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Table 3 Estimation of Hazard ratios and confidence intervals of hypertension for non-fatal CVD and CVD death and all-cause death with and without CVD according to JNC7 and the 2017 ACC/AHA guidelines, Tehran Lipid and Glucose Study (1999–2014)

From: Multi-state analysis of hypertension and mortality: application of semi-Markov model in a longitudinal cohort study

 

Number of participants entered /number of events

Sex and age adjusted

HR (95% CI)

Confounders adjusted

HR (95% CI)

Number of participants entered /number of events

Sex and age adjusted

HR (95% CI)

Confounders adjusted

HR (95% CI)

Multi-state model 1

Transitions

According to JNC7

According to the 2017 ACC/AHA

CVD-free to non-fatal CVD

 Total

3002/601

  

3002/601

  

Normotensive

1701/283

Reference

Reference

942/143

Reference

Reference

Hypertensive

1301/318

1.64 (1.39–1.93)*

1.52 (1.28–1.81)*

2060/458

1.55 (1.28–1.87)*

1.48 (1.21–1.80)†

CVD-free to CVD death

 Total

3002/156

  

3002/156

  

Normotensive

1701/49

Reference

Reference

942/29

Reference

Reference

Hypertensive

1301/107

2.81 (1.99–3.97)*

2.96 (2.06–4.25)*

2060/127

1.92 (1.27–2.88)*

1.98 (1.30–3.04)†

Non-fatal CVD to CVD death

 Total

601/71

  

601/71

  

Normotensive

245/30

Reference

Reference

142/20

Reference

Reference

Hypertensive

356/41

1.02 (0.63–1.64)

1.06 (0.65–1.72)

459/51

0.79 (0.47–1.33)

0.85 (0.50–1.44)

Multi-state model 2

CVD-free to non-fatal CVD

 Total

3002/601

  

3002/601

  

 Normotensive

1701/283

Reference

Reference

942/143

Reference

Reference

 Hypertensive

1301/318

1.64 (1.39–1.93)*

1.52 (1.28–1.81)*

2060/458

1.55 (1.28–1.87)*

1.48 (1.21–1.80)*

CVD-free to all-cause death CVD-free to CVD death

 Total

3002/493

  

3002/493

  

 Normotensive

1701/208

Reference

Reference

942/122

Reference

Reference

 Hypertensive

1301/285

1.62 (1.31–2.00)*

1.64 (1.32–2.05)*

2060/371

1.30 (1.02–1.66)†

1.31 (1.01–1.69)†

Non-fatal CVD to all-cause death

 Total

601/126

  

601/126

  

 Normotensive

245/51

Reference

Reference

142/31

Reference

Reference

 Hypertensive

356/75

1.09 (0.76–1.56)

1.13 (0.78–1.63)

459/95

0.95 (0.63–1.43)

1.00 (0.66–1.51)

  1. In multi-state model 1 transition 3 is CVD death, and in multi-state model 2 transition 3 is all-cause death; Confounders included: age, sex, smoking, total cholesterol, prevalent diabetes and body mass index; CVD: cardiovascular disease; *P-value< 0.001;†P-value< 0.01
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BMC Cardiovascular Disorders

ISSN: 1471-2261

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