Fig. 5
From: β1 adrenoceptor antibodies induce myocardial apoptosis via inhibiting PGC-1α-related pathway
Overexpression of PGC-1α rescued the inhibitory effect of β1AA on VEGF expression. a Raw data of results of WB test. β1AA increased the protein expression of β1AR and caspase3, and inhibited the protein expression of VEGF. But the overexpression of PGC-1α inhibited the effect of β1AA. b Overexpression of PGC-1α increased the VEGF mRNA expression and rescued the inhibitory effect of β1AA. c ELISA test for secreted VEGF in the supernatant of the medium. Overexpression of PGC-1α also rescued the inhibitory effect of β1AA on the VEGF secretion. d and e overexpression of PGC-1α increased the NRF1 and ERRα mRNA expression and rescued the inhibitory effect of β1AA. **, P ≤ 0.01. Group data presented by mean ± SEM