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Table 2 Subgroup analyses for investigated outcomes

From: Comparison of efficacy and safety of drug-eluting versus uncoated balloon angioplasty for femoropopliteal arterial occlusive disease: a meta-analysis

Outcomes

Subgroup

WMD or RR and 95% CI

P value

Heterogeneity (%)

P value for Meta-regression

MLD at 6 months

Mean age (years)

≥ 70.0

0.37 (− 0.26 to 1.01)

0.247

90.4 (0.001)

< 0.001

<  70.0

0.94 (0.64 to 1.24)

< 0.001

70.0 (0.005)

Smoker (%)

≥ 50.0

0.63 (0.21 to 1.05)

0.003

76.9 (0.005)

< 0.001

<  50.0

0.91 (0.53 to 1.29)

< 0.001

81.7 (0.001)

DM (%)

≥ 50.0

0.63 (−0.55 to 1.81)

0.294

96.0 (< 0.001)

0.140

<  50.0

0.78 (0.57 to 1.00)

< 0.001

66.1 (0.011)

Hyperlipidemia (%)

≥ 60.0

0.74 (−0.14 to 1.61)

0.099

85.0 (0.001)

0.127

<  60.0

0.82 (0.56 to 1.09)

< 0.001

84.9 (< 0.001)

Hypertension (%)

≥ 80.0

0.74 (−0.14 to 1.61)

0.099

85.0 (0.001)

0.127

<  80.0

0.82 (0.56 to 1.09)

< 0.001

84.9 (< 0.001)

Dose of paclitaxel

    

3.0 μg/mm2

0.73 (0.30 to 1.17)

0.001

88.6 (< 0.001)

0.032

3.5 μg/mm2

0.74 (0.52 to 0.95)

< 0.001

17.9 (0.296)

LLL at 6 months

Mean age (years)

≥ 70.0

0.08 (−0.61 to 0.78)

0.815

94.8 (< 0.001)

< 0.001

<  70.0

−0.83 (−1.14 to − 0.52)

< 0001

90.3 (< 0.001)

Smoker (%)

≥ 50.0

−0.37 (− 1.10 to 0.36)

0.320

95.4 (< 0.001)

< 0.001

<  50.0

−0.75 (−1.08 to − 0.41)

< 0.001

93.2 (< 0.001)

DM percent (%)

≥ 50.0

−0.55 (−1.64 to 0.55)

0.329

96.7 (< 0.001)

< 0.001

<  50.0

−0.57 (−1.14 to − 0.00)

0.049

99.0 (< 0.001)

Hyperlipidemia (%)

≥ 60.0

−0.72 (−1.37 to − 0.07)

0.031

86.1 (< 0.001)

< 0.001

<  60.0

−0.44 (−1.12 to 0.24)

0.201

99.4 (< 0.001)

Hypertension (%)

≥ 80.0

−0.80 (−1.76 to 016)

0.102

90.7 (< 0.001)

< 0.001

<  80.0

−0.46 (−1.08 to 0.16)

0.148

99.3 (< 0.001)

Dose of paclitaxel

    

3.0 μg/mm2

−0.59 (−0.87 to − 0.31)

< 0.001

90.5 (< 0.001)

< 0.001

3.5 μg/mm2

− 0.51 (−1.99 to 0.97)

0.500

96.0 (< 0.001)

Primary patency at 12 months

Mean age (years)

≥ 70.0

–

–

–

–

<  70.0

1.51 (1.25–1.83)

< 0.001

67.8 (0.008)

Smoker (%)

≥ 50.0

1.37 (1.15–1.63)

< 0.001

–

0.445

<  50.0

1.58 (1.22–2.03)

< 0.001

73.3 (0.005)

DM (%)

≥ 50.0

2.26 (1.65–3.09)

< 0.001

–

0.003

<  50.0

1.38 (1.20–1.59)

< 0.001

39.5 (0.158)

Hyperlipidemia (%)

