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Table 1 A Description of the Studies Included in the Meta-Analysis

From: The effect of milrinone on mortality in adult patients who underwent CABG surgery: a systematic review of randomized clinical trials with a meta-analysis and trial sequential analysis

First Author

Journal

Year

Procedures

Control

Inclusion Criteria

Exclusion Criteria

Primary Outcome

Secondary Outcome

Arbeus M [38]

Journal of Cardiothoracic and Vascular Anesthesia

2009

Elective CABG

Placebo

Stable angina,

LVEF (%) > 30%,

Sinus rhythm.

Unspecified

Graft flow

Unspecified

Couture P [39]

Canadian Journal of Anaesthesia

2007

Elective CABG

Placebo

Ischemic heart disease, LV diastolic dysfunction.

Mitral and aortic valvular disease,

Atrial fibrillation or pacemaker, Contraindication to TEE.

LV diastolic dysfunction

Unspecified

Doolan LA [40]

Journal of Cardiothoracic and Vascular Anesthesia

1997

Elective CABG and valvular surgery

Placebo

LVEF (%) ≤ 35%,

Mean PAP ≥ 20 mmHg.

Supraventricular tachyarrhythmias,

Platelet countless than 100 × 109/L (preoperative),

Significant primary hepatic or renal disease.

Success or failure in weaning from bypass.

Hemodynamic variables

Guo YJ [9]

Chinese Heart Journal

2014

Elective CABG

Placebo

CABG surgery,

LVEF (%) < 35%,

Emergency surgery,

Myocardial infarction,

Ventricular arrhythmias,

Requiring inotropic support.

Myocardial ischemia and/or MI incidence

Mean arterial pressure, Requirements for vasopressors, Death, Length of hospital stay, Serum potassium and creatinine Concentrations.

Hadadzadeh M [41]

Acta medica Iranica

2013

Elective CABG (off-pump)

Placebo

Severe myocardium dysfunction (LVEF (%) < 35%)

Emergency CABG,

Myocardial infarction,

Ventricular arrhythmias,

Requiring inotropic support.

Myocardial ischemia and/or MI incidence

Unspecified

Hamada Y [42]

Japanese circulation journal

1999

Elective CABG and valvular surgery

Standard treatment

Unspecified

Unspecified

Hemodynamic variables

Unspecified

Hayashida N [43]

Annals of Thoracic Surgery

1999

Elective CABG

Standard treatment

Isolated CABG surgery

Myocardial ischemia,

Acute myocardial infarction

Cytokine production

Unspecified

Jebeli M [44]

Cardiology Journal

2010

Elective CABG

Placebo

LVEF (%) < 35%,

Emergency CABG,

Myocardial infarction,

Ventricular arrhythmias,

Requiring inotropic support.

Myocardial ischemia and/or MI incidence

Cardiac enzyme levels,

Duration of inotropic support.

Jo HR [45]

Korean Journal of Anesthesiology

2010

Elective CABG (off-pump)

Placebo

CABG surgery, Normal LV function.

LVEF or RVEF (%) < 40%,

Valvular heart disease,

Severe cerebral or renal dysfunction, Emergency surgery.

Right ventricular function and early outcomes

Unspecified

Kwak YL [46]

European journal of cardio-thoracic surgery

2004

Elective CABG (off-pump)

Placebo

Unspecified

Renal or hepatic dysfunction, Thrombocytopenia,

Coagulopathy.

Cardiac Index

Unspecified

Lee JH [32]

Journal of korean medical science

2006

Elective CABG (off-pump)

Placebo

RVEF (%) < 35%

Hepatic or renal dysfunction, Thrombocytopenia or coagulopathy,

Supraventricular tachyarrhythmias,

Single coronary artery disease,

History of receiving inotropic agents.

Right ventricular function and early outcomes

Unspecified

Möllhoff T [47]

Anesthesiology

1999

Elective CABG

Placebo

Elective CABG

LVEF (%) < 50%,

Gastrointestinal disorders,

Diabetes

Splanchnic oxygenation,

Systemic inflammation, Subsequent acute-phase response.

Unspecified

Shi YF [48]

Journal of Thoracic and Cardiovascular Surgery

2006

Elective CABG

Placebo

Elective CABG

Had pacemaker or not in sinus rhythm

Biventricular filling properties

Unspecified

Song JW [49]

Korean Journal of Anesthesiology

2011

Elective CABG (off-pump)

Placebo

E/e’ value > 15

Concomitant systolic dysfunction,

Mitral regurgitation ≥ Grade 2,

Emergency operation.

Hemodynamics and short term outcomes

Unspecified

Yamaguchi A [50]

Annals Of Thoracic And Cardiovascular Surgery

2009

Elective CABG and valvular surgery

Standard treatment

Elective CABG concomitant LVR,

LV dysfunction (LVEF (%) < 30%),

LVESVI > 100 ml/m2

Unspecified

Left ventricular restoration

Unspecified

Yamaura K [51]

Journal of Cardiothoracic and Vascular Anesthesia

2001

Elective CABG

Standard treatment

Cardiac Surgery

Unspecified

Gastric intramucosal pH,

Systemic inflammation

Unspecified

  1. Abbreviations: CABG coronary artery bypass grafting, LVEF left ventricular ejection fraction, TEE transesophageal echocardiography, PAP pulmonary arterial pressure, AF atrial fibrillation, MI myocardial infarction, E/e’ the ratio of the early transmitral flow velocity to the early diastolic velocity of the mitral annulus, LVR left ventricular restoration, LVESVI left ventricular end-systolic volume index