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Table 3 Main results of pooled ORs in meta-analysis of MMP9 gene polymorphisms and CAD risk

From: The association between Matrix Metallo-proteinases-9 (MMP-9) gene family polymorphisms and risk of Coronary Artery Disease (CAD): a systematic review and meta-analysis

Subgroup

 

Sample size

Test of association

Test of heterogeneity

Test of publication bias (Begg’s test)

Test of publication bias (Egger’s test)

 

Genetic model

Case/Control

OR

95% CI (p-value)

I2 (%)

P

Z

P

T

P

MMP-9 (C1562T)

Overall

Dominant model

11,792 / 8280

1.41

1.23–161 (≤0.001)

68.8

≤0.001

1.48

0.13

1.62

0.11

Recessive model

11,792 / 8280

1.59

1.29–1.96 (≤0.001)

18.3

0.19

1.34

0.17

1.49

0.14

Allelic model

11,792 / 8280

1.38

1.23–1.55(≤0.001)

68.7

≤0.001

1.39

0.16

1.54

0.13

TT vs. CC

11,792 / 8280

1.70

1.35–2.13 (≤0.001)

34

0.42

1.56

0.11

2.05

0.04

CT vs. CC

11,792 / 8280

1.35

1.18–1.54 (≤0.001)

65.4

≤0.001

1.48

0.13

1.62

0.11

Subgroup

Asian

Dominant model

7483 / 5152

1.47

1.25–1.74 (≤0.001)

64.5

≤0.001

−0.72

0.47

−0.14

0.88

Recessive model

7483 / 5152

2.06

1.57–2.71 (≤0.001)

0

0.45

1.94

0.05

1.39

0.18

Allelic model

7483 / 5152

1.45

1.26–1.67 (≤0.001)

64.3

≤0.001

0.99

0.32

1.64

0.15

TT vs. CC

7483 / 5152

2.42

1.77–3.32 (≤0.001)

0

0.45

0

1

−0.18

0.86

CT vs. CC

7483 / 5152

1.39

1.19–1.64(≤0.001)

60.8

≤0.001

−0.25

0.80

0.15

0.88

European

Dominant model

3230 / 2331

1.26

0.97–1.66 (0.08)

76.3

≤0.001

0.78

0.45

0.84

0.43

Recessive model

3230 / 2331

1.05

0.75–1.47 (0.77)

0

0.59

1.04

0.29

0.62

0.55

Allelic model

3230 / 2331

1.22

0.97–1.53(0.08)

75.5

≤0.001

−1.73

0.08

−0.69

0.51

TT vs. CC

3230 / 2331

1.10

0.78–1.54 (0.59)

32.1

0.15

−0.21

0.83

0.2

0.82

CT vs. CC

3230 / 2331

1.25

0.96–1.64 (0.09)

74.1

≤0.001

−0.25

0.80

−0.68

0.52

ACS

Dominant model

5862 / 4018

1.66

1.32–2.10 (≤0.001)

76.1

≤0.001

−0.25

0.80

0.89

0.39

Recessive model

5862 / 4018

1.32

0.93–1.86 (0.12)

2.8

0.416

−0.25

0.80

−0.63

0.54

Allelic model

5862 / 4018

1.57

1.29–1.92 (≤0.001)

74.5

≤0.001

−0.35

0.72

−0.75

0.46

TT vs. CC

5862 / 4018

1.40

0.99–1.98 (0.06)

35.1

0.11

0.05

0.96

−0.57

0.57

CT vs. CC

5862 / 4018

1.62

1.28–2.04 (≤0.001)

75

≤0.001

−0.45

0.65

−0.99

0.34

Stable

Dominant model

5930 / 4262

1.26

1.07–1.48 (≤0.001)

60.9

≤0.001

0.38

0.70

0.24

0.81

Recessive model

5930 / 4262

1.77

1.37–2.30 (≤0.001)

23.6

0.18

−0.12

0.90

−0.42

0.68

Allelic model

5930 / 4262

1.26

1.09–1.46 (≤0.001)

