Variable*†| All (n = 6333) | PCP-HF Q1 (n = 1583) | PCP-HF Q2 (n = 1583) | PCP-HF Q3 (n = 1584) | PCP-HF Q4 (n = 1583) | P-value for Trend |
---|---|---|---|---|---|---|
Sociodemographic & Lifestyle | ||||||
 Age, years, mean | 54.9 (0.3) | 44.9 (0.2) | 53.1 (0.3) | 62.4 (0.4) | 68.4 (0.4) | < 0.0001 |
 Female, % | 52.3 (0.7) | 62.6 (1.2) | 49.9 (1.6) | 48.8 (1.8) | 39.6 (1.8) | < 0.0001 |
 Black, % | 9.2 (0.6) | 5.8 (0.5) | 11.6 (0.8) | 11.9 (0.9) | 9.1 (1.0) | 0.08 |
 Current Smoking, % | 24.3 (1.0) | 18.0 (1.6) | 32.1 (2.0) | 23.9 (1.5) | 25.3 (2.0) | 0.19 |
 Living Environment, % |  |  |  |  |  | 0.15 |
  Urban | 46.1 (4.6) | 47.4 (5.1) | 47.2 (4.9) | 45.3 (4.4) | 42.9 (4.8) |  |
  Non-Urban | 53.9 (4.6) | 52.6 (5.1) | 52.8 (4.9) | 54.7 (4.4) | 57.1 (4.8) |  |
 Living Status, % |  |  |  |  |  | < 0.001 |
  Living Alone | 26.7 (0.9) | 23.3 (1.7) | 25.0 (1.9) | 29.7 (1.7) | 32.6 (1.7) |  |
  Living with Partner | 73.3 (0.9) | 76.7 (1.7) | 75.0 (1.9) | 70.3 (1.7) | 67.4 (1.7) |  |
 Educational Attainment, % |  |  |  |  |  | < 0.0001 |
  High-School Education or Below | 60.7 (1.6) | 47.1 (2.3) | 61.9 (2.2) | 71.1 (1.9) | 73.6 (2.0) |  |
  Post High-School Education | 39.3 (1.6) | 52.9 (2.3) | 38.1 (2.2) | 28.9 (1.9) | 26.4 (2.0) |  |
 Household Income Level, % |  |  |  |  |  | < 0.0001 |
  Below $25,000 | 40.8 (1.5) | 25.5 (1.7) | 37.5 (2.1) | 52.4 (2.0) | 62.6 (2.2) |  |
  $25,000–$50,000 | 32.1 (1.1) | 34.6 (2.0) | 35.2 (1.6) | 30.2 (1.9) | 24.5 (2.1) |  |
  Above $50,000 | 27.1 (1.6) | 39.9 (2.5) | 27.3 (2.0) | 17.4 (1.6) | 12.9 (1.8) |  |
Cardiovascular | ||||||
 10-Year HF Risk, median (min, max) | 1.6 (0.0, 82.7) | 0.3 (0.0, 0.8) | 1.5 (0.8, 2.7) | 4.2 (2.7, 6.7) | 10.8 (6.7, 82.7) | < 0.0001 |
 QRS Duration, milliseconds, mean | 98.3 (0.5) | 96.3 (0.6) | 97.5 (0.7) | 98.5 (0.6) | 103.2 (0.8) | < 0.0001 |
 Systolic Blood Pressure, mmHg, mean | 129.7 (0.4) | 118.7 (0.6) | 128.5 (0.6) | 136.8 (0.6) | 145.1 (0.8) | < 0.0001 |
 Previous Myocardial Infarction, % | 3.8 (0.3) | 0.8 (0.4) | 1.9 (0.5) | 5.5 (0.9) | 10.2 (1.0) | < 0.0001 |
 Antihypertensive Medication, % | 18.8 (0.7) | 2.3 (0.6) | 12.8 (1.1) | 24.9 (1.5) | 53.5 (1.8) | < 0.0001 |
Metabolic | ||||||
 Body Mass Index, kg/m2, mean | 27.4 (0.1) | 25.5 (0.1) | 28.0 (0.3) | 28.3 (0.2) | 29.2 (0.2) | < 0.0001 |
 Total Cholesterol, mg/dL, mean | 216.7 (0.9) | 206.5 (1.4) | 219.0 (1.5) | 226.5 (1.6) | 222.1 (1.2) | < 0.0001 |
 HDL Cholesterol, mg/dL, mean | 50.7 (0.5) | 53.7 (0.6) | 50.4 (0.7) | 50.0 (0.6) | 45.8 (0.7) | < 0.0001 |
 Fasting Blood Glucose, mg/dL, mean | 101.3 (0.8) | 91.5 (0.5) | 96.8 (1.0) | 101.6 (1.1) | 127.2 (2.2) | < 0.0001 |
 Glucose-Lowering Medication, % | 5.0 (0.3) | 0.2 (0.1) | 1.3 (0.3) | 4.8 (0.7) | 20.0 (1.8) | < 0.0001 |
Mortality | ||||||
 Cardiovascular Disease Mortality, % | 13.8 (0.6) | 2.2 (0.4) | 6.9 (0.8) | 23.4 (1.4) | 36.1 (1.5) | < 0.0001 |
 All-cause Mortality, % | 41.7 (1.3) | 11.3 (1.2) | 31.7 (1.7) | 65.5 (1.9) | 88.8 (1.1) | < 0.0001 |