| |
Overall (n = 68)
|
Neprilysin level ≤ 125 pg/mL (n = 38)
|
Neprilysin level 126–450 pg/mL (n = 15)
|
Neprilysin level > 450 pg/mL (n = 15)
|
Overall p.value
|
Highest-level vs. lower groups p.value
|
|---|
|
Age, years
|
58.5 ± 12.8
|
59.8 ± 11.7
|
54.8 ± 9.8
|
60.5 ± 16.8
|
0.37
|
0.58
|
|
Gender, male
|
56 (82.4%)
|
31 (81.6%)
|
13 (86.7%)
|
12 (80.0%)
|
0.88
|
1
|
|
Hypertension
|
25 (36.8%)
|
11 (28.9%)
|
6 (40.0%)
|
8 (53.3%)
|
0.25
|
0.23
|
|
Diabetes mellitus
|
13 (19.1%)
|
7 (18.4%)
|
3 (20.0%)
|
3 (20.0%)
|
0.99
|
1
|
|
Hypercholesterolemia
|
33 (48.5%)
|
19 (50.0%)
|
6 (40.0%)
|
8 (53.3%)
|
0.74
|
0.90
|
|
Current smoking
|
43 (63.2%)
|
26 (86.4%)
|
8 (53.3%)
|
9 (60.0%)
|
0.57
|
1
|
|
Body Mass Index, kg/m2
|
26.1 [24.0, 29.4]
|
26.0 [23.6, 29.3]
|
28.5 [26.3, 29.3]
|
25.8 [23.4, 30.0]
|
0.45
|
0.75
|
|
Heart rate, bpm
|
77 ± 17
|
75 ± 15
|
80 ± 19
|
78 ± 20
|
0.62
|
0.77
|
|
Systolic BP, mmHg
|
142 ± 25
|
145 ± 28
|
134 ± 22
|
145 ± 22
|
0.39
|
0.65
|
|
Diastolic BP, mmHg
|
85 ± 19
|
87 ± 16
|
78 ± 21
|
86 ± 22
|
0.26
|
0.83
|
|
Anterior STEMI
|
27 (39.7%)
|
15 (39.5%)
|
6 (40.0%)
|
6 (40.0%)
|
1
|
1
|
|
Symptoms to balloon, hours
|
4.7 [3.1, 8.7]
|
4.5 [3.2, 6.0]
|
3.7 [2.7, 8.6]
|
6.8 [3.9, 10.8]
|
0.36
|
0.18
|
|
Thrombolysis
|
2 (2.9%)
|
1 (2.6%)
|
0
|
1 (6.7%)
|
0.69
|
0.40
|
|
GFR, mL/min/1.73m2
|
93 ± 17
|
91 ± 16
|
96 ± 19
|
93 ± 16
|
0.65
|
0.88
|
- BP blood pressure, GFR glomerular filtration rate, STEMI ST-elevation myocardial infarction
