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Table 2 Effect of sildenafil on clinical and echocardiographic parameters

From: Phosphodiesterase 5 inhibitor sildenafil in patients with heart failure with preserved ejection fraction and combined pre- and postcapillary pulmonary hypertension: a randomized open-label pilot study

Variables Sildenafil Control
Baseline 6 months Baseline 6 months
Systolic arterial pressure, mm Hg 130 ± 14 133 ± 16 127 ± 12 132 ± 17
Diastolic arterial pressure, mm Hg 80 ± 11 79 ± 8 76 ± 10 79 ± 10
Heart rate, bpm 63 ± 8 62 ± 8 63 ± 7 62 ± 6
Pulmonary vascular resistance, Wood units 3.33 ± 0.64 2.69 ± 0.49**§§ 3.19 ± 0.47 3.16 ± 0.45
Acceleration time of RVOT, ms 83 ± 17 114 ± 24**§§ 87 ± 17 88 ± 14
Pulmonary artery systolic pressure, mm Hg 58.6 ± 14.9 41.6 ± 10.3**§§ 55.5 ± 13.5 56.4 ± 12.4
Transpulmonary gradient, mm Hg 23.3 ± 7.7 12.7 ± 9.1**§§ 22.1 ± 8.8 21.0 ± 7.1
LV end diastolic dimension, cm 5.30 ± 0.47 5.37 ± 0.51* 5.14 ± 0.46 5.15 ± 0.42
Interventricular septum, cm 1.20 ± 0.10 1.14 ± 0.08**§§ 1.20 ± 0.09 1.20 ± 0.09
LV posterior wall, cm 1.20 ± 0.10 1.14 ± 0.08**§§ 1.20 ± 0.09 1.20 ± 0.09
LV mass index, g/m2 135 ± 52 111 ± 40** 130 ± 44 131 ± 47
LA volume index, mL/m2 50.7 ± 7.4 44.5 ± 6.4**§§ 49.8 ± 8.5 50.2 ± 8.4
Mitral e′, cm/s 6.3 ± 1.4 7.3 ± 1.5** 6.7 ± 1.6 6.6 ± 1.4
Mitral E, cm/s 86 ± 19 83 ± 16 81 ± 16 83 ± 16
Mitral E/e′ ratio 14.2 ± 4.2 11.8 ± 3.2** 12.6 ± 3.7 13.2 ± 3.8
RV basal diameter, cm 4.80 ± 0.55 4.50 ± 0.52** 4.69 ± 0.56 4.68 ± 0.54
RA volume index, mL/m2 45.4 ± 6.5 38.5 ± 6.3** 46.6 ± 8.8 46.8 ± 8.6
Tricuspid e′, cm/s 8.2 ± 2.8 11.4 ± 2.6**§§ 8.9 ± 2.9 8.4 ± 2.5
Tricuspid Е/e′ ratio 7.2 ± 3.4§ 4.0 ± 1.4**§ 5.3 ± 1.8 5.9 ± 2.2
IVC size, cm 2.26 ± 0.33 1.89 ± 0.37**§ 2.08 ± 0.31 2.13 ± 0.35
IVC collapse with a sniff, % 34 ± 8§ 53 ± 13**§§ 42 ± 14 42 ± 13
TAPSE, cm 1.76 ± 0.38 2.18 ± 0.47**§ 1.88 ± 0.37 1.91 ± 0.37
TAPSE/PASP, mm/mm Hg 0.32 ± 0.09 0.55 ± 0.17**§§ 0.36 ± 0.13 0.36 ± 0.12
s′RV, cm/s 9.6 ± 2.1 12.2 ± 3.2**§ 10.6 ± 2.0 10.7 ± 1.9
NT-proBNP, pg/mL 391 (190–582) 416 (227–671) 468 (205–720) 470 (195–697)
  1. OT outflow tract, LA left atrial, IVC inferior vena cava, TAPSE tricuspid annular plane systolic excursion, PASP pulmonary artery systolic pressure, s′RV peak velocity at the tricuspid annulus
  2. *P < 0.05, **P < 0.01 vs baseline
  3. §P < 0.05, §§P < 0.01 vs corresponding value in control group