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Table 5 Adjusted restricted mean survival time (RMST) of study participants according to JNC7 and the 2017 ACC/AHA guidelines; Tehran Lipid and Glucose Study (1999–2014)

From: Multi-state analysis of hypertension and mortality: application of semi-Markov model in a longitudinal cohort study

 

Difference of estimated RMST

SE

P-value

Difference of estimated RMST

SE

P-value

Multi-state model 1

Transition

According to JNC7

According to the 2017 ACC/AHA

CVD-free to non-fatal CVD

 Hypertensives

−0.71

0.14

< 0.001

− 0.5

0.14

< 0.001

CVD-free to CVD death

 Hypertensives

−0.71

0.14

< 0.001

−0.5

0.14

< 0.001

Non-fatal CVD to CVD death

 Hypertensives

−0.12

0.4

0.75

0.10

0.40

0.838

Multi-state model 2

CVD-free to non-fatal CVD

 Hypertensives

−0.71

0.14

< 0.001

− 0.54

0.14

< 0.001

CVD-free to all-cause death

 Hypertensives

−0.71

0.14

< 0.001

−0.54

0.14

< 0.001

Non-fatal CVD to all-cause death

 Hypertensives

−0.35

0.44

0.42

−0.30

0.44

0.567

  1. In multi-state model 1 transition 3 is CVD death, and in multi-state model 2 transition 3 is all-cause death
  2. SE: standard error; CVD: cardiovascular disease; JNC7: the Seventh Report of Joint National Committee;
  3. ACC/AHA: American College of Cardiology/American Heart Association
  4. Restricted mean survival times (RMST) were estimated using pseudo-value technique
  5. Estimated RMST were adjusted for age, sex, smoking, total cholesterol, prevalent diabetes and body mass index
  6. In multi-state model 1, patients with hypertension had the significantly shorter RMST, namely 0.71 in transitions 1 and 2, and 0.5 in transitions 1 and 2 according to JNC7 and the 2017 ACC/AHA guideline, respectively, than normotensive participants
  7. In multi-state model 2, patients with hypertension had the significantly shorter RMST, namely 0.71 years in transitions 1, 2 according to JNC7 guideline and 0.54 years in transitions 1, 2 according to the 2017 ACC/AHA guideline, than normotensive participants