Association of methylenetetrahydrofolate reductase (MTHFR) variant C677T and risk of carotid atherosclerosis: a cross-sectional analysis of 730 Chinese Han adults in Chongqing

Table 5 Result of the risk factors of Carotid Atherosclerosis by Logistic regression analysis

	B-value	SE	Wald	P-value	OR	95%CI
Age	0.895	0.229	15.336	< 0.001^*	2.45	1.56 ~ 3.83
Gender	−0.507	0.238	4.532	0.033^*	0.60	0.38 ~ 0.96
Smoking	−0.070	0.202	0.120	0.729	0.93	0.63 ~ 1.38
Drinking	0.639	0.200	10.162	0.001^*	1.89	1.28 ~ 2.81
Dietary habit	−0.371	0.202	3.378	0.066	0.69	0.47 ~ 1.03
Sleep quality
poor			2.667	0.264
aduquate	0.389	0.259	2.248	0.134	1.48	0.89 ~ 2.45
good	0.455	0.301	2.283	0.131	1.58	0.87 ~ 2.85
BMI	−0.240	0.210	1.313	0.252	0.79	0.52 ~ 1.19
Hypertension	0.748	0.196	14.609	< 0.001^*	2.11	1.44 ~ 3.10
FBG
< 5.5 mmol/L			11.022	0.004^*
5.5–7 mmol/L	0.553	0.197	7.862	0.005^*	1.74	1.18 ~ 2.56
≧7 mmol/L	0.749	0.291	6.612	0.010^*	2.12	1.20 ~ 3.75
hsCRP(Q1)			3.079	0.380
hsCRP = 1	0.264	0.252	1.093	0.296	1.30	0.79 ~ 2.13
hsCRP = 2	0.444	0.258	2.950	0.086	1.56	0.94 ~ 2.59
hsCRP = 3	0.299	0.258	1.340	0.247	1.35	0.81 ~ 2.24
TC	0.334	0.276	1.461	0.227	1.40	0.81 ~ 2.40
TG	−0.195	0.193	1.023	0.312	0.82	0.56 ~ 1.20
LDL-C	0.458	0.278	2.715	0.099	1.58	0.92 ~ 2.72
HDL-C	−0.391	0.268	2.123	0.145	0.68	0.40 ~ 1.14
Hcy	0.700	0.292	5.746	0.017^*	2.01	1.14 ~ 3.57
MTHFR C677T
CC			51.512	< 0.001^*
CT	1.401	0.198	50.270	< 0.001^*	4.06	2.76 ~ 5.98
TT	1.143	0.304	14.165	< 0.001^*	3.14	1.73 ~ 5.69

BMI body mass index, TG triglycerides, TC total cholesterol, LDL-C low density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, hsCRP high-sensitivity C-reative protein, Hcy: Homocysteine; Hypertension: normal = 0, Hypertension = 1; Hcy: <15 mmol/L = 0, ≥15 mmol/L = 1; TC:<5.18 mmol/L = 0, ≥5.18 mmol/L = 1;TG: <1.70 mmol/L = 0,≥1.70 mmol/L = 1;LDL-C: <3.37 mmol/L = 0, ≥3.37 mmol/L = 1; HDL-C: ≥1.04 mmol/L = 0,< 1.04 mmol/L = 1); HCY: <15 μmol / L = 0,≥ 15 μmol / L = 1; hsCRP (Quadripartite grouping):the first quartile = 0, the second quartile =1, the third quartile =2, the highest quartile =3; Gender: Female = 0,Male = 1; Smoking:No =0, yes = 1.Drinking: No = 0, Yes = 1
^*P<0.05 was considered to be statistically significant

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