Significant association between rs28362491 polymorphism in NF-κB1 gene and coronary artery disease: a meta-analysis

Table 3 Association between rs28362491 polymorphism and coronary artery disease

Genetic model	No. of cohorts	Association			Effect model	Heterogeneity
Genetic model	No. of cohorts	OR	95%CI	P-value	Effect model	I² (%)	P-value
Overall
D vs. I	17	1.16	1.11–1.21	<0.01	F	21	0.20
DD vs. II	17	1.37	1.25–1.49	<0.01	F	32	0.10
DI vs. II	17	1.11	1.05–1.18	<0.01	F	0	0.95
DD + DI vs. II	17	1.17	1.11–1.24	<0.01	F	0	0.84
DD vs. DI + II	17	1.29	1.15–1.43	<0.01	R	38	0.06
Asian
D vs. I	13	1.21	1.15–1.27	<0.01	F	0	0.52
DD vs. II	13	1.50	1.35–1.67	<0.01	F	0	0.58
DI vs. II	13	1.11	1.03–1.20	<0.01	F	0	0.90
DD + DI vs. II	13	1.20	1.12–1.28	<0.01	F	0	0.79
DD vs. DI + II	13	1.43	1.30–1.57	<0.01	F	0	0.67
Caucasian
D vs. I	4	1.07	0.99–1.15	0.08	F	0	0.58
DD vs. II	4	1.11	0.95–1.29	0.20	F	0	0.44
DI vs. II	4	1.12	1.00–1.25	0.05	F	0	0.67
DD + DI vs. II	4	1.12	1.00–1.24	0.04	F	0	0.72
DD vs. DI + II	4	1.04	0.90–1.20	0.59	F	15	0.31
Female
D vs. I	8	1.14	1.06–1.24	<0.01	F	14	0.32
DD vs. II	8	1.37	1.16–1.61	<0.01	F	41	0.11
DI vs. II	8	1.06	0.94–1.19	0.36	F	0	0.82
DD + DI vs. II	8	1.13	1.01–1.26	0.04	F	0	0.83
DD vs. DI + II	8	1.37	1.08–1.73	<0.01	R	53	0.04
Male
D vs. I	9	1.16	1.05–1.27	<0.01	R	55	0.02
DD vs. II	9	1.30	1.07–1.60	0.01	R	59	0.01
DI vs. II	9	1.18	1.04–1.34	<0.01	R	43	0.08
DD + DI vs. II	9	1.21	1.07–1.37	<0.01	R	46	0.06
DD vs. DI + II	9	1.19	0.99–1.42	0.06	R	57	0.02

OR Odds ratio, CI Confidence interval, F Fixed-effects model, R Random-effects model

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