Association of methylenetetrahydrofolate reductase (MTHFR) variant C677T and risk of carotid atherosclerosis: a cross-sectional analysis of 730 Chinese Han adults in Chongqing

Table 4 Allele and genotype frequencies of polymorphisms in MTHFR between CAS group and control group

	Allele/Genotype	CAS-group		Control group		OR (CI 95%)	P-value	P for HWE
		(n = 266)		(n = 464)
		n	%	n	%
ALL	C	281	52.8	669	72.1	1		0.74
	T	251	47.2	259	27.9	2.31(1.85,2.88)	P < 0.001^*
	C/C	58	21.8	249	53.7	1
	C/T	165	62	171	36.9	4.14 (2.90,5.92)	P < 0.001^*
	T/T	43	16.2	44	9.5	4.20(2.52,6.97)	P < 0.001^*
Women	C	82	52.6	231	84.9	1
	T	74	47.4	41	15.1	5.08(3.22,8.03)	P < 0.001^*
	CC	16	20.5	103	75.7	1
	CT	50	64.1	25	18.4	12.88(6.31,26.26)	P < 0.001^*
	TT	12	15.4	8	5.9	9.66(3.42,27.27)	P < 0.001^*
Men	C	199	52.9	438	66.8	1
	T	177	47.1	218	33.2	1.79(1.38,2.32)	P < 0.001^*
	CC	42	22.3	146	44.5	1
	CT	115	61.2	146	44.5	2.74(1.80,4.17)	P < 0.001^*
	TT	31	16.5	36	11	2.99(1.67,5.40)	P < 0.001^*

MTHFR Methylenetetrahydrofolate reductase, OR Odds ratio, CI Confidence interval, HWE Hardy-Weinberg equilibrium
^*P<0.05 was considered to be statistically significant

ISSN: 1471-2261