Fig. 4

Rno-miR-30c-5p promoted the apoptosis, and activated NF-κB pathway in IR myocardial cells by targeting SIRT1. b The expression of SIRT1 was detected by Western blot (N = 3 each group). b The expression of p-IκBα, IκBα, p-NF-κB p65 and NF-κB p65 was detected by Western blot (N = 3 each group). c The apoptotic index (%) was measured by flow cytometry (N = 3 each group). d The expression of Bax, Bcl-2 and caspase-3 was detected by Western blot (N = 3 each group). Data were presented as mean ± SD (three independent repetitions for each sample). ^*P < 0.05, vs. Control and si-NC group (a); ^*P < 0.05, vs. si-NC + inhibitor NC group, ^#P < 0.05, vs. siRNA2 + inhibitor NC group (b-d)