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Table 1 Baseline characteristics according to high thrombotic risk features

From: Contribution of ESC DAPT guideline-endorsed high thrombotic risk features to long-term clinical outcomes among patients with and without high bleeding risk after PCI

 

HTR features (n = 4430)

Non-HTR features (n = 5018)

P value

Age, yrs

59.21 ± 10.27

57.64 ± 10.19

< 0.001

 Age ≥ 75 years

338 (7.6)

293 (5.1)

< 0.001

Male

3396 (76.7)

4445 (77.5)

0.329

Body mass index, kg/m2

26.04 ± 3.17

25.84 ± 3.19

0.002

Hypertension

3027 (68.3)

3514 (61.3)

< 0.001

Diabetes mellitus

2073 (46.8)

969 (16.9)

< 0.001

Hyperlipidemia

3042 (68.7)

3795 (66.1)

0.007

eGFR

92.48 ± 20.66

97.06 ± 16.37

< 0.001

 Moderate CKD (eGFR ≥ 30, < 60 ml/min/1.73m2)

353 (8.0)

0 (0.0)

< 0.001

 Severe CKD (eGFR < 30 ml/min/1.73m2)

7 (0.2)

0 (0.0)

0.003

Current smoker

2509 (56.6)

3305 (57.6)

0.326

Previous myocardial infarction

940 (21.2)

980 (17.1)

< 0.001

Previous PCI

1007 (22.7)

1414 (24.6)

0.025

Previous CABG

219 (4.9)

184 (3.2)

< 0.001

Previous stroke

553 (12.5)

527 (9.2)

< 0.001

Peripheral arterial disease

147 (3.3)

120 (2.1)

< 0.001

LVEF, %

62.37 ± 7.54

63.20 ± 6.97

<  0.001

Indication

Stable CAD

1905 (43.0)

2168 (37.8)

< 0.001

ACS

2525 (57.0)

3569 (62.2)

< 0.001

 UA/NSTEMI

1980 (44.7)

2776 (48.4)

< 0.001

 STEMI

545 (12.3)

793 (13.8)

0.025

Hemoglobin, g/dL

14.22 ± 1.57

14.36 ± 1.50

< 0.001

 Severe anemia (Hb<11 g/dL)

98 (2.2)

80 (1.4)

0.002

 Mild anemia (Hb: 11.0-12.9 g/dL for males or 11.0-11.9 g/dL for females)

461 (10.4)

479 (8.3)

< 0.001

Platelet count, 109/L

204.63 ± 54.15

206.50 ± 56.27

0.090

 Platelet<100×109/L

44 (1.0)

49 (0.9)

0.465

White blood cell count, 109/L

6.81 ± 1.64

6.69 ± 1.71

0.001

PARIS thrombotic risk score

2.83 ± 1.82

2.27 ± 1.52

< 0.001

PARIS bleeding risk score

3.86 ± 2.20

3.59 ± 1.97

< 0.001

PRECISE-DAPT score

11.54 ± 9.25

9.85 ± 7.77

< 0.001

Oral anticoagulation therapy

6 (0.1)

12 (0.2)

0.381

Duration of DAPT, days

576.49 ± 207.78

562.37 ± 208.25

0.001

  1. Values are mean ± SD for continuous variables, and n (%) for categorical variables. ACS acute coronary syndrome(s), CAD coronary artery disease, CKD chronic kidney disease, CABG coronary artery bypass grafting, DAPT dual antiplatelet therapy, HTR high thrombotic risk, LVEF left ventricular ejection fraction, MI myocardial infarction, NSTEMI non-ST-segment elevation myocardial infarction, PAD peripheral artery disease, PCI percutaneous coronary intervention, PARIS Patterns of Non-Adherence to Anti-Platelet Regimen in Stented Patients, STEMI ST-segment elevation myocardial infarction, UA unstable angina