Fig. 4
An example of Doppler peak tricuspid regurgitation and right ventricular outflow tracings, and tricuspid annular plane systolic excursion in a study patient with HFpEF at baseline (left panel) vs. after 6-month sildenafil therapy (right panel). Sildenafil therapy was associated with improvements in pulmonary artery systolic pressure (a decrease in tricuspid regurgitation velocity, TVR), pulmonary vascular resistance (an increase in the time to peak velocity of right ventricular outflow velocity, AcTRVOT), and right ventricular systolic function (an increase in tricuspid annular plane systolic excursion, TAPSE)