Table 3 Genotype frequency of candidate genes (АСЕ, AGT, AGTR1, ADRB1, ADRA2B) in the indigenous population and non-indigenous population of Mountain Shoria with various pathophysiological forms of AH
Genotype | Indigenous population | Non-indigenous population | ||||
|---|---|---|---|---|---|---|
V-D AH | R-D AH | р | V-D AH | R-D AH | р | |
Gene АСЕ, rs4340 | ||||||
I/I | 44.4 | 42.3 | 0.719 | 22.2 | 29.6 | 0.534 |
I/D | 51.8 | 36.6 | 0.130 | 44.4 | 53.7 | 0.829 |
D/D | 3.8 | 21.1 | 0.035 | 33.3 | 16.7 | 0.321 |
Gene AGT, rs699 | ||||||
T/T | 46.9 | 20.0 | 0.046 | 45.4 | 47.0 | 0.812 |
T/C | 31.2 | 40.0 | 0.480 | 27.3 | 17.7 | 0.283 |
C/C | 21.9 | 40.0 | 0.177 | 27.3 | 35.3 | 0.529 |
Gene AGTR1, rs5186 | ||||||
A/A | 65.6 | 55.6 | 0.426 | 35.7 | 19.2 | 0.229 |
A/C | 28.1 | 18.5 | 0.261 | 42.9 | 23.1 | 0.112 |
C/C | 6.3 | 25.9 | 0.041 | 21.4 | 57.7 | 0.029 |
Gene ADRB1, rs1801252 | ||||||
A/A | 59.2 | 63.0 | 0.621 | 50.0 | 72.9 | 0.108 |
A/G | 33.8 | 25.9 | 0.371 | 50.0 | 22.9 | 0.059 |
G/G | 7.0 | 11.1 | 0.520 | 0.0 | 4.2 | 0.582 |
Gene ADRA2B, rs28365031 | ||||||
I/I | 23.9 | 50.0 | 0.115 | 29.6 | 50.0 | 0.104 |
I/D | 53.5 | 31.3 | 0.163 | 37.0 | 31.3 | 0.886 |
D/D | 22.6 | 18.7 | 0.287 | 33.4 | 18.7 | 0.098 |