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Table 2 Univariate and Multivariate Cox Regression Models to Identify Predictors for All-Cause Mortality in All Patients

From: Outcomes of Cardiac Resynchronization Therapy in Patients with Hypothyroidism and Heart Failure

Variable

Univariate Analysis

Multivariate Analysisa

Multivariate Analysisb

HR

95% CI

P Value

HR

95% CI

P Value

HR

95% CI

P Value

Age

1.04

1.04–1.05

< 0.001

1.04

1.03–1.06

< 0.001

1.04

1.03–1.06

< 0.001

Female

0.54

0.44–0.68

< 0.001

0.73

0.52–1.04

0.09

0.77

0.53–1.12

0.18

CRT-D

0.71

0.56–0.91

0.007

0.72

0.47–1.12

0.14

0.74

0.45–1.22

0.23

Hypertension

0.97

0.83–1.14

0.73

      

Diabetes mellitus

1.49

1.26–1.76

< 0.001

1.77

1.35–2.31

< 0.001

1.84

1.35–2.49

< 0.001

Chronic kidney disease

2.46

2.09–2.89

< 0.001

1.47

1.12–1.93

0.006

1.45

1.07–1.98

0.02

Hyperlipidemia

0.99

0.85–1.16

0.94

      

Atrial fibrillation

1.33

1.13–1.55

< 0.001

1.18

0.91–1.53

0.20

1.07

0.79–1.43

0.67

ICM

2.02

1.71–2.38

< 0.001

1.14

0.86–1.50

0.36

1.15

0.856–1.57

0.37

LBBB

0.70

0.60–0.83

< 0.001

0.75

0.58–0.97

0.03

0.78

0.58–1.05

0.11

QRS duration

1.00

0.99–1.00

0.63

      

NYHA functional class

1.95

1.66–2.30

< 0.001

1.30

1.01–1.68

0.05

1.24

0.93–1.65

0.14

LVEF

0.99

0.98–1.00

0.064

0.98

0.96–1.00

0.03

0.98

0.96–1.00

0.10

TRT

1.38

1.14–1.67

0.001

1.20

0.71–2.04

0.50

1.43

1.02–2.02

0.04

Amiodarone

1.33

1.09–1.61

0.005

1.20

0.87–1.66

0.27

1.25

0.89–1.76

0.20

Statin

1.05

0.90–1.23

0.54

      

Digoxin

1.31

1.12–1.54

0.001

1.42

1.10–1.85

0.008

1.46

1.09–1.95

0.01

b-Blocker

0.90

0.71–1.15

0.41

      

ACEI/ARB

0.67

0.55–0.81

< 0.001

0.86

0.61–1.23

0.41

0.76

0.52–1.11

0.16

Aldactone

1.00

0.84–1.18

0.96

      

Furosemide

1.36

1.14–1.64

0.001

1.26

0.93–1.71

0.14

1.3

0.91–1.86

0.15

CRT response

0.41

0.32–0.52

< 0.001

0.42

0.32–0.54

< 0.001

0.45

0.33–0.60

< 0.001

Hypothyroidism

1.37

1.15–1.62

< 0.001

1.16

0.72–1.89

0.54

–

–

–

TSH per 5 mIU/L

1.41

1.29–1.55

< 0.001

–

–

–

0.94

0.74–1.19

0.60

  1. a Multivariate analysis including Hypothyroidism. b Multivariate analysis including TSH value. Abbreviations as in Table 1. TSH thyroid-stimulating hormone