Table 3 Reactome pathway enrichment analysis of DEGs
From: Identification of key genes in atrial fibrillation using bioinformatics analysis
Reactome pathway | gene number (102) | fold Enrichment | raw P-value | FDR |
|---|---|---|---|---|
R-HSA-1474244: Extracellular matrix organization | 14 | 9.64 | 3.45E-10 | 7.55 E-07 |
R-HSA-1474290: Collagen formation | 8 | 18.5 | 2.29E-08 | 2.51 E-05 |
R-HSA-1650814: Collagen biosynthesis and modifying enzymes | 7 | 21.51 | 6.92 E-08 | 5.05 E-05 |
R-HSA-3000178: ECM proteoglycans | 7 | 18.96 | 1.54 E-07 | 8.44 E-05 |
R-HSA-2022090: Assembly of collagen fibrils and other multimeric structures | 6 | 20.58 | 7.91 E-07 | 3.47 E-04 |
R-HSA-8948216: Collagen chain trimerization | 5 | 23.39 | 3.85 E-06 | 1.41 E-03 |
R-HSA-186797: Signaling by PDGF | 5 | 18.71 | 1.06 E-05 | 3.31 E-03 |
R-HSA-381426: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | 6 | 9.96 | 4.05 E-05 | 1.11 E-02 |
R-HSA-216083: Integrin cell surface interactions | 5 | 12.25 | 7.20 E-05 | 1.75 E-02 |
R-HSA-2243919: Crosslinking of collagen fibrils | 3 | 34.31 | 1.37 E-04 | 3.00 E-02 |
R-HSA-8957275: Post-translational protein phosphorylation | 5 | 9.62 | 2.13 E-04 | 4.25 E-02 |