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Table 4 RMST and RMTL stratified by transitions and hypertension status according to JNC7 and the 2017 ACC/AHA guidelines; Tehran Lipid and Glucose Study (1999–2014)

From: Multi-state analysis of hypertension and mortality: application of semi-Markov model in a longitudinal cohort study

 

Hypertension status

RMST Mean (CI)

RMST Difference (CI)

RMTL Mean (CI)

RMTL Ratios (CI)

RMST Mean (CI)

RMST Difference (CI)

RMTL Mean (CI)

RMTL Ratios (CI)

Multi-state model 1

Transition

 

According to JNC7

According to the 2017 ACC/AHA

CVD-free to non-fatal CVD

Normotensives

13.6 (13.4–13.7)

−0.9 (−1.1,− 0.6)*

1.4 (1.2–1.5)

1.6 (1.4–1.9)*

13.7 (13.4–13.9)

-0.6 (− 0.8,-0.3)*

1.3 (1.1–1.5)

1.4 (1.2, 1.7)*

Hypertensives

12.7 (12.5–13.0)

2.3 (1.9–2.4)

13.1 (12.9–13.2)

1.9 (1.7–2.1)

CVD-free to CVD death

Normotensives

14.7 (14.6–14.8)

−0.5 (−0.7,− 0.3)*

0.3 (0.1–0.4)

2.6 (2.1–4.2)*

14.7 (14.6–14.8)

-0.3 (− 0.4,− 0.1)*

0.3 (0.1–0.3)

2.0 (1.3, 3.1) †

Hypertensives

14.2 (14.1–14.3)

0.8 (0.6–0.9)

14.4 (14.3–14.5)

0.6 (0.4–0.6)

Non-fatal CVD to CVD death

Normotensives

10.6 (10.1–11.0)

−0.1 (− 0.7, 0.5)

1.4 (0.9–1.9)

1.1 (0.7–1.6)

10.6 (9.7–11.0)

-0.1 (− 0.5, 0.9)

1.4 (0.6–1.9)

1.1 (0.5, 1.4)

Hypertensives

10.5(10.0–10.9)

1.5 (1.1–1.9)

10.5(10.2–10.9)

1.5 (1.1–1.8)

Multi-state model 2

CVD-free to non-fatal CVD

Normotensives

13.6 (13.5–13.8)

− 0.9 (−1.1,− 0.6)*

1.4 (1.2–1.5)

1.6 (1.4–1.9)*

13.7 (13.5, 13.9)

-0.6 (− 0.8,-0.3)*

1.3 (1.1, 1.5)

1.4 (1.2, 1.7)*

Hypertensives

12.7 (12.5–13.0)

2.2 (1.9–2.4)

13.1 (12.9, 13.2)

1.9 (1.7, 2.1)

CVD-free to all-cause death

Normotensives

14.2 (14.1–14.3)

−0.7 (−0.9,-0.5)*

0.8 (0.6–0.8)

1.9 (1.5–2.3)*

14.2 (14.0, 14.3)

−0.4 (− 0.5,-0.1)†

0.8 (0.6, 0.9)

1.5 (1.1, 1.8)†

Hypertensives

13.5 (13.3–13.7)

1.5 (1.2–1.6)

13.8 (13.6, 13.9)

1.2 (1.0, 1.3)

Non-fatal CVD to all-cause death

Normotensives

9.7 (9.2–10.3)

−0.3 (−1.1, 0.3)

2.3 (1.7–2.8)

1.1 (0.8–1.5)

9.51 (8.7, 10.2)

0.01 (−0.8, 0.9)

2.47 (1.8, 3.4)

1.01 (0.9, 1.1)

Hypertensives

9.4 (8.8–9.8)

2.6 (2.1–3.1)

9.50 (9.1–10.0)

2.49 (2.0, 2.8)

  1. RMST: restricted mean survival time; RMTL: restricted mean time lost; In multi-state model 1 transition 3 is CVD death, and in multi-state model 2 transition 3 is all-cause death
  2. CI: confidence interval; CVD: cardiovascular disease; JNC7: the Seventh Report of Joint National Committee; ACC/AHA: American College of Cardiology/American Heart Association. RMST Difference: shows the difference between RMST of hypertensives and normotensives; RMTL Ratios: is the ratio of RMTL of hypertensives to RMTL of normotensives
  3. *P-value< 0.001;†P-value< 0.01
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BMC Cardiovascular Disorders

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