Subgroup |  | Sample size | Test of association | Test of heterogeneity | Test of publication bias (Begg’s test) | Test of publication bias (Egger’s test) | ||||
---|---|---|---|---|---|---|---|---|---|---|
 | Genetic model | Case/Control | OR | 95% CI (p-value) | I2 (%) | P | Z | P | T | P |
MMP-9 (C1562T) | ||||||||||
Overall | Dominant model | 11,792 / 8280 | 1.41 | 1.23–161 (≤0.001) | 68.8 | ≤0.001 | 1.48 | 0.13 | 1.62 | 0.11 |
Recessive model | 11,792 / 8280 | 1.59 | 1.29–1.96 (≤0.001) | 18.3 | 0.19 | 1.34 | 0.17 | 1.49 | 0.14 | |
Allelic model | 11,792 / 8280 | 1.38 | 1.23–1.55(≤0.001) | 68.7 | ≤0.001 | 1.39 | 0.16 | 1.54 | 0.13 | |
TT vs. CC | 11,792 / 8280 | 1.70 | 1.35–2.13 (≤0.001) | 34 | 0.42 | 1.56 | 0.11 | 2.05 | 0.04 | |
CT vs. CC | 11,792 / 8280 | 1.35 | 1.18–1.54 (≤0.001) | 65.4 | ≤0.001 | 1.48 | 0.13 | 1.62 | 0.11 | |
Subgroup | ||||||||||
Asian | Dominant model | 7483 / 5152 | 1.47 | 1.25–1.74 (≤0.001) | 64.5 | ≤0.001 | −0.72 | 0.47 | −0.14 | 0.88 |
Recessive model | 7483 / 5152 | 2.06 | 1.57–2.71 (≤0.001) | 0 | 0.45 | 1.94 | 0.05 | 1.39 | 0.18 | |
Allelic model | 7483 / 5152 | 1.45 | 1.26–1.67 (≤0.001) | 64.3 | ≤0.001 | 0.99 | 0.32 | 1.64 | 0.15 | |
TT vs. CC | 7483 / 5152 | 2.42 | 1.77–3.32 (≤0.001) | 0 | 0.45 | 0 | 1 | −0.18 | 0.86 | |
CT vs. CC | 7483 / 5152 | 1.39 | 1.19–1.64(≤0.001) | 60.8 | ≤0.001 | −0.25 | 0.80 | 0.15 | 0.88 | |
European | Dominant model | 3230 / 2331 | 1.26 | 0.97–1.66 (0.08) | 76.3 | ≤0.001 | 0.78 | 0.45 | 0.84 | 0.43 |
Recessive model | 3230 / 2331 | 1.05 | 0.75–1.47 (0.77) | 0 | 0.59 | 1.04 | 0.29 | 0.62 | 0.55 | |
Allelic model | 3230 / 2331 | 1.22 | 0.97–1.53(0.08) | 75.5 | ≤0.001 | −1.73 | 0.08 | −0.69 | 0.51 | |
TT vs. CC | 3230 / 2331 | 1.10 | 0.78–1.54 (0.59) | 32.1 | 0.15 | −0.21 | 0.83 | 0.2 | 0.82 | |
CT vs. CC | 3230 / 2331 | 1.25 | 0.96–1.64 (0.09) | 74.1 | ≤0.001 | −0.25 | 0.80 | −0.68 | 0.52 | |
ACS | Dominant model | 5862 / 4018 | 1.66 | 1.32–2.10 (≤0.001) | 76.1 | ≤0.001 | −0.25 | 0.80 | 0.89 | 0.39 |
Recessive model | 5862 / 4018 | 1.32 | 0.93–1.86 (0.12) | 2.8 | 0.416 | −0.25 | 0.80 | −0.63 | 0.54 | |
Allelic model | 5862 / 4018 | 1.57 | 1.29–1.92 (≤0.001) | 74.5 | ≤0.001 | −0.35 | 0.72 | −0.75 | 0.46 | |
TT vs. CC | 5862 / 4018 | 1.40 | 0.99–1.98 (0.06) | 35.1 | 0.11 | 0.05 | 0.96 | −0.57 | 0.57 | |
CT vs. CC | 5862 / 4018 | 1.62 | 1.28–2.04 (≤0.001) | 75 | ≤0.001 | −0.45 | 0.65 | −0.99 | 0.34 | |
Stable | Dominant model | 5930 / 4262 | 1.26 | 1.07–1.48 (≤0.001) | 60.9 | ≤0.001 | 0.38 | 0.70 | 0.24 | 0.81 |
Recessive model | 5930 / 4262 | 1.77 | 1.37–2.30 (≤0.001) | 23.6 | 0.18 | −0.12 | 0.90 | −0.42 | 0.68 | |
Allelic model | 5930 / 4262 | 1.26 | 1.09–1.46 (≤0.001) | 63.9 | ≤0.001 | 0.12 | 0.90 | −0.49 | 0.63 | |
