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Table 3 Independent predictors of major adverse outcomes by multivariable Cox regression analysis in SCAD+AF group and ACS + AF group

From: Antithrombotic therapy in coronary artery disease patients with atrial fibrillation

 

SCAD + AF

ACS + AF

OR (95% CI)

P-value

OR (95% CI)

P-value

Ischemic stroke

Age ≥ 65

1.03 (1.01–1.06)

0.007*

1.44 (1.06–1.98)

0.006*

Female

1.35 (0.85–1.99)

0.179

1.21 (0.93–1.60)

0.117

Hypertension

1.33 (1.04–1.72)

0.014*

1.50 (1.22–1.83)

0.020*

Heart failure

0.99 (0.94–1.03)

0.225

1.26 (0.89–1.78)

0.193

Diabetes mellitus

0.62 (0.27–1.46)

0.214

0.92 (0.36–2.27)

0.890

Previous stroke

1.39 (1.12–2.17)

0.009*

1.25 (1.04–1.56)

0.031*

Previous bleeding

1.68 (0.77–3.68)

0.180

1.16 (0.57–2.42)

0.713

Coronary stent

0.81 (0.31–2.26)

0.700

0.78 (0.37–1.53)

0.440

OAC

0.33 (0.25–0.46)

0.016*

0.54 (0.30–0.93)

0.005*

APT

0.72 (0.42–1.10)

0.113

0.88 (0.44–1.65)

0.637

Bleeding

Age ≥ 65

1.29 (0.51–3.35)

0.587

1.85 (1.28–2.66)

0.020*

Female

1.30 (0.57–2.93)

0.508

0.90 (0.76–1.04)

0.162

Hypertension

1.10 (0.74–1.63)

0.482

1.14 (0.95–1.33)

0.148

Heart failure

1.04 (0.75–1.45)

0.912

0.67 (0.39–1.13)

0.134

Diabetes mellitus

0.95 (0.77–1.16)

0.872

1.05 (0.87–1.23)

0.960

Previous stroke

1.17 (0.42–3.27)

0.353

1.55 (0.70–3.45)

0.172

Previous bleeding

1.85 (1.12–3.07)

0.001*

1.78 (1.33–2.39)

0.006*

Coronary stent

0.67 (0.41–1.11)

0.621

1.34 (0.67–2.70)

0.316

OAC

1.17 (0.56–2.25)

0.658

2.28 (0.58–3.91)

0.243

APT

1.32 (0.86–2.01)

0.137

2.18 (0.71–6.73)

0.171

MI

Age ≥ 65

1.65 (0.73–3.74)

0.240

1.16 (0.56–2.13)

0.723

Female

1.55 (0.83–2.91)

0.133

0.93 (0.59–1.46)

0.738

Hypertension

1.34 (0.82–2.17)

0.224

2.29 (0.71–7.40)

0.166

Heart failure

0.79 (0.40–1.62)

0.557

0.99 (0.91–2.08)

0.787

Diabetes mellitus

1.26 (0.60–3.31)

0.453

2.23 (1.75–2.83)

0.001*

Previous stroke

1.42 (0.82–2.60)

0.178

1.71 (0.69–4.27)

0.248

Previous bleeding

1.28 (0.70–2.64)

0.430

1.51 (0.96–2.37)

0.308

Coronary stent

1.03 (0.89–1.17)

0.713

0.95 (0.81–1.10)

0.558

OAC

0.90 (0.57–1.38)

0.628

1.30 (0.65–2.58)

0.639

APT

0.71 (0.58–0.86)

0.004*

0.66 (0.56–0.79)

< 0.001*

All-cause death

Age ≥ 65

1.67 (1.37–2.02)

0.005*

1.47 (1.21–1.79)

0.001*

Female

0.85 (0.57–1.28)

0.470

0.93 (0.66–1.37)

0.750

Hypertension

1.01 (0.96–1.04)

0.615

1.12 (0.93–1.31)

0.087

Heart failure

2.81 (1.82–4.34)

0.028*

3.02 (1.61–5.68)

0.003*

Diabetes mellitus

0.84 (0.52–1.19)

0.390

0.96 (0.67–1.38)

0.839

Previous stroke

1.11 (0.87–1.38)

0.380

1.40 (0.55–3.23)

0.560

Previous bleeding

2.07 (0.72–5.71)

0.184

1.28 (0.85–1.91)

0.215

Coronary stent

0.76 (0.54–1.09)

0.119

0.70 (0.42–1.17)

0.148

OAC

0.32 (0.18–0.57)

< 0.001*

0.47 (0.28–0.77)

0.009*

APT

0.71 (0.54–0.95)

0.015*

0.57 (0.42–0.75)

< 0.001*

  1. *Statically significant at p < 0.05. Abbreviations: OR odds ratio, CI confidence interval, SCAD stable coronary artery disease, ACS acute coronary syndrome, AF atrial fibrillation, MI myocardial infarction, OAC oral anticoagulant, APT antiplatelet therapy
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