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Table 3 Showing genotypic and allelic distribution of selected gene polymorphisms among cases and controls

From: Association of ESR1 (rs2234693 and rs9340799), CETP (rs708272), MTHFR (rs1801133 and rs2274976) and MS (rs185087) polymorphisms with Coronary Artery Disease (CAD)

Genotypic/Allelic frequencies

Cases (N = 400)

Controls (N = 400)

ESR1IVS1–397 T/C

 TT

168 (42%)

175 (43.75%)

 TC

187 (46.75%)

185 (46.25%)

 CC

45 (11.25%)

40 (10%)

 T (Major)

0.65

0.67

 C (Minor)

0.35

0.33

χ2

0.65

0.5

 p-value

0.77

0.4

ESR1- IVS1–351 A/G

 AA

105 (26.25%)

133 (33.25%)

 AG

196 (49%)

202 (50.5%)

 GG

99 (24.75%)

65 (16.25%)

 A (Major)

0.51

0.59

 G (Minor)

0.49

0.42

χ2

0.16

0.7

 p-value

0.64

0.4

CETP-(C277T) (TaqIB)

 B2B2

104 (26%)

116 (29%)

 B1B2

215 (53.75%)

212 (53%)

 B1B1

81 (20.25%)

72 (18%)

 B2 (Major)

0.53

0.56

 B1 (Minor)

0.47

0.45

χ2

2.47

0.1

 p-value

2.13

0.1

MTHFRC677T

 CC

358 (89.5%)

391 (97.75%)

 CT

38 (9.5%)

9 (2.25%)

 TT

4 (1%)

0

 C (Major)

0.94

0.98

 T (Minor)

0.06

0.02

χ2

6.1

0.01*

 p-value

0.05

0.82

MTHFRG1793A

 GG

311 (77.75%)

330 (82.5%)

 GA

85 (21.25%)

70 (17.5%)

 AA

4 (1%)

0

 G (Major)

0.88

0.9

 A (Minor)

0.12

0.1

χ2

0.47

0.06

 p-value

3.68

0.5

MSA2756G

 AA

251 (62.75%)

294 (73.5%)

 AG

139 (34.75%)

103 (25.75%)

 GG

10 (2.5%)

3 (0.75%)

 A (Major)

0.8

0.86

 G (Minor)

0.2

0.14

χ2

3.32

0.1

 p-value

3.54

0.06

  1. * Significant values