Variables | Total N = 15,867 | Underweight BMI < 18.5 (n = 830) | Normal 18.5 ≤ BMI < 23 (n = 4965) | Overweight 23 ≤ BMI < 25 (n = 3716) | Obese, class I 25 ≤ BMI < 30 (n = 5263) | Obese, class II BMI ≥ 30 (n = 1093) | p value |
---|---|---|---|---|---|---|---|
Age | 68.09 ± 11.93 | 72.42 ± 12.69 | 69.46 ± 12.01 | 68.11 ± 11.65 | 66.62 ± 11.57 | 65.64 ± 11.90 | < 0.001 |
Male | 8860 (55.8) | 352 (42.4) | 2610 (52.6) | 2158 (58.1) | 3189 (60.6) | 551 (50.4) | < 0.001 |
Current smoker | 3421 (21.6) | 147 (17.7) | 990 (19.9) | 764 (20.6) | 1291 (24.5) | 229 (21.0) | < 0.001 |
Current drinking | 1808 (11.4) | 60 (7.2) | 476 (9.6) | 412 (11.1) | 722 (13.7) | 138 (12.6) | < 0.001 |
Comorbidities | |||||||
Hypertension | 8504 (53.6) | 296 (35.7) | 2306 (46.4) | 1954 (52.6) | 3205 (60.9) | 743 (68.0) | < 0.001 |
Diabetes mellitus | 2712 (17.1) | 68 (8.2) | 641 (12.9) | 666 (17.9) | 1064 (20.2) | 273 (25.0) | < 0.001 |
CAD | 3667 (23.1) | 180 (21.7) | 1073 (21.6) | 909 (24.5) | 1236 (23.5) | 269 (24.6) | 0.012 |
CHF | 2194 (13.8) | 171 (20.6) | 747 (15.0) | 500 (13.5) | 642 (12.2) | 134 (12.3) | < 0.001 |
Stroke | 2024 (12.8) | 113 (13.6) | 628 (12.6) | 489 (13.2) | 658 (12.5) | 136 (12.4) | 0.820 |
Renal failure | 396 (2.4) | 39 (4.7) | 129 (2.6) | 81 (2.2) | 130 (2.5) | 17 (1.6) | < 0.001 |
Underwent dialysis | 22 (5.5) | 2 (5.1) | 10 (7.8) | 3 (3.7) | 6 (4.6) | 1 (5.9) | 0.002 |
Renal transplant | 7 (1.8) | 0 (0) | 3 (2.3) | 0 (0) | 4 (3.1) | 0 (0) | 0.001 |
Rheumatic heart disease | 887 (5.6) | 105 (12.7) | 386 (7.8) | 198 (5.3) | 169 (3.2) | 29 (2.7) | < 0.001 |
COPD | 613 (3.9) | 57 (6.9) | 202 (4.1) | 132 (3.6) | 179 (3.4) | 43 (3.9) | < 0.001 |
Cancer | 260 (1.6) | 27 (3.3) | 105 (2.1) | 61 (1.6) | 55 (1.0) | 12 (1.1) | < 0.001 |
First diagnosis of AF | 1609 (10.1) | 84 (10.1) | 482 (9.7) | 403 (10.8) | 545 (10.4) | 95 (8.7) | < 0.001 |
Non-valvular AF | 13,792 (86.9) | 610 (73.5) | 4106 (82.7) | 3265 (87.9) | 4796 (91.1) | 1015 (92.9) | < 0.001 |
On admission value | |||||||
HR at rest (bmp/min) | 88.64 ± 27.68 | 93.45 ± 29.77 | 88.57 ± 27.90 | 88.05 ± 27.92 | 87.87 ± 26.85 | 91.03 ± 27.35 | < 0.001 |
SBP (mmHg) | 130.57 ± 20.45 | 123.69 ± 21.04 | 128.50 ± 20.57 | 130.50 ± 20.47 | 132.64 ± 19.85 | 135.45 ± 19.81 | < 0.001 |
DBP (mmHg) | 78.82 ± 13.33 | 74.11 ± 13.52 | 77.10 ± 13.12 | 78.69 ± 13.15 | 80.46 ± 13.21 | 82.74 ± 13.20 | < 0.001 |
QTc (ms) | 419.22 ± 64.13 | 416.15 ± 60.39 | 418.82 ± 65.16 | 417.48 ± 61.78 | 419.31 ± 62.92 | 428.15 ± 59.31 | 0.003 |
LVEDd (ms) | 49.99 ± 8.18 | 48.26 ± 9.41 | 49.75 ± 8.71 | 49.82 ± 8.02 | 50.36 ± 7.74 | 51.00 ± 7.18 | < 0.001 |
LAAP (mm) | 42.73 ± 9.11 | 43.42 ± 11.75 | 42.39 ± 9.46 | 42.11 ± 9.21 | 43.02 ± 8.33 | 44.28 ± 8.46 | < 0.001 |
LVEF | < 0.001 | ||||||
< 40% | 1151 (7.3) | 77 (9.3) | 421 (8.5) | 241 (6.5) | 338 (6.4) | 74 (6.8) | – |
40–49% | 1463 (9.2) | 95 (11.4) | 468 (9.4) | 354 (9.5) | 450 (8.6) | 96 (8.8) | – |
≥ 50% | 13,253 (83.5) | 658 (79.3) | 4076 (82.1) | 3121 (84.0) | 4475 (85.0) | 923 (84.4) | – |
CHADS2score | 0.001 | ||||||
0–1 | 9541 (60.1) | 489 (58.9) | 3058 (61.6) | 2265 (61.0) | 3126 (59.4) | 603 (55.2) | – |
2 | 3519 (22.2) | 196 (23.6) | 1088 (21.9) | 773 (20.8) | 1179 (22.4) | 283 (25.9) | – |
3–6 | 2782 (17.5) | 141 (17.0) | 809 (16.3) | 670 (18.0) | 955 (18.1) | 207 (18.9) | – |
CHA2DS2-VAS score | < 0.001 | ||||||
0–1 | 4646 (29.3) | 184 (22.2) | 1396 (28.1) | 1101 (29.6) | 1674 (31.8) | 291 (26.6) | – |
2–4 | 9082 (57.2) | 519 (62.5) | 2937 (59.2) | 2107 (56.7) | 2881 (54.7) | 638 (58.4) | – |
5–9 | 2114 (13.3) | 123 (14.8) | 622 (12.5) | 500 (13.5) | 705 (13.4) | 164 (15.0) | – |
Medication history | |||||||
Beta-blocker | 4485 (28.3) | 190 (22.9) | 1289 (26.0) | 1002 (27.0) | 1633 (31.0) | 371 (33.9) | < 0.001 |
CCB | 2361 (14.9) | 76 (9.2) | 601 (12.1) | 500 (13.5) | 982 (18.7) | 202 (18.5) | < 0.001 |
Antiarrhythmic agents | 1404 (8.8) | 35 (4.2) | 378 (7.6) | 329 (8.9) | 540 (10.3) | 122 (11.2) | < 0.001 |
Antiplatelet agents | 1137 (7.2) | 48 (5.8) | 351 (7.1) | 286 (7.7) | 359 (6.8) | 93 (8.5) | 0.094 |
Warfarin | 2097 (13.2) | 118 (14.2) | 653 (13.2) | 509 (13.7) | 668 (12.7) | 149 (13.6) | 0.127 |
Aspirin | 3302 (20.8) | 114 (13.7) | 952 (19.2) | 786 (21.2) | 1185 (22.5) | 265 (24.2) | < 0.001 |