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Table 1 Summary results of BMI associated independent instrumental SNPs

From: Higher BMI is linked to an increased risk of heart attacks in European adults: a Mendelian randomisation study

SNP

Chr

Position

EA

OA

EAF

Beta

SE

P

Gene

rs1343424

1

49,376,820

C

T

0.251

0.02

0.004

8.56E-09

AGBL4

rs2422134

1

72,514,701

C

G

0.508

−0.022

0.003

2.49E-13

NEGR1

rs6690871

1

74,977,277

G

A

0.407

0.022

0.003

1.28E-12

LRRC53

rs505066

1

96,882,671

A

C

0.285

0.025

0.004

2.35E-09

(UBE2WP1)

rs7550711

1

110,082,886

T

C

0.026

0.066

0.009

9.51E-14

GPR61

rs4478775

1

177,770,097

A

G

0.223

0.025

0.004

1.98E-11

SEC16B

rs2820292

1

201,784,287

A

C

0.432

−0.02

0.003

1.58E-10

NAV1

rs13411762

2

554,109

C

T

0.928

0.033

0.006

5.93E-09

(TMEM18)

rs13391869

2

606,213

G

A

0.848

−0.022

0.004

1.65E-08

(TMEM18)

rs10495749

2

24,730,847

A

G

0.231

−0.021

0.004

3.21E-09

NCOA1

rs11126666

2

26,928,811

G

A

0.745

−0.021

0.003

5.71E-10

KCNK3

rs13011109

2

58,857,419

G

C

0.612

0.018

0.003

6.84E-09

FANCL

rs6545714

2

59,307,725

G

A

0.399

0.018

0.003

3.19E-09

(FANCL)

rs2890652

2

142,959,931

T

C

0.839

−0.028

0.005

2.24E-08

(LRP1B)

rs1528435

2

181,550,962

T

C

0.62

0.018

0.003

4.68E-09

(UBE2E3)

rs7599312

2

213,413,231

G

A

0.732

0.022

0.003

4.88E-11

(ERBB4)

rs10510554

3

25,099,776

T

C

0.431

−0.018

0.003

1.78E-09

RARB

rs1916801

3

61,187,046

A

T

0.595

0.019

0.003

8.13E-10

FHIT

rs3849570

3

81,792,112

A

C

0.348

0.019

0.003

1.61E-08

GBE1

rs10511073

3

85,653,460

G

A

0.646

−0.021

0.003

1.46E-10

CADM2

rs16851483

3

141,275,436

G

T

0.934

−0.048

0.008

1.77E-10

RASA2

rs4494964

3

185,776,491

T

C

0.142

−0.04

0.005

1.39E-15

ETV5

rs13144044

4

45,082,236

C

G

0.534

−0.025

0.004

1.02E-11

(GNPDA2)

rs17001654

4

77,129,568

C

G

0.852

−0.031

0.005

3.88E-09

SCARB2

rs13107325

4

103,188,709

C

T

0.925

−0.048

0.007

1.15E-12

SLC39A8

rs11727676

4

145,659,064

C

T

0.096

−0.036

0.006

1.11E-08

HHIP

rs6871667

5

74,604,742

A

G

0.401

−0.017

0.003

1.44E-08

(HMGCR)

rs280275

6

50,668,612

A

G

0.952

−0.039

0.007

4.46E-09

(TFAP2D)

rs4141973

6

50,946,521

T

C

0.134

0.028

0.005

5.51E-09

(FTH1P5)

rs9400239

6

108,977,663

C

T

0.706

0.019

0.003

6.10E-09

FOXO3

rs13191362

6

163,033,350

A

G

0.875

0.028

0.005

3.94E-09

PARK2

rs1167827

7

75,163,169

A

G

0.435

−0.02

0.003

4.64E-10

HIP1

rs2245368

7

76,608,143

T

C

0.833

−0.032

0.006

1.34E-08

DTX2P1

rs2922763

8

76,573,711

G

T

0.274

−0.024

0.004

2.73E-10

(HNF4G)

rs2033732

8

85,079,709

C

T

0.744

0.019

0.004

2.06E-08

(RALYL)

rs4740619

9

15,634,326

T

C

0.551

0.018

0.003

3.87E-09

CCDC171

rs1412234

9

28,410,683

C

T

0.33

0.024

0.004

4.97E-09

LINGO2

rs6477694

9

111,932,342

C

T

0.354

0.017

0.003

9.95E-09

(FRRS1L)

rs1928295

9

120,378,483

C

T

0.43

−0.019

0.003

6.62E-10

(TLR4)

