mellitus | 1.49 | 1.26–1.76 | < 0.001 | 1.77 | 1.35–2.31 | < 0.001 | 1.84 | 1.35–2.49 | < 0.001 |
Chronic kidney disease | 2.46 | 2.09–2.89 | < 0.001 | 1.47 | 1.12–1.93 | 0.006 | 1.45 | 1.07–1.98 | 0.02 |
Hyperlipidemia | 0.99 | 0.85–1.16 | 0.94 |  |  |  |  |  |  |
Atrial fibrillation | 1.33 | 1.13–1.55 | < 0.001 | 1.18 | 0.91–1.53 | 0.20 | 1.07 | 0.79–1.43 | 0.67 |
ICM | 2.02 | 1.71–2.38 | < 0.001 | 1.14 | 0.86–1.50 | 0.36 | 1.15 | 0.856–1.57 | 0.37 |
LBBB | 0.70 | 0.60–0.83 | < 0.001 | 0.75 | 0.58–0.97 | 0.03 | 0.78 | 0.58–1.05 | 0.11 |
QRS duration | 1.00 | 0.99–1.00 | 0.63 |  |  |  |  |  |  |
NYHA functional class | 1.95 | 1.66–2.30 | < 0.001 | 1.30 | 1.01–1.68 | 0.05 | 1.24 | 0.93–1.65 | 0.14 |
LVEF | 0.99 | 0.98–1.00 | 0.064 | 0.98 | 0.96–1.00 | 0.03 | 0.98 | 0.96–1.00 | 0.10 |
TRT | 1.38 | 1.14–1.67 | 0.001 | 1.20 | 0.71–2.04 | 0.50 | 1.43 | 1.02–2.02 | 0.04 |
Amiodarone | 1.33 | 1.09–1.61 | 0.005 | 1.20 | 0.87–1.66 | 0.27 | 1.25 | 0.89–1.76 | 0.20 |
Statin | 1.05 | 0.90–1.23 | 0.54 |  |  |  |  |  |  |
Digoxin | 1.31 | 1.12–1.54 | 0.001 | 1.42 | 1.10–1.85 | 0.008 | 1.46 | 1.09–1.95 | 0.01 |
b-Blocker | 0.90 | 0.71–1.15 | 0.41 |  |  |  |  |  |  |
ACEI/ARB | 0.67 | 0.55–0.81 | < 0.001 | 0.86 | 0.61–1.23 | 0.41 | 0.76 | 0.52–1.11 | 0.16 |
Aldactone | 1.00 | 0.84–1.18 | 0.96 |  |  |  |  |  |  |
Furosemide | 1.36 | 1.14–1.64 | 0.001 | 1.26 | 0.93–1.71 | 0.14 | 1.3 | 0.91–1.86 | 0.15 |
CRT response | 0.41 | 0.32–0.52 | < 0.001 | 0.42 | 0.32–0.54 | < 0.001 | 0.45 | 0.33–0.60 | < 0.001 |
Hypothyroidism | 1.37 | 1.15–1.62 | < 0.001 | 1.16 | 0.72–1.89 | 0.54 | – | – | – |
TSH per 5 mIU/L | 1.41 | 1.29–1.55 | < 0.001 | – | – | – | 0.94 | 0.74–1.19 | 0.60 |