≥ 60.0

1.36 (1.22–1.52)

< 0.001

12.7 (0.329)

0.001

<  60.0

2.34 (1.74–3.15)

< 0.001

0.0 (0.506)

Hypertension (%)

≥ 80.0

1.35 (1.14–1.61)

0.001

41.8 (0.180)

0.254

<  80.0

1.92 (1.18–3.11)

0.008

81.5 (0.004)

Dose of paclitaxel

    

2.0 μg/mm2

1.29 (1.15–1.46)

< 0.001

0.0 (0.696)

0.001

3.0 μg/mm2

2.34 (1.74–3.15)

< 0.001

0.0 (0.506)

3.5 μg/mm2

1.57 (1.29–1.91)

< 0.001

–

Restenosis at 6 months

Mean age (years)

≥ 70.0

0.58 (0.28–1.19)

0.137

71.4 (0.015)

0.005

<  70.0

0.38 (0.29–0.49)

< 0.001

0.0 (0.850)

Smoker percent (%)

≥ 50.0

0.56 (0.31–0.99)

0.047

66.1 (0.019)

0.009

<  50.0

0.37 (0.28–0.49)

< 0.001

0.0 (0.770)

DM (%)

≥ 50.0

0.61 (0.27–1.40)

0.242

88.4 (< 0.001)

0.200

<  50.0

0.41 (0.29–0.56)

< 0.001

0.0 (0.973)

Hyperlipidemia (%)

≥ 60.0

0.58 (0.34–0.97)

0.038

64.5 (0.024)

0.008

<  60.0

0.36 (0.26–0.48)

< 0.001

0.0 (0.715)

Hypertension (%)

≥ 80.0

0.62 (0.35–1.09)

0.098

70.0 (0.019)

0.004

<  80.0

0.36 (0.27–0.48)

< 0.001

0.0 (0.849)

Dose of paclitaxel

    

3.0 μg/mm2

0.48 (0.29–0.81)

0.005

72.7 (0.003)

1.000

3.5 μg/mm2

0.48 (0.32–0.71)

< 0.001

0.0 (0.506)

TLR at 6 months

Mean age (years)

≥ 70.0

0.56 (0.31–1.00)

0.051

0.0 (0.522)

0.075

<  70.0

0.31 (0.18–0.52)

< 0.001

42.9 (0.105)

Smoker (%)

≥ 50.0

0.57 (0.33–0.98)

0.041

0.0 (0.720)

0.035

<  50.0

0.28 (0.16–0.50)

< 0.001

45.5 (0.102)

DM (%)

≥ 50.0

0.32 (0.08–1.36)

0.124

86.2 (0.007)

1.000

<  50.0

0.37 (0.24–0.56)

< 0.001

10.0 (0.353)

Hyperlipidemia (%)

≥ 60.0

0.49 (0.26–0.92)

0026

31.2 (0.213)

0.041

<  60.0

0.27 (0.17–0.45)

< 0.001

19.8 (0.289)

Hypertension (%)

≥ 80.0

0.46 (0.23–0.94)

0.033

46.5 (0.133)

0.062

<  80.0

0.28 (0.17–0.46)

< 0.001

14.9 (0.319)

Dose of paclitaxel

    

2.0 μg/mm2

0.57 (0.23–1.45)

0.241

–

0.039

3.0 μg/mm2

0.26 (0.15–0.45)

< 0.001

31.5 (0.199)

3.5 μg/mm2

0.56 (0.32–0.97)

0.037

0.0 (0.558)

TLR at 12 months

Mean age (years)

≥ 70.0

0.53 (0.21–1.35)

0.183

63.7 (0.064)

0.421

<  70.0

0.42 (0.29–1.60)

< 0.001

69.9 (< 0.001)

Smoker (%)

≥ 50.0

0.47 (0.31–0.72)

< 0.001

36.6 (0.163)

1.000

<  50.0

0.41 (0.25–0.67)

