Table 4 Performance of different models in terms of diagnostic accuracy at cutoff values with certain sensitivity and specificity levels

Sensitivity ≥ 95%

Low-risk

GRACE (IHDthMI) ≤81

868 (30%)*

0.951 (0.933,0.968)

0.967 (0.955,0.979)

0.365 (0.346,0.385)*

0.278 (0.258,0.298)

GRACE (IH6mDthMI) ≤79

821 (28%)*

0.951 (0.933,0.968)

0.965 (0.952,0.977)

0.345 (0.326,0.364)*

0.272 (0.252,0.291)

GRACE (IHDth) ≤79

520 (18%)*

0.951 (0.933,0.968)

0.944 (0.925,0.964)*

0.214 (0.197,0.231)*

0.237 (0.220,0.254)

GRACE (IH6mDth) ≤57

466 (16%)*

0.954 (0.937,0.971)

0.942 (0.921,0.963)*

0.191 (0.175,0.207)*

0.233 (0.216,0.249)

GRACE (OH6mDth) ≤66

408 (14%)*

0.956 (0.939,0.972)

0.936 (0.913,0.960)*

0.166 (0.151,0.182)*

0.228 (0.211,0.244)*

GRACE (OH6mDthMI) ≤68

438 (15%)*

0.956 (0.939,0.972)

0.941 (0.919,0.963)*

0.179 (0.164,0.195)*

0.230 (0.214,0.247)

HEART ≤3

639 (22%)

0.968 (0.954,0.982)

0.970 (0.957,0.983)

0.270 (0.252,0.288)

0.254 (0.236,0.272)

Specificity ≥ 95%

High-risk

GRACE (IHDthMI) > 186

357 (12%)*#

0.437 (0.397,0.477)* #

0.869 (0.856,0.882)* #

0.957 (0.949,0.965)

0.723 (0.676,0.769) #

GRACE (IH6mDthMI) > 161

328 (11%)*#

0.386 (0.347,0.426)* #

0.858 (0.845,0.872) #

0.956 (0.948,0.965)

0.695 (0.645,0.745) #

GRACE (IHDth) > 159

234 (8%)

0.234 (0.200,0.268)*

0.830 (0.815,0.844)

0.958 (0.950,0.966)

0.590 (0.527,0.653)*

GRACE (IH6mDth) > 133

218 (8%)*

0.203 (0.171,0.236)*

0.824 (0.809,0.838)*

0.957 (0.949,0.966)

0.550 (0.484,0.616)*

GRACE (OH6mDth) > 144

219 (8%)*

0.198 (0.166,0.230)*

0.823 (0.808,0.837)*

0.956 (0.947,0.964)

0.534 (0.468,0.600)*

GRACE (OH6mDthMI) > 151

189 (7%)*

0.154 (0.125,0.183)* #

0.815 (0.800,0.830)*

0.957 (0.949,0.966)

0.481 (0.410,0.553)*

HEART ≥8

272 (9%)#

0.325 (0.288,0.363) #

0.848 (0.834,0.862) #

0.965 (0.958,0.973) #

0.706 (0.652,0.760) #

TIMI ≥5

224 (8%)*

0.202 (0.169,0.234)*

0.823 (0.809,0.838)*

0.954 (0.946,0.963)*

0.531 (0.466,0.597)*