Interaction between lipoprotein (a) levels and body mass index in first incident acute myocardial infarction

Table 2 Odds ratios of first incident AMI for elevated Lp(a) and BMI

Lp(a)	BMI < 24			BMI ≥ 24			^bORs(95% CI) for higher BMI within strata of Lp(a)
Lp(a)	N(ca/co)	Crude ^aOR (95% CI)	^aOR (95% CI)	N(ca/co)	Crude ^aOR (95% CI)	^aOR (95% CI)	^bORs(95% CI) for higher BMI within strata of Lp(a)
Q1	177/61	1.0	1.0	254/166	1.90 (1.34–2.69)	2.27 (1.46–3.52)	2.27 (1.46–3.52)
Q2	150/82	1.59 (1.07–2.36)	1.79 (1.11–2.90)	204/195	2.77 (1.95–3.94)	2.86 (1.85–4.40)	1.71 (1.14–2.56)
Q3	161/90	1.62 (1.10–2.39)	1.65 (1.05–2.60)	189/212	3.25 (2.29–4.62)	3.30 (2.14–5.11)	1.93 (1.32–2.82)
Q4	137/103	2.18 (1.48–3.21)	1.96 (1.20–3.20)	154/237	4.46 (3.13–6.37)	4.43 (2.76–7.09)	2.56 (1.68–3.91)
Q5	137/137	2.90 (1.99–4.22)	2.34 (1.47–3.71)	128/239	5.42 (3.77–7.79)	5.98 (3.72–9.60)	2.43 (1.63–3.62)
^cOR(95% CI) for higherLp(a) within strata of BMI			1.79 (1.11,2.90)			1.26 (0.91–1.75)
			1.65 (1.05,2.60)			1.38 (0.99–1.93)
			1.96 (1.20,3.20)			1.68 (1.18–2.39)
			2.34 (1.47–3.71)			2.23 (1.56–3.17)

Note: Q1-Q5: quintile of Lp(a), Q1: ≤34 mg/L, Q2: ≤65 mg/L, Q3: ≤118 mg/L, Q4: ≤246.9 mg/L, Q5: ≤2138 mg/L. a, comparing with BMI < 24 kg/m2 and Lp(a) ≤ 34 mg/L; b, OR of BMI ≥ 24 kg/m2 comparing with BMI < 24 kg/m2 in the same Lp(a) level; c, OR of Lp(a) in Q2-Q5 comparing with Q1 in the same BMI level. Adjustment: age, sex, smoking, drinking, diabetes mellitus, primary hypertension, high density lipoprotein cholesterol, low density lipoprotein cholesterol, triglyceride, albumin, creatinine. Abbreviations: Lp(a) lipoprotein(a); BMI body mass index; AMI;acute myocardial infarction; OR odds ratio; CI confidence interval; ca/co cases/controls

ISSN: 1471-2261