rs10733682

9

129,460,914

A

G

0.473

0.017

0.003

9.95E-09

LMX1B

rs7899106

10

87,410,904

A

G

0.95

−0.04

0.007

1.32E-08

GRID1

rs17094222

10

102,395,440

C

T

0.213

0.025

0.004

2.83E-11

(PAX2)

rs17747324

10

114,752,503

C

T

0.227

−0.023

0.004

1.16E-09

TCF7L2

rs1374262

11

8,458,749

G

A

0.532

0.017

0.003

1.44E-08

STK33

rs4514364

11

27,456,059

C

T

0.316

0.02

0.003

1.72E-09

LGR4

rs2176598

11

43,864,278

T

C

0.246

0.02

0.004

1.90E-08

HSD17B12

rs2856650

11

47,365,199

G

A

0.703

−0.02

0.003

9.87E-10

MYBPC3

rs12286929

11

115,022,404

G

A

0.527

0.022

0.003

1.28E-12

(CADM1)

rs2720296

12

50,169,070

G

A

0.613

−0.02

0.003

9.87E-10

(LSM6P2)

rs11057405

12

122,781,897

A

G

0.106

−0.031

0.006

1.19E-08

CLIP1

rs7988412

13

28,000,282

C

T

0.815

−0.026

0.005

1.10E-08

GTF3A

rs2797084

13

54,071,824

T

C

0.86

− 0.032

0.006

6.12E-09

(OLFM4)

rs10132280

14

25,928,179

A

C

0.3

−0.023

0.003

6.68E-12

(STXBP6)

rs2370982

14

79,890,677

T

C

0.216

0.025

0.005

2.43E-08

NRXN3

rs3736485

15

51,748,610

A

G

0.461

0.018

0.003

6.84E-09

DMXL2

rs12905371

15

67,845,930

C

T

0.736

0.021

0.004

4.46E-09

MAP 2 K5

rs12448257

16

3,599,655

G

A

0.784

−0.024

0.004

8.42E-10

NLRC3

rs2531995

16

4,013,467

C

T

0.379

−0.024

0.004

8.46E-10

ADCY9

rs2354584

16

19,778,575

A

G

0.87

0.035

0.006

1.10E-09

IQCK

rs2650492

16

28,333,411

A

G

0.298

0.021

0.004

1.67E-09

SBK1

rs2303222

16

31,085,470

C

T

0.378

−0.018

0.003

1.78E-09

ZNF668

rs1477199

16

53,712,135

A

G

0.864

−0.024

0.004

1.90E-08

RPGRIP1L

rs7205986

16

53,755,146

G

A

0.511

0.025

0.003

3.68E-16

FTO

rs3026101

17

5,280,440

C

T

0.301

0.018

0.003

1.23E-08

NUP88

rs12949279

17

78,558,411

C

T

0.439

−0.018

0.003

8.25E-09

RPTOR

rs891389

18

21,087,531

C

T

0.655

−0.021

0.004

2.20E-08

RMC1

rs7243357

18

56,883,319

G

T

0.176

−0.022

0.004

2.90E-08

(GRP)

rs4940929

18

57,803,890

G

C

0.583

0.027

0.004

3.43E-11

(MC4R)

rs9944545

18

57,958,244

T

C

0.297

0.034

0.003

5.66E-24

(MC4R)

rs17724992

19

18,454,825

A

G

0.733

0.019

0.004

1.49E-08

PGPEP1

rs29944

19

34,306,898

A

G

0.327

−0.018

0.003

2.07E-08

(KCTD15)

rs2075650

19

45,395,619

A

G

0.854

0.026

0.005

4.92E-09

TOMM40

rs9304665

19

47,602,577

A

T

0.765

0.025

0.004

7.61E-09

ZC3H4

  1. Table 1 lists summary results of the 73 independent SNPs used as instruments in our MR analysis. These SNPs were associated with BMI (P < 5 × 10−8) in the European adults in the GIANT study. One SNP rs2075650 appeared to be an outlier. We re-did MR analysis without this SNP. SNP: single nucleotide polymorphism, Chr: chromosome, Position: location of the SNP in the chromosome according to Build 37, EA: effect allele, OA: the other allele, EAF: effect allele frequency. Beta, SE and P are estimated SNP effect, standard error and p-value from the GIANT GWAS study. Gene: genes of the SNPs located in or close to. For intergenic SNPs, their nearest genes are provided in brackets
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BMC Cardiovascular Disorders

ISSN: 1471-2261

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