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Table 4 Multivariable analysis of HRnV and HRnVm parameters by adjusting for age and sex

From: Heart rate n-variability (HRnV) and its application to risk stratification of chest pain patients in the emergency department

 

HRV

HR2V

HR3V

OR (95% CI)

p

OR (95% CI)

p

OR (95% CI)

p

Mean NN

0.999 (0.998–1)

0.005*

0.999 (0.999–1.000)

0.005*

1.000 (0.999–1.000)

0.005*

SDNN

0.993 (0.986–0.999)

0.035*

0.996 (0.992–1.000)

0.040*

0.998 (0.995–1.000)

0.093

RMSSD

0.990 (0.982–0.998)

0.011*

0.992 (0.985–0.999)

0.016*

0.994 (0.988–1.000)

0.047*

Skewness

1.064 (0.995–1.138)

0.068

1.082 (0.983–1.191)

0.109

1.140 (1.005–1.293)

0.042*

Kurtosis

1.005 (1.000–1.011)

0.047*

1.008 (0.997–1.019)

0.139

1.011 (0.993–1.030)

0.238

Triangular index

0.967 (0.93–1.006)

0.093

0.971 (0.940–1.002)

0.070

0.982 (0.953–1.013)

0.256

NN50

0.993 (0.988–0.999)

0.013*

0.991 (0.982–0.999)

0.030*

0.990 (0.979–1.001)

0.078

pNN50

0.979 (0.963–0.996)

0.015*

0.986 (0.972–0.999)

0.033*

0.989 (0.977–1.001)

0.063

NN50n

–

–

0.983 (0.964–1.002)

0.081

0.954 (0.906–1.005)

0.077

pNN50n

–

–

0.975 (0.947–1.004)

0.086

0.952 (0.903–1.004)

0.069

Total power

1.000 (1.000–1.000)

0.042*

1.000 (1.000–1.000)

0.026*

1.000 (1.000–1.000)

0.104

VLF power

1.000 (1.000–1.000)

0.167

1.000 (1.000–1.000)

0.082

1.000 (1.000–1.000)

0.152

LF power

1.000 (1.000–1.000)

0.093

1.000 (1.000–1.000)

0.033*

1.000 (1.000–1.000)

0.105

HF power

1.000 (0.999–1.000)

0.003*

1.000 (1.000–1.000)

0.016*

1.000 (1.000–1.000)

0.101

LF power norm

1.002 (0.994–1.011)

0.589

0.999 (0.990–1.007)

0.769

0.994 (0.984–1.003)

0.202

HF power norm

0.998 (0.989–1.006)

0.589

1.001 (0.993–1.010)

0.769

1.006 (0.997–1.016)

0.202

LF/HF

1.039 (0.961–1.124)

0.336

1.013 (0.962–1.066)

0.620

0.999 (0.970–1.028)

0.928

Poincaré SD1

0.986 (0.975–0.997)

0.011*

0.989 (0.980–0.998)

0.016*

0.992 (0.983–1.000)

0.047*

Poincaré SD2

0.995 (0.990–1.000)

0.050*

0.997 (0.994–1.000)

0.046*

0.998 (0.996–1.000)

0.098

SampEn

0.852 (0.630–1.152)

0.297

0.752 (0.559–1.010)

0.058

1.000 (1.000–1.000)

0.956

ApEn

1.669 (0.754–3.693)

0.207

2.668 (1.139–6.246)

0.024*

1.507 (0.555–4.096)

0.421

DFA, α1

0.991 (0.593–1.654)

0.971

1.072 (0.622–1.848)

0.802

0.962 (0.550–1.682)

0.891

DFA, α2

1.499 (0.750–2.993)

0.252

1.204 (0.782–1.853)

0.400

1.193 (0.941–1.512)

0.146

 

HR2V1

HR3V1

HR3V2

OR (95% CI)

p

OR (95% CI)

p

OR (95% CI)

p

Mean NN

0.999 (0.999–1.000)

0.005*

1.000 (0.999–1.000)

0.005*

1.000 (0.999–1.000)

0.005*

SDNN

0.996 (0.993–1.000)

