Fig. 1

Diagram illustrating hierarchical clustering into 2, 3, 4 or 5 clusters. The original population of 161 asymptomatic diastolic dysfunction patients was repeatedly subdivided into smaller clusters based on phenotypic similarities with numbers in bold indicating the number of patients assigned to each cluster. Numbers in parentheses indicate the percentage of patients within the clusters who progress from diastolic dysfunction to HFpEF. Chi-squared p values indicate the probability of whether the frequency of HFpEF is the same among the clusters