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Table 2 Odds ratios with 95% confidence intervals (95%CI) of having detectable urinary IgM excretion compared to not detectable, and the odds of microalbuminuria, high or low normoalbuminuria compared to not detectable urinary albumin excretion. Analyses were adjusted for age, sex, BMI, eGFR, current smoking and antihypertensive treatment. High normoalbuminuria was defined as ACR 1.5–2.9 mg/mmol and low normoalbuminuria was defined as ACR 0.1–1.4 mg/mmol

From: Patterns of urinary albumin and IgM associate with markers of vascular ageing in young to middle-aged individuals in the Malmö offspring study

  Urinary IgM excretion Urinary albumin excretion
Urinary IgM ≥ 10 ng/L
(n = 76) 		U-ACR ≥ 3.0 mg/mmol
(n = 27) 		U-ACR 1.5–2.9 mg/mmol
(n = 40) 		U-ACR 0.1–1.4 mg/mmol
(n = 624)
OR (95% CI) p OR (95% CI) p OR (95% CI) p OR (95% CI) p
Systolic BP 1.021 (1.003–1.039) 0.025 1.064 (1.033–1.097) < 0.001 1.050 (1.025–1.075) < 0.001 1.026 (1.017–1.036) < 0.001
Diastolic BP 1.029 (1.000–1.060) 0.050 1.095 (1.047–1.145) < 0.001 1.078 (1.038–1.119) < 0.001 1.041 (1.026–1.056) < 0.001
24-h mean SBP 1.023 (0.995–1.051) 0.114 1.077 (1.033–1.122) < 0.001 1.083 (1.044–1.124) < 0.001 1.026 (1.012–1.041) < 0.001
24-h mean DBP 1.025 (0.986–1.064) 0.210 1.097 (1.035–1.163) 0.002 1.090 (1.038–1.145) 0.001 1.026 (1.008–1.046) 0.006
24-h mean central systolic BP 1.005 (0.981–1.029) 0.703 1.063 (1.019–1.108) 0.005 1.062 (1.022–1.104) 0.002 1.006 (0.996–1.016) 0.277
24-h mean aortic c-f PWV 0.968 (0.744–1.259) 0.810 1.887 (1.114–3.197) 0.018 2.120 (1.352–3.323) 0.001 1.119 (0.983–1.274) 0.088
Daytime aortic c-f PWV 0.954 (0.745–1.221) 0.706 1.860 (1.080–3.205) 0.025 2.066 (1.309–3.260) 0.002 1.104 (0.975–1.251 0.120
Nighttime aortic c-f PWV 1.096 (0.871–1.379) 0.434 1.838 (1.131–2.986) 0.014 2.010 (1.320–3.063) 0.001 1.044 (0.963–1.131) 0.293
RHI 0.822 (0.493–1.371) 0.453 1.582 (0.653–3.833) 0.310 1.626 (0.853–3.102) 0.140 1.242 (0.982–1.572) 0.071
ABI dx 0.026 (0.002–0.381) 0.008 0.038 (0.000–3.372) 0.153 3.936 (0.128–121.26) 0.433 1.296 (0.382–4.4059 0.677
ABI sin 0.040 (0.003–0.496) 0.012 0.142 (0.003–7.674) 0.338 3.571 (0.094–135.00) 0.492 2.312 (0.665–8.043) 0.188
Number of carotid plaques dx 1.040 (0.669–1.617 0.863 1.608 (0.909–2.843) 0.102 1.812 (1.086–3.023) 0.023 1.001 (0.811–1.235) 0.995
Number of carotid plaques sin 1.065 (0.696–1.631) 0.770 1.804 (1.090–2.986) 0.022 1.391 (0.846–2.287) 0.194 1.057 (0.871–1.283) 0.573
  1. OR odds ratio, CI confidence interval, BP blood pressure, SBP systolic blood pressure, DBP diastolic blood pressure, RHI reactive hyperemia index, ABI ankle-brachial-index, ACR albumin creatinine ratio, BMI body mass index, eGFR estimated glomerular filtration rate, c-f PWV carotid-femoral pulse wave velocity
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BMC Cardiovascular Disorders

ISSN: 1471-2261

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