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Table 2 High throughput multiplex analysis of biomarkers selected by supervised multivariate principal component analysis. Plasma concentrations of the assessed proteins are expressed on a log2-scale. Inter-group differences were assessed using analysis of variance method. *Bonferroni-corrected significant values (p < 0.0022)

From: Proteomic analysis reveals sex-specific biomarker signature in postural orthostatic tachycardia syndrome

Biomarker

POTS+

(n = 113)

POTS-

(n = 283)

P-value*

TIM

4.32 (0.08)

4.49 (0.05)

0.078

PSGL1

0.69 (0.04)

0.8 (0.02)

0.009

CTSL1

5.3 (0.04)

5.46 (0.03)

0.004

MB

4.86 (0.07)

5.14 (0.06)

0.0020*

VEGFD

6.7 (0.06)

6.82 (0.03)

0.062

PlGF

7.1 (0.05)

7.21 (0.04)

0.131

MMP1

3.04 (0.14)

3.41 (0.09)

0.029

GDF15

8.22 (0.07)

8.42 (0.05)

0.058

FAS

6.93 (0.04)

7.02 (0.03)

0.045

TF

5.53 (0.04)

5.61 (0.03)

0.120

AM

5.83 (0.09)

6.05 (0.05)

0.029

UPAR

9.66 (0.03)

9.72 (0.03)

0.127

TNFR2

4.82 (0.04)

4.9 (0.03)

0.116

TRAIL

8.44 (0.04)

8.52 (0.03)

0.183

MCP1

3.07 (0.05)

3.24 (0.05)

0.014

TRAILR2

1.21 (0.03)

1.28 (0.02)

0.080

OPG

9.16 (0.04)

9.25 (0.03)

0.095

CASP8

1.45 (0.07)

1.33 (0.05)

0.126

HGF

6.22 (0.04)

6.34 (0.04)

0.030

CD40L

8.57 (0.11)

8.6 (0.07)

0.647

GH

9.37 (0.26)

8.37 (0.2)

0.0019*

PTX3

1.38 (0.06)

1.28 (0.04)

0.124

SRC

7.66 (0.07)

7.77 (0.03)

0.087