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Table 1 Baseline (demographic and clinical) characteristics of the total study population and of the two groups DOAC only and DOAC+ASA

From: Concomitant use of direct oral anticoagulants and aspirin versus direct oral anticoagulants alone in atrial fibrillation and flutter: a retrospective cohort

 

N

6004

DOAC Only

DOAC + Aspirin

p-value

DOAC Only

DOAC + Aspirin

p-value

3096

2908

3096

2908

Overall

By Treatment (unwtd)

By Treatment (wtd)

Age(mean, std dev)

 

70.5, 12.3

69.8, 12.5

71.3, 12.1

< 0.001

70.4, 12.1

70.3, 12.6

0.746

Median

 

71

71

72

 

71

71

 

IQ range

 

63–80

62–79

64–80

 

63–79

62–80

 

Female

2597

43%

42%

45%

0.047

43%

43%

0.759

Race

    

0.037

  

0.998

Black

390

6%

6%

7%

 

6%

7%

 

White

4797

80%

80%

80%

 

80%

80%

 

Other

411

7%

7%

6%

 

7%

7%

 

Unknown

406

7%

7%

6%

 

7%

7%

 

Tobacco

2716

45%

35%

56%

< 0.001

47%

48%

0.653

BMI(mean, std dev)

 

30.5, 7.3

30.4, 7.2

30.6, 7.5

0.304

30.7, 7.4

30.4, 7.3

0.135

Missing

 

13

9

4

    

Median

 

29.2

29.0

29.3

 

29.3

29.0

 

IQ range

 

25.7–34.1

25.6–33-9

25.7–34.3

 

25.8–34.1

25.5–33.9

 

CHADS VASc Score

(mean, std dev)

 

2.9, 1.8

2.5, 1.7

3.3, 1.8

< 0.001

2.9, 1.7

2.9, 1.8

0.763

Median

 

3

2

3

 

3

3

 

IQ range

 

2–4

1–4

2–4

 

2–4

2–4

 

HASBLED Score

(mean, std dev)

 

1.22, 0.84

0.67, 0.66

1.81, 0.57

 

NA

NA

 

CHF

828

14%

10%

17%

< 0.001

14%

14%

0.769

HTN

3758

63%

53%

73%

< 0.001

63%

64%

0.459

DM

1145

19%

14%

25%

< 0.001

19%

19%

0.734

Stroke

518

9%

7%

11%

< 0.001

9%

9%

0.923

Vascular Disease

1349

22%

16%

30%

< 0.001

22%

22%

0.794

Anemia

481

8%

6%

10%

< 0.001

8%

8%

0.877

CAD

804

13%

10%

17%

< 0.001

13%

13%

0.901

Cancer

925

15%

14%

17%

0.003

16%

16%

0.609

CKD

288

5%

4%

6%

< 0.001

5%

5%

0.968

COPD

528

9%

6%

11%

< 0.001

9%

9%

0.882

GI Bleed

176

3%

3%

3%

0.908

3%

3%

0.971

MI

347

6%

3%

9%

< 0.001

6%

6%

0.685

OSA

325

5%

5%

6%

0.045

5%

5%

0.905

PUD

167

3%

3%

3%

0.422

3%

3%

0.970

Index NSAID

683

11%

9%

13%

< 0.001

13%

13%

0.925

Index PPI

1733

29%

21%

37%

< 0.001

30%

31%

0.583

Index Statin

2769

46%

32%

61%

< 0.001

47%

48%

0.613

Index ACE

1489

25%

19%

31%

< 0.001

26%

26%

0.686

Index Beta B

1323

22%

15%

29%

< 0.001

23%

23%

0.951

  1. Abbreviations: unwtd unweighted, wtd weighted, BMI body mass index, CHF congestive heart failure. NA not applicable, HTN hypertension, DM diabetes mellitus, CAD coronary artery disease, CKD chronic kidney disease, COPD chronic obstructive pulmonary disease, GI gastrointestinal, MI myocardial infarction, OSA obstructive sleep apnea, PUD peptic ulcer disease, NSAID nonsteroidal anti-inflammatory drug, PPI proton pump inhibitors, ACEi angiotensin converting enzyme inhibitors, Beta B beta blockers