63.9

≤0.001

0.12

0.90

−0.49

0.63

TT vs. CC

5930 / 4262

1.95

1.45–2.64 (≤0.001)

31.9

0.10

1.57

0.11

14.14

0.04

CT vs. CC

5930 / 4262

1.20

1.03–1.39 (0.01)

52.2

≤0.001

0.52

0.60

0.38

0.76

MMP-9 (R279Q)

Overall

Dominant model

5525 / 2497

0.92

0.83–1.02 (0.12)

38.7

0.13

0.05

0.96

−0.23

0.83

Recessive model

5525 / 2497

0.88

0.76–1.02 (0.08)

0

0.48

−0.18

0.85

−0.21

0. 83

Allelic model

5525 / 2497

0.93

0.86–1(0.05)

38.1

0.13

0.05

0.96

−0.06

0.95

GG vs. AA

5525 / 2497

0.86

0.73–1.01(0.07)

17.9

0.29

0.45

0.65

0.33

0.74

AG vs. AA

5525 / 2497

0.94

0.85–1.05 (0.26)

29.7

0.20

0.19

0.85

−0.19

0.85

Subgroup

Asian

Dominant model

4162/ 1923

0.93

0.83–1.04 (0.19)

45.4

0.13

−0.98

0.32

−1.70

0.18

Recessive model

4162/ 1923

0.86

0.72–1.01 (0.06)

36

0.19

0.56

0.57

0.37

0.73

Allelic model

4162/ 1923

0.92

0.85–1 (0.06)

59.6

0.06

0.09

0.92

−0.03

0.97

GG vs. AA

4162/ 1923

0.85

0.71–1.02 (0.08)

53.7

0.09

1.16

0.24

0.92

0.38

AG vs. AA

4162/ 1923

0.95

0.84–1.07 (0.41)

15.3

0.31

1.34

0.18

1.58

0.15

European

Dominant model

1363 / 574

0.91

0.74–1.13 (0.38)

53.2

0.11

0.27

0.78

0.46

0.65

Recessive model

1363 / 574

0.96

0.70–1.32 (0.80)

0

0.84

0.55

0.58

0.74

0.47

Allelic model

1363 / 574

0.94

0.81–1.10 (0.45)

10.1

0.32

0.27

0.78

0.10

0.92

GG vs. AA

1363 / 574

0.90

0.64–1.26 (0.53)

0

0.68

0

1

0.38

0.71

AG vs. AA

1363 / 574

0.91

0.73–1.14 (0.39)

58.9

0.08

0.52

0.60

−0.47

0.72

MMP-9 (P574R)

Overall

Dominant model

1272 / 785

1.05

0.72–1.53 (0.81)

0.69

0.07

*

*

*

*

Recessive model

1272 / 785

1.01

0.69–1.49 (0.95)

0

0.47

*

*

*

*

Allelic model

1272 / 785

0.93

0.79–1.10 (0.41)

0

0.41

*

*

*

*

RR vs. PP

1272 / 785

0.97

0.55–1.44 (0.87)

0

0.38

*

*

*

*

PR vs. PP

1272 / 785

1.03

0.72–1.48 (0.87)

63.7

0.09

*

*

*

*

MMP-9 (R668Q)

Overall

Dominant model

1272 / 785

1.19

0.66–2.13 (0.56)

88.3

≤0.001

*

*

*

*

Recessive model

1272 / 785

1.12

0.68–1.84 (0.64)

21.2

0.26

*

*

*

*

Allelic model

1272 / 785

1.11

0.73–1.69 (0.62)

85.1

0.01

*

*

*

*

QQ vs. RR

1272 / 785

1.26

0.55–2.89 (0.58)

63.1

0.01

*

*

*

*

RQ vs. RR

1272 / 785

1.18

0.68–2.06 (0.43)

86.4

≤0.001

*

*

*

*

  1. *Begg’s and Egger’s test were not calculable
  2. ACS acute coronary syndrome, OR odds ratio, CI confidence interval, MMP matrix metalloproteinase