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Table 2 Sensitivity analyses

From: Assessing the risk of angiotensin receptor blockers on major cardiovascular events: a systematic review and meta-analysis of randomized controlled trials

 All-cause mortality  Myocardial infarction  Stroke  
RR (95%CI)I2NRR (95%CI)I2NRR (95%CI)I2N
Type of control
 Placebo0.99 (0.95–1.04)13180.96 (0.88–1.05)0140.91 (0.85–0.98)714
 Active1.01 (0.95–1.08)28211.03 (0.96–1.11)7230.93 (0.79–1.08)5422
 Active only ACE inhibitors1.04 (0.95–1.13)4681.01 (0.93–1.09)090.98 (0.88–1.10)08
Follow-up period
 ≤ 40 weeks1.01 (0.91–1.14)51190.98 (0.88–1.10)12180.94 (0.74–1.20)4018
 > 40 weeks1.00 (0.96–1.03)0201.03 (0.96–1.10)0190.90 (0.82–1.00)4518
Proportion of males
 ≤ 50%0.93 (0.86–1.00)061.02 (0.85–1.22)3750.76 (0.68–0.84)05
 > 50%1.02 (0.97–1.06)23331.01 (0.95–1.07)0320.96 (0.87–1.05)2831
Age
 ≤ 65 years0.98 (0.88–1.09)32180.95 (0.85–1.06)0151.03 (0.80–1.34)2212
 > 65 years1.01 (0.98–1.05)10201.04 (0.98–1.10)0210.92 (0.84–1.00)4123
BMI
 Normal range0.84 (0.60–1.19)3170.81 (0.41–1.57)061.21 (0.77–1.90)05
 Overweight and obese1.01 (0.98–1.04)0241.01 (0.96–1.07)5240.92 (0.83–1.01)4923
Elevated total cholesterol
 ≥ 200 mg/dL0.98 (0.91–1.05)15100.99 (0.91–1.08)080.82 (0.74–0.91)67
Elevated LDL
 ≥ 120 mg/dL1.01 (0.90–1.14)3670.97 (0.87–1.07)060.86 (0.70–1.07)455
Decreased HDL
 < 50 mg/dL1.01 (0.95–1.08)15110.99 (0.89–1.09)20100.90 (0.82–0.98)08
Elevated triglyceride
 ≥ 150 mg/dL1.01 (0.94–1.08)1380.99 (0.90–1.09)1680.92 (0.83–1.01)07
Proportion of smokers
 < 25%0.91 (0.84–0.98)2120.99 (0.88–1.11)0130.81 (0.67–0.99)4112
 ≥ 25%0.99 (0.95–1.05)7150.99 (0.91–1.01)0120.92 (0.87–0.98)012
Hypertension
 Only patients with hypertension0.98 (0.89–1.07)0121.02 (0.80–1.29)27120.82 (0.66–1.03)5713
Chronic heart failure (CHF)
 Only patients without CHF0.97 (0.92–1.03)0110.99 (0.83–1.18)43120.85 (0.73–1.00)4711
 Only patients with CHF1.00 (0.85–1.19)7561.06 (0.86–1.32)081.04 (0.81–1.32)148
Diabetes mellitus (DM)
 Only patients without DM0.99 (0.38–2.61)020.65 (0.26–1.59)4830.72 (0.50–1.04)373
 Only patients with DM1.04 (0.88–1.23)070.99 (0.53–1.80)6741.31 (0.73–2.35)303
Ischemic/coronary artery disease
 Only patients with ischemic/coronary artery disease1.06 (0.91–1.22)2570.97 (0.88–1.07)071.02 (0.84–1.24)05
Chronic kidney disease
 Only patients with chronic kidney disease0.86 (0.66–1.12)5080.99 (0.71–1.41)2091.08 (0.83–1.39)08
  1. CI confidence interval; N number of studies; RR relative risk; ACE angiotensin-converting-enzyme
  2. Statistically significant results are emboldened