Association of ESR1 (rs2234693 and rs9340799), CETP (rs708272), MTHFR (rs1801133 and rs2274976) and MS (rs185087) polymorphisms with Coronary Artery Disease (CAD)

Table 5 Association of ESR1 and MTHFR gene haplotypes with risk of CAD

Variant ESR1 IVS1–397 T > C/ -351 A > G	Haplotype frequencies		OR (95% CI)	p-value^†
Variant ESR1 IVS1–397 T > C/ -351 A > G	Patients (n = 400)	Controls (n = 400)	OR (95% CI)	p-value^†
C-A	0.068	0.258	0.210 [0.153–0.289]	2.22e-016*
C-G	0.278	0.073	4.906 [3.604–6.678]	5.00e-015*
T-A	0.439	0.327	1.616 [1.318–1.980]	3.61e-006*
T-G	0.215	0.342	0.525 [0.420–0.656]	1.27e-008*
Variant MTHFR C677T/ G1793A
C-A	0.109	0.087	1.29 [0.93–1.79]	0.1
C-G	0.833	0.901	0.57 [0.42–0.77]	0.0002
T-G	0.050	0.011	4.71 [2.27–9.76]	5.18e-006*
T-A	0.007	0.000	–	–

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