Table 1 Baseline characteristics according to neprilysin levels
Overall (n = 68) | Neprilysin level ≤ 125 pg/mL (n = 38) | Neprilysin level 126–450 pg/mL (n = 15) | Neprilysin level > 450 pg/mL (n = 15) | Overall p.value | Highest-level vs. lower groups p.value | |
|---|---|---|---|---|---|---|
Age, years | 58.5 ± 12.8 | 59.8 ± 11.7 | 54.8 ± 9.8 | 60.5 ± 16.8 | 0.37 | 0.58 |
Gender, male | 56 (82.4%) | 31 (81.6%) | 13 (86.7%) | 12 (80.0%) | 0.88 | 1 |
Hypertension | 25 (36.8%) | 11 (28.9%) | 6 (40.0%) | 8 (53.3%) | 0.25 | 0.23 |
Diabetes mellitus | 13 (19.1%) | 7 (18.4%) | 3 (20.0%) | 3 (20.0%) | 0.99 | 1 |
Hypercholesterolemia | 33 (48.5%) | 19 (50.0%) | 6 (40.0%) | 8 (53.3%) | 0.74 | 0.90 |
Current smoking | 43 (63.2%) | 26 (86.4%) | 8 (53.3%) | 9 (60.0%) | 0.57 | 1 |
Body Mass Index, kg/m2 | 26.1 [24.0, 29.4] | 26.0 [23.6, 29.3] | 28.5 [26.3, 29.3] | 25.8 [23.4, 30.0] | 0.45 | 0.75 |
Heart rate, bpm | 77 ± 17 | 75 ± 15 | 80 ± 19 | 78 ± 20 | 0.62 | 0.77 |
Systolic BP, mmHg | 142 ± 25 | 145 ± 28 | 134 ± 22 | 145 ± 22 | 0.39 | 0.65 |
Diastolic BP, mmHg | 85 ± 19 | 87 ± 16 | 78 ± 21 | 86 ± 22 | 0.26 | 0.83 |
Anterior STEMI | 27 (39.7%) | 15 (39.5%) | 6 (40.0%) | 6 (40.0%) | 1 | 1 |
Symptoms to balloon, hours | 4.7 [3.1, 8.7] | 4.5 [3.2, 6.0] | 3.7 [2.7, 8.6] | 6.8 [3.9, 10.8] | 0.36 | 0.18 |
Thrombolysis | 2 (2.9%) | 1 (2.6%) | 0 | 1 (6.7%) | 0.69 | 0.40 |
GFR, mL/min/1.73m2 | 93 ± 17 | 91 ± 16 | 96 ± 19 | 93 ± 16 | 0.65 | 0.88 |