Efficacy measure | Time point | CTD-PAH(N = 71) | IPAH/HPAH (N = 50) | Between-group difference$ |
---|---|---|---|---|
6MWT, m (LOCF) | Baseline | 366.4 (60.4) | 397.3 (48.1) | |
Change from baseline (Week 12) | 63.8 (57.4) | 45.5 (69.7) | −18.39 | |
p value | < 0.001* | < 0.001* | 0.115¥ | |
Change from baseline (Week 24) | 73.2 (84.6) | 62.2 (81.9) | −10.97 | |
p value | < 0.001* | < 0.001* | 0.478¥ | |
BDI score (LOCF) | Baseline | 2.7 (1.4) | 2.3 (1.5) | |
Change from baseline (Week 12) | −0.6 (1.1) | −0.2 (1.9) | 0.35 | |
p value | < 0.001§ | 0.427§ | 0.203¶ | |
Change from baseline (Week 24) | −0.4 (1.70) | −0.2 (1.96) | 0.19 | |
p value | 0.002§ | 0.138§ | 0.377¶ | |
NT-proBNP, ng/L (Observed data) | Baseline | 1837.5 (2209.6) | 1281.3 (1140.6) | |
Change from baseline (Week 12) | −1156.8 (1735.4) | −450.3 (699) | 706.49 | |
p value | < 0.001§ | < 0.001§ | 0.007¶ | |
Change from baseline (Week 24) | −1095.5 (1587.7) | − 396.6 (738.5) | 698.89 | |
p value | < 0.001§ | < 0.001§ | 0.011¶ |