< 0.001

79.0 (< 0.001)

DM (%)

≥ 50.0

0.48 (0.18–1.30)

0.149

83.5 (0.002)

0.778

<  50.0

0.43 (0.30–0.61)

< 0.001

62.3 (0.005)

Hyperlipidemia (%)

≥ 60.0

0.47 (0.30–0.75)

0.001

69.5 (0.002)

1.000

<  60.0

0.38 (0.22–0.65)

< 0.001

70.1 (0.010)

Hypertension (%)

≥ 80.0

0.50 (0.28–0.89)

0.018

76.5 (0.001)

0.297

<  80.0

0.39 (0.26–0.58)

< 0.001

56.1 (0.034)

Dose of paclitaxel

    

2.0 μg/mm2

0.62 (0.43–0.88)

0.007

26.1 (0.255)

0.007

3.0 μg/mm2

0.44 (0.26–0.76)

0.003

74.7 (0.001)

3.5 μg/mm2

0.24 (0.13–0.42)

< 0.001

14.2 (0.312)

TLR at 24 months

Mean age (years)

≥ 70.0

–

–

–

–

<  70.0

0.42 (0.30–0.58)

< 0.001

35.6 (0.169)

Smoker (%)

≥ 50.0

0.45 (0.20–0.98)

0.045

–

1.000

<  50.0

0.41 (0.28–0.60)

< 0.001

48.6 (0100)

DM (%)

≥ 50.0

–

–

–

–

<  50.0

0.42 (0.30–0.58)

< 0.001

35.6 (0.169)

Hyperlipidemia (%)

≥ 60.0

0.43 (0.28–0.68)

< 0.001

51.9 (0.100)

0.624

<  60.0

0.38 (0.22–0.65)

< 0.001

22.2 (0.257)

Hypertension (%)

≥ 80.0

0.43 (0.28–0.68)

< 0.001

51.9 (0.100)

0.624

<  80.0

0.38 (0.22–0.65)

< 0.001

22.2 (0.257)

Dose of paclitaxel

    

2.0 μg/mm2

0.73 (0.44–1.22)

0.233

–

0.059

3.0 μg/mm2

0.35 (0.24–0.52)

< 0.001

0.0 (0.401)

3.5 μg/mm2

0.37 (0.24–0.57)

< 0.001

0.0 (0.593)

All-cause mortality at 6 months

Mean age (years)

≥ 70.0

0.65 (0.18–2.29)

0.499

0.0 (0.567)

0.481

<  70.0

1.26 (0.34–4.69)

0.732

0.0 (0.517)

Smoker (%)

≥ 50.0

0.81 (0.25–2.61)

0.719

0.0 (0.577)

0.797

<  50.0

1.03 (0.24–4.39)

0.963

0.0 (0.393)

DM percent (%)

≥ 50.0

1.04 (0.22–4.91)

0.962

–

0.803

<  50.0

0.82 (0.27–2.53)

0.732

0.0 (0.571)

Hyperlipidemia (%)

≥ 60.0

0.94 (0.34–2.56)

0.900

0.0 (0.655)

0.804

<  60.0

0.71 (0.05–9.49)

0.797

28.9 (0.236)

Hypertension (%)

≥ 80.0

1.05 (0.37–3.03)

0.924

0.0 (0.576)

0.536

<  80.0

0.05 (0.09–3.31)

0.513

0.0 (0.462)

Dose of paclitaxel

    

2.0 μg/mm2

0.32 (0.03–2.96)

0.315

–

0.564

3.0 μg/mm2

1.44 (0.28–7.30)

0.663

0.0 (0.567)

3.5 μg/mm2

0.93 (0.26–3.30)

0.910

0.0 (0.443)

All-cause mortality at 12 months

Mean age (years)

≥ 70.0

0.54 (0.10–2.93)

0.474

30.4 (0.238)

0.815

<  70.0

0.94 (0.47–1.89)

0.860

0.0 (0.771)

