TY - JOUR AU - Gao, Side AU - Hua, Bing AU - Liu, Qingbo AU - Liu, Huirong AU - Li, Weiping AU - Li, Hongwei PY - 2020 DA - 2020/07/14 TI - Role of peroxisome proliferators-activated receptor-gamma in advanced glycation end product-mediated functional loss of voltage-gated potassium channel in rat coronary arteries JO - BMC Cardiovascular Disorders SP - 337 VL - 20 IS - 1 AB - High blood glucose impairs voltage-gated K+ (Kv) channel-mediated vasodilation in rat coronary artery smooth muscle cells (CSMCs) via oxidative stress. Advanced glycation end product (AGE) and receptor for AGE (RAGE) axis has been found to impair coronary dilation by reducing Kv channel activity in diabetic rat small coronary arteries (RSCAs). However, its underlying mechanism remain unclear. Here, we used isolated arteries and primary CSMCs to investigate the effect of AGE incubation on Kv channel-mediated coronary dilation and the possible involvement of peroxisome proliferators-activated receptor (PPAR) -γ pathway. SN - 1471-2261 UR - https://doi.org/10.1186/s12872-020-01613-y DO - 10.1186/s12872-020-01613-y ID - Gao2020 ER -