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Table 6 Interaction analysis (MDR) among CVD cases and controls

From: Association of ESR1 (rs2234693 and rs9340799), CETP (rs708272), MTHFR (rs1801133 and rs2274976) and MS (rs185087) polymorphisms with Coronary Artery Disease (CAD)

Interaction Model

TBA

CVC

p-value

Gene-Gene Interaction

SNP 6

0.52

8/10

0.001

SNP 2, 5

0.5948

10/10

< 0.0001*

SNP 2, 3, 5

0.6574

9/10

< 0.0001*

SNP 1, 2, 3, 5

0.6563

6/10

< 0.0001*

SNP 1, 2, 3, 5, 6

0.7111

9/10

< 0.0001*

SNP 1, 2, 3, 4, 5, 6

0.7186

10/10

< 0.0001*

Gene-Environment Interaction

A1

0.6363

10/10

< 0.0001*

SNP 5, A1

0.6347

6/10

< 0.0001*

SNP 2, 5, A1

0.705

10/10

< 0.0001*

SNP 1, 2, 5, A1

0.7153

10/10

< 0.0001*

SNP 1, 2, 3, 5, A1

0.7103

7/10

< 0.0001*

SNP 1, 2, 3, 5, 6, A1

0.7301

9/10

< 0.0001*

SNP 1, 2, 3, 5, 6, A1, A2

0.7379

7/10

< 0.0001*

SNP 1, 2, 3, 4, 5, 6, A1, A2

0.7403

10/10

< 0.0001*

  1. * Significant values. A1: Smoking; A2: Physical Inactivity