0.052

0.998 (0.995–1.000)

0.064

0.997 (0.995–1.000)

0.049*

RMSSD

0.992 (0.985–0.998)

0.015*

0.993 (0.986–0.999)

0.023*

0.993 (0.987–0.999)

0.023*

Skewness

1.066 (0.984–1.156)

0.118

1.079 (0.983–1.185)

0.108

1.099 (0.982–1.229)

0.099

Kurtosis

1.007 (0.999–1.015)

0.096

1.005 (0.994–1.017)

0.377

1.010 (0.994–1.025)

0.218

Triangular index

0.985 (0.960–1.010)

0.234

0.985 (0.965–1.005)

0.137

0.977 (0.951–1.003)

0.088

NN50

0.996 (0.991–1.000)

0.047*

0.997 (0.993–1.001)

0.130

0.993 (0.986–1.001)

0.084

pNN50

0.986 (0.973–1.000)

0.046*

0.990 (0.979–1.002)

0.111

0.989 (0.978–1.001)

0.076

NN50n

0.990 (0.980–1.000)

0.059*

0.982 (0.963–1.001)

0.064

0.975 (0.943–1.008)

0.142

pNN50n

0.971 (0.941–1.002)

0.063

0.947 (0.893–1.004)

0.067

0.962 (0.915–1.012)

0.131

Total power

1.000 (1.000–1.000)

0.064

1.000 (1.000–1.000)

0.096

1.000 (1.000–1.000)

0.035*

VLF power

1.000 (1.000–1.000)

0.173

1.000 (1.000–1.000)

0.180

1.000 (1.000–1.000)

0.086

LF power

1.000 (1.000–1.000)

0.100

1.000 (1.000–1.000)

0.108

1.000 (1.000–1.000)

0.037*

HF power

1.000 (1.000–1.000)

0.006*

1.000 (1.000–1.000)

0.014*

1.000 (1.000–1.000)

0.025*

LF power norm

1.000 (0.991–1.009)

0.960

0.995 (0.984–1.005)

0.324

0.995 (0.985–1.005)

0.329

HF power norm

1.000 (0.991–1.009)

0.960

1.005 (0.995–1.016)

0.324

1.005 (0.995–1.015)

0.329

LF/HF

1.023 (0.968–1.081)

0.428

0.999 (0.969–1.030)

0.940

0.996 (0.967–1.026)

0.786

Poincaré SD1

0.988 (0.979–0.998)

0.015*

0.990 (0.981–0.999)

0.023*

0.990 (0.981–0.999)

0.023*

Poincaré SD2

0.997 (0.995–1.000)

0.059

0.998 (0.997–1.000)

0.068

0.998 (0.996–1.000)

0.052

SampEn

0.870 (0.632–1.197)

0.393

0.842 (0.578–1.227)

0.371

0.716 (0.504–1.019)

0.064

ApEn

2.520 (1.009–6.298)

0.048*

1.413 (0.575–3.471)

0.451

3.461 (1.201–9.971)

0.021*

DFA, α1

0.898 (0.508–1.587)

0.710

1.068 (0.555–2.058)

0.843

1.005 (0.543–1.838)

0.988

DFA, α2

1.507 (0.751–3.025)

0.249

1.500 (0.746–3.014)

0.255

1.172 (0.764–1.798)

0.467

  1. HRV Heart rate variability, OR Odds ratio, CI Confidence interval, mean NN average of R-R intervals, SDNN Standard deviation of R-R intervals, RMSSD Square root of the mean squared differences between R-R intervals, NN50, the number of times that the absolute difference between 2 successive R-R intervals exceeds 50 ms; pNN50, NN50 divided by the total number of R-R intervals; NN50n, the number of times that the absolute difference between 2 successive RRnI/RRnIm sequences exceeds 50 × n ms; pNN50n, NN50n divided by the total number of RRnI/RRnIm sequences; VLF Very low frequency, LF Low frequency, HF High frequency, SD Standard deviation, SampEn Sample entropy, ApEn Approximate entropy, DFA Detrended fluctuation analysis
  2. * p < 0.05
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BMC Cardiovascular Disorders

ISSN: 1471-2261

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