Outcome | No.of SRs | No.of original studies | No.of cases/ controls | Follow-up range (weeks) | Estimate (95%CI) | P- value | 95%PI | I2(P*) | Egger’s P value |
---|---|---|---|---|---|---|---|---|---|
BP response rate | |||||||||
 aliskiren 75 mg vs placebo | 2 | 2 | 292/291 | 8 | 1.41 [1.03–1.94] | 0.03 | NA | 62%(0.11) | NA |
 aliskiren150mg vs placebo | 2 | 3 | 460/451 | 8 | 1.42 [1.16–1.75] | 0.001 | [0.19–10.87] | 43%(0.17) | 0.008 |
 aliskiren300mg vs placebo | 2 | 7 | 1443/1480 | 8 | 1.65 [1.46–1.85] | < 0.001 | [1.17–2.35] | 49%(0.07) | 0.167 |
 aliskiren vs ARBs (low dose) | 2 | 2 | 479/361 | 4–8 | 0.92 [0.81–1.04] | 0.16 | NA | 0%(0.89) | NA |
 aliskiren vs ARBs (low to high dose) | 2 | 2 | 543/570 | 8–12 | 0.99 [0.90–1.09] | 0.88 | NA | 0%(0.51) | NA |
 aliskiren vs ARBs (high dose) | 1 | 1 | 175/60 | 8 | 1.07 [0.86–1.33] | 0.52 | NA | NA | NA |
 aliskiren vs ACEIs | 1 | 1 | 414/418 | 8–26 | 1.10 [0.99–1.24] | 0.09 | NA | NA | NA |
 aliskiren vs amlodipine | 1 | 2 | 513/492 | 8–32 | 0.77[0.69–0.85] | < 0.00001 | NA | 0% (0.37) | NA |
 aliskiren vs HCTZ | 1 | 1 | 180/173 | 8 | 1.08 [0.92–1.28] | 0.34 | NA | NA | NA |
 aliskiren vs atenolol | 1 | 1 | 230/230 | 12 | 0.84[0.74–0.95] | 0.007 | NA | NA | NA |
BP control rate | |||||||||
 aliskiren 75 mg vs placebo | 2 | 1 | 177/176 | 8 | 1.30 [0.95–1.77] | 0.1 | NA | NA | NA |
 aliskiren150mg vs placebo | 2 | 3 | 475/666 | 8 | 1.51 [1.06–2.16] | 0.02 | [0.03–76.62] | 62%(0.07) | 0.084 |
 aliskiren300mg vs placebo | 2 | 6 | 1276/1288 | 8 | 1.62 [1.10–2.38] | 0.01 | [0.41–6.36] | 90% (< 0.00001) | 0.741 |
 aliskiren vs ARBs (low to high dose) | 2 | 5 | 919/921 | 8–12 | 1.05 [0.89–1.23] | 0.57 | [0.68–1.62] | 37%(0.18) | 0.357 |
 aliskiren vs ARBs (high dose) | 1 | 1 | 175/60 | 8 | 1.01 [0.72–1.43] | 0.93 | NA | NA | NA |
 aliskiren vs ACEIs | 1 | 1 | 414/418 | 8–26 | 1.12 [0.96–1.30] | 0.15 | NA | NA | NA |
 aliskiren vs amlodipine | 1 | 1 | 201/179 | 8 | 0.72 [0.57–0.91] | 0.006 | NA | NA | NA |
 aliskiren vs HCTZ | 1 | 1 | 180/173 | 8 | 1.24 [0.97–1.59] | 0.09 | NA | NA | NA |
 aliskiren vs atenolol | 1 | 1 | 230/230 | 12 | 0.86 [0.68–1.08] | 0.18 | NA | NA | NA |