Table 2 Effect of sildenafil on clinical and echocardiographic parameters

Systolic arterial pressure, mm Hg

130 ± 14

133 ± 16

127 ± 12

132 ± 17

Diastolic arterial pressure, mm Hg

80 ± 11

79 ± 8

76 ± 10

79 ± 10

Heart rate, bpm

63 ± 8

62 ± 8

63 ± 7

62 ± 6

Pulmonary vascular resistance, Wood units

3.33 ± 0.64

2.69 ± 0.49^**§§

3.19 ± 0.47

3.16 ± 0.45

Acceleration time of RVOT, ms

83 ± 17

114 ± 24^**§§

87 ± 17

88 ± 14

Pulmonary artery systolic pressure, mm Hg

58.6 ± 14.9

41.6 ± 10.3^**§§

55.5 ± 13.5

56.4 ± 12.4

Transpulmonary gradient, mm Hg

23.3 ± 7.7

12.7 ± 9.1^**§§

22.1 ± 8.8

21.0 ± 7.1

LV end diastolic dimension, cm

5.30 ± 0.47

5.37 ± 0.51^*

5.14 ± 0.46

5.15 ± 0.42

Interventricular septum, cm

1.20 ± 0.10

1.14 ± 0.08^**§§

1.20 ± 0.09

1.20 ± 0.09

LV posterior wall, cm

1.20 ± 0.10

1.14 ± 0.08^**§§

1.20 ± 0.09

1.20 ± 0.09

LV mass index, g/m²

135 ± 52

111 ± 40^**

130 ± 44

131 ± 47

LA volume index, mL/m²

50.7 ± 7.4

44.5 ± 6.4^**§§

49.8 ± 8.5

50.2 ± 8.4

Mitral e′, cm/s

6.3 ± 1.4

7.3 ± 1.5^**

6.7 ± 1.6

6.6 ± 1.4

Mitral E, cm/s

86 ± 19

83 ± 16

81 ± 16

83 ± 16

Mitral E/e′ ratio

14.2 ± 4.2

11.8 ± 3.2^**

12.6 ± 3.7

13.2 ± 3.8

RV basal diameter, cm

4.80 ± 0.55

4.50 ± 0.52^**

4.69 ± 0.56

4.68 ± 0.54

RA volume index, mL/m²

45.4 ± 6.5

38.5 ± 6.3^**

46.6 ± 8.8

46.8 ± 8.6

Tricuspid e′, cm/s

8.2 ± 2.8

11.4 ± 2.6^**§§

8.9 ± 2.9

8.4 ± 2.5

Tricuspid Е/e′ ratio

7.2 ± 3.4^§

4.0 ± 1.4^**§

5.3 ± 1.8

5.9 ± 2.2

IVC size, cm

2.26 ± 0.33

1.89 ± 0.37^**§

2.08 ± 0.31

2.13 ± 0.35

IVC collapse with a sniff, %

34 ± 8^§

53 ± 13^**§§

42 ± 14

42 ± 13

TAPSE, cm

1.76 ± 0.38

2.18 ± 0.47^**§

1.88 ± 0.37

1.91 ± 0.37

TAPSE/PASP, mm/mm Hg

0.32 ± 0.09

0.55 ± 0.17^**§§

0.36 ± 0.13

0.36 ± 0.12

s′_RV, cm/s

9.6 ± 2.1

12.2 ± 3.2^**§

10.6 ± 2.0

10.7 ± 1.9

NT-proBNP, pg/mL

391 (190–582)

416 (227–671)

468 (205–720)

470 (195–697)