Skip to main content

Table 5 Association between clinical characteristics and the risk of all-cause death during follow-up analyzed by univariate and multivariate Cox proportional hazard model

From: Soluble neprilysin and long-term clinical outcomes in patients with coronary artery disease undergoing percutaneous coronary intervention: a retrospective cohort study

 

Univariate

Multivariate

HR (95% CI)

P value

HR (95% CI)

P value

Age

1.110 (1.075–1.146)

< 0.001

1.077 (1.027–1.130)

0.002

Female

1.748 (0.991–3.085)

0.054

1.133 (0.594–2.160)

0.705

Body mass index

0.917 (0.880–0.956)

< 0.001

1.037 (0.938–1.147)

0.473

Hypertension

1.885 (0.913–3.891)

0.087

1.099 (0.465–2.600)

0.830

Diabetes mellitus

1.414 (0.802–2.495)

0.232

  

Dyslipidemia

1.008 (0.547–1.856)

0.980

  

Smoking

0.487 (0.228–1.040)

0.063

1.234 (0.523–2.915)

0.631

Family history of CAD

0.527 (0.128–2.171)

0.375

  

Chronic kidney disease

2.472 (0.979–6.243)

0.055

0.957 (0.303–3.018)

0.940

Prior stroke

1.436 (0.644–3.200)

0.377

  

Acute myocardial infarction

4.320 (2.153–8.671)

< 0.001

3.191 (1.502–6.776)

0.003

Left ventricular ejection fraction

0.947 (0.929–0.965)

< 0.001

0.967 (0.942–0.994)

0.015

eGFR

0.960 (0.948–0.973)

< 0.001

0.983 (0.960–1.007)

0.173

NT-proBNP

1.000 (1.000–1.000)

< 0.001

1.000 (1.000–1.000)

0.420

Multivessel disease

1.009 (0.548–1.857)

0.978

  

Number of total stents

0.992 (0.764–1.290)

0.954

  

Mean diameter of stents

0.745 (0.363–1.528)

0.421

  

Total length of stents

1.006 (0.998–1.013)

0.168

  

Neprilysin > 76.0 pg/ml

1.437 (0.810–2.552)

0.215

1.558 (0.848–2.863)

0.153

  1. HR indicates hazard ratio, CI confidence interval, CAD coronary artery disease, eGFR estimated glomerular filtration rate, NT-proBNP N-terminal pro-B-type natriuretic peptide