TT vs. CC | 5930 / 4262 | 1.95 | 1.45–2.64 (≤0.001) | 31.9 | 0.10 | 1.57 | 0.11 | 14.14 | 0.04 | |
CT vs. CC | 5930 / 4262 | 1.20 | 1.03–1.39 (0.01) | 52.2 | ≤0.001 | 0.52 | 0.60 | 0.38 | 0.76 | |
MMP-9 (R279Q) | ||||||||||
Overall | Dominant model | 5525 / 2497 | 0.92 | 0.83–1.02 (0.12) | 38.7 | 0.13 | 0.05 | 0.96 | −0.23 | 0.83 |
Recessive model | 5525 / 2497 | 0.88 | 0.76–1.02 (0.08) | 0 | 0.48 | −0.18 | 0.85 | −0.21 | 0. 83 | |
Allelic model | 5525 / 2497 | 0.93 | 0.86–1(0.05) | 38.1 | 0.13 | 0.05 | 0.96 | −0.06 | 0.95 | |
GG vs. AA | 5525 / 2497 | 0.86 | 0.73–1.01(0.07) | 17.9 | 0.29 | 0.45 | 0.65 | 0.33 | 0.74 | |
AG vs. AA | 5525 / 2497 | 0.94 | 0.85–1.05 (0.26) | 29.7 | 0.20 | 0.19 | 0.85 | −0.19 | 0.85 | |
Subgroup | ||||||||||
Asian | Dominant model | 4162/ 1923 | 0.93 | 0.83–1.04 (0.19) | 45.4 | 0.13 | −0.98 | 0.32 | −1.70 | 0.18 |
Recessive model | 4162/ 1923 | 0.86 | 0.72–1.01 (0.06) | 36 | 0.19 | 0.56 | 0.57 | 0.37 | 0.73 | |
Allelic model | 4162/ 1923 | 0.92 | 0.85–1 (0.06) | 59.6 | 0.06 | 0.09 | 0.92 | −0.03 | 0.97 | |
GG vs. AA | 4162/ 1923 | 0.85 | 0.71–1.02 (0.08) | 53.7 | 0.09 | 1.16 | 0.24 | 0.92 | 0.38 | |
AG vs. AA | 4162/ 1923 | 0.95 | 0.84–1.07 (0.41) | 15.3 | 0.31 | 1.34 | 0.18 | 1.58 | 0.15 | |
European | Dominant model | 1363 / 574 | 0.91 | 0.74–1.13 (0.38) | 53.2 | 0.11 | 0.27 | 0.78 | 0.46 | 0.65 |
Recessive model | 1363 / 574 | 0.96 | 0.70–1.32 (0.80) | 0 | 0.84 | 0.55 | 0.58 | 0.74 | 0.47 | |
Allelic model | 1363 / 574 | 0.94 | 0.81–1.10 (0.45) | 10.1 | 0.32 | 0.27 | 0.78 | 0.10 | 0.92 | |
GG vs. AA | 1363 / 574 | 0.90 | 0.64–1.26 (0.53) | 0 | 0.68 | 0 | 1 | 0.38 | 0.71 | |
AG vs. AA | 1363 / 574 | 0.91 | 0.73–1.14 (0.39) | 58.9 | 0.08 | 0.52 | 0.60 | −0.47 | 0.72 | |
MMP-9 (P574R) | ||||||||||
Overall | Dominant model | 1272 / 785 | 1.05 | 0.72–1.53 (0.81) | 0.69 | 0.07 | * | * | * | * |
Recessive model | 1272 / 785 | 1.01 | 0.69–1.49 (0.95) | 0 | 0.47 | * | * | * | * | |
Allelic model | 1272 / 785 | 0.93 | 0.79–1.10 (0.41) | 0 | 0.41 | * | * | * | * | |
RR vs. PP | 1272 / 785 | 0.97 | 0.55–1.44 (0.87) | 0 | 0.38 | * | * | * | * | |
PR vs. PP | 1272 / 785 | 1.03 | 0.72–1.48 (0.87) | 63.7 | 0.09 | * | * | * | * | |
MMP-9 (R668Q) | ||||||||||
Overall | Dominant model | 1272 / 785 | 1.19 | 0.66–2.13 (0.56) | 88.3 | ≤0.001 | * | * | * | * |
Recessive model | 1272 / 785 | 1.12 | 0.68–1.84 (0.64) | 21.2 | 0.26 | * | * | * | * | |
Allelic model | 1272 / 785 | 1.11 | 0.73–1.69 (0.62) | 85.1 | 0.01 | * | * | * | * | |
QQ vs. RR | 1272 / 785 | 1.26 | 0.55–2.89 (0.58) | 63.1 | 0.01 | * | * | * | * | |
RQ vs. RR | 1272 / 785 | 1.18 | 0.68–2.06 (0.43) | 86.4 | ≤0.001 | * | * | * | * |