Circulating metabolite profiles to predict response to cardiac resynchronization therapy

Table 2 Differential metabolites for discrimination before CRT in Responders and Non-responders

Metabolite	VIP^a	P-value^b	AUC^c	Sensitivity (%)	Specificity (%)
Valine	5.32	8.2E-03	0.70	0.67	0.75
Citric acid	1.07	2.7E-02	0.68	0.78	0.50
Hypoxanthine	2.34	1.1E-02	0.71	0.63	0.75
Isoleucine	15.39	9.1E-06	0.83	0.67	0.83
Inosine	1.03	1.1E-02	0.69	0.63	0.70
Phenylalanine	10.32	1.1E-04	0.79	0.70	0.79
Indoleacetic acid	1.04	2.3E-03	0.75	0.81	0.71
Tryptophan	7.19	2.5E-06	0.84	0.77	0.79
Hexanoylcarnitine	1.01	3.5E-03	0.74	0.63	0.79
Sphingosine 1-phosphate	1.09	3.3E-04	0.77	0.70	0.77
Tetradecenoylcarnitine	0.85	7.4E-04	0.75	0.66	0.75
LysoPC(14:0)	1.59	6.8E-04	0.76	0.62	0.77
Linoleyl carnitine	2.02	4.0E-04	0.76	0.77	0.70
LysoPC(20:3)	3.47	3.8E-03	0.75	0.85	0.62
LysoPC(22:6)	1.31	4.7E-04	0.76	0.77	0.62
Oleoylcarnitine	2.28	6.4E-04	0.78	0.66	0.79
Linoleic acid	1.07	1.8E-03	0.76	0.70	0.75

^a Variable importance in the projection (VIP) was obtained from the OPLS-DA model. ^bP-value was calculated from the Student’s t-test. ^c Area under the receiver operating characteristic (ROC) curve

ISSN: 1471-2261