Smoker (%)

≥ 50.0

0.83 (0.28–2.46)

0.741

7.1 (0.357)

1.000

<  50.0

0.88 (0.41–1.91)

0.746

0.0 (0.663)

DM (%)

≥ 50.0

1.13 (0.42–3.02)

0.806

0.0 (0.749)

0503

<  50.0

0.74 (0.33–1.63)

0.450

0.0 (0.488)

Hyperlipidemia (%)

≥ 60.0

0.94 (0.47–1.92)

0.873

0.0 (0.627)

0.686

<  60.0

0.67 (0.19–2.42)

0.546

0.0 (0.401)

Hypertension (%)

≥ 80.0

1.04 (0.50–2.14)

0.926

0.0 (0.663)

0.403

<  80.0

0.56 (0.17–1.81)

0.332

0.0 (0.500)

Dose of paclitaxel

    

2.0 μg/mm2

0.82 (0.35–1.88)

0.632

0.0 (0.698)

0.973

3.0 μg/mm2

0.98 (0.35–2.73)

0.965

0.0 (0.575)

3.5 μg/mm2

0.83 (0.03–24.78)

0.915

63.0 (0.100)

Major adverse events at 12 months

Mean age (years)

≥ 70.0

0.52 (0.20–1.36)

0.183

71.9 (0.029)

0.196

<  70.0

0.44 (0.29–0.66)

< 0.001

0.0 (0.694)

Smoker (%)

≥ 50.0

0.49 (0.32–0.76)

0.001

47.5 (0.090)

–

<  50.0

–

–

–

DM (%)

≥ 50.0

0.75 (0.38–1.46)

0.400

59.6 (0.116)

0.018

<  50.0

0.37 (0.24–0.57)

< 0.001

0.0 (0.685)

Hyperlipidemia (%)

≥ 60.0

0.59 (0.36–0.95)

0.031

46.2 (0.134)

0.083

<  60.0

0.33 (0.17–0.62)

0.001

0.0 (0.333)

Hypertension (%)

≥ 80.0

0.75 (0.38–1.46)

0.400

59.6 (0.116)

0.018

<  80.0

0.37 (0.24–0.57)

< 0.001

0.0 (0.685)

Dose of paclitaxel

    

2.0 μg/mm2

0.45 (0.28–0.74)

0.001

0.0 (0.418)

0.046

3.0 μg/mm2

0.79 (0.39–1.60)

0.514

43.5 (0.184)

3.5 μg/mm2

0.33 (0.17–0.62)

0.001

0.0 (0.333)

Amputation at 12 months

Mean age (years)

≥ 70.0

0.56 (0.05–5.91)

0.632

–

0.857

<  70.0

0.72 (0.20–2.61)

0.616

0.0 (0.802)

Smoker (%)

≥ 50.0

0.50 (0.12–2.11)

0.348

0.0 (0.855)

0.506

<  50.0

1.11 (0.18–6.99)

0.910

0.0 (0.633)

DM (%)

≥ 50.0

0.47 (0.07–3.09)

0.429

0.0 (0.792)

0.627

<  50.0

0.84 (0.20–3.43)

0.805

0.0 (0.714)

Hyperlipidemia (%)

≥ 60.0

1.08 (0.25–4.58)

0.922

0.0 (0.877)

0.321

<  60.0

0.33 (0.05–2.03)

0.232

0.0 (0.996)

Hypertension (%)

≥ 80.0

1.10 (0.22–5.60)

0.907

0.0 (0.712)

0.419

<  80.0

0.43 (0.09–2.08)

0.296

0.0 (0.845)

Dose of paclitaxel

    

2.0 μg/mm2

1.60 (0.25–10.06)

0.617

0.0 (0.899)

0.500

3.0 μg/mm2

0.47 (0.07–3.09)

0.429

0.0 (0.792)

3.5 μg/mm2

0.33 (0.04–2.99